Results 141 to 150 of about 182,666 (399)

Exploration of a potent PI3 kinase/mTOR inhibitor as a novel anti-fibrotic agent in IPF [PDF]

, 2016
© 2016 BMJ Publishing Group Ltd & British Thoracic Society.Rationale Idiopathic pulmonary fibrosis (IPF) is the most rapidly progressive and fatal of all fibrotic conditions with no curative therapies.
Blanchard, AD, Chambers, RC, Durrenberger, PF, Eley, JD, Franklin, L, Genovese, F, Lukey, PT, Maher, TM, Man, Y, Marshall, RP, McAnulty, RJ, Mercer, PF, Nanthakumar, CB, Nicholson, AG, Plate, M, Sulikowski, MG, Woodcock, HV, Yang, S   +17 more
core   +2 more sources

Fibroblast Senescence in Idiopathic Pulmonary Fibrosis

Frontiers in Cell and Developmental Biology, 2020
Aging is an inevitable and complex natural phenomenon due to the increase in age. Cellular senescence means a non-proliferative but viable cellular physiological state. It is the basis of aging, and it exists in the body at any time point.
Yifan Lin, Zhi-hao Xu
semanticscholar   +1 more source

Associations of Fire Smoke and Other Pollutants With Incident Rheumatoid Arthritis and Rheumatoid Arthritis–Associated Interstitial Lung Disease

Arthritis &Rheumatology, EarlyView.
Objective The aim of this study was to determine whether pollutants such as fire smoke–related particulate matter <2.5 μm (PM2.5) are associated with incident rheumatoid arthritis (RA) and RA‐associated interstitial lung disease (RA‐ILD). Methods This patient–control study used Veterans Affairs (VA) data from October 1, 2009, to December 31, 2018.
Vanessa L. Kronzer, Yangyuna Yang, Punyasha Roul, James L. Crooks, Cynthia S. Crowson, John M. Davis III, Jeffrey A. Sparks, Jeffrey R. Pierce, Katelyn O'Dell, Brian C. Sauer, Grant W. Cannon, Joshua F. Baker, Ted R. Mikuls, Bryant R. England   +13 more
wiley   +1 more source

CONAN: Complementary Pattern Augmentation for Rare Disease Detection [PDF]

arXiv, 2019
Rare diseases affect hundreds of millions of people worldwide but are hard to detect since they have extremely low prevalence rates (varying from 1/1,000 to 1/200,000 patients) and are massively underdiagnosed. How do we reliably detect rare diseases with such low prevalence rates?
arxiv  

Recent advances in interstitial lung disease research [PDF]

, 2006
The interstitial lung diseases are a diverse collection of disorders characterized by impaired gas exchange, restricted physiology on lung function testing, and diffuse parenchymal lung infiltrates on radiography.
Vassallo, Robert
core  

The role of nailfold capillaroscopy in interstitial lung diseases - Can it differentiate idiopathic cases from collagen tissue disease associated interstitial lung diseases? [PDF]

, 2015
Introduction: Nailfold capillaroscopy (NFC) is a non-invasive diagnostic test that is mostly used for early diagnosis of collagen tissue diseases (CTDs). We aimed to evaluate whether NFC findings could be a clue for discriminating idiopathic interstitial
Altınışık, Göksel, Balkarli, A., Çakmakçi Karadoğan, D., Çobankara, Veli, Önal, Özgür   +4 more
core   +1 more source

Peripheral Biomarker Signatures in Rheumatoid Arthritis‐Associated Interstitial Lung Disease

Arthritis &Rheumatology, Accepted Article.
Objective Rheumatoid arthritis‐associated interstitial lung disease (RA‐ILD) is a significant cause of morbidity and mortality among patients with RA, yet effective risk stratification for RA‐ILD is lacking. We sought to characterize unique peripheral blood biomarker signatures in RA that could improve RA‐ILD discrimination beyond clinical and genetic ...
Austin M. Wheeler, Joshua F. Baker, Thomas R. Riley IV, Tate M. Johnson, Yangyuna Yang, Punyasha Roul, Katherine D. Wysham, Grant W. Cannon, Gary Kunkel, Gail Kerr, Dana P. Ascherman, Paul Monach, Andreas Reimold, Scott Matson, Jill A. Poole, Michael J. Duryee, Geoffrey M. Thiele, Ted R. Mikuls, Bryant R. England   +18 more
wiley   +1 more source

Features of transbronchial lung cryobiopsy‐diagnosed fibrotic hypersensitivity pneumonitis

The Clinical Respiratory Journal, Volume 17, Issue 1, Page 50-58, January 2023., 2023
This study describes the clinical and pathological features of fibrotic hypersensitivity pneumonitis diagnosed with transbronchial lung crybiopsy. Usual interstitial pneumonia was the most frequent pathological finding of fibrotic hypersensitivity pneumonitis.
Xi Zhan, Yingzhen Du, Jiang Luo, Yifan Que, Chao Hu, Lili Xu, Zhen Wang, Yanbing Wu, Mulan Jin, Chunming Zheng, Yanhong Gao, Christopher Chang, Hongxia Li, Zhaohui Tong, Guogang Xu   +14 more
wiley   +1 more source

Thoracic high resolution CT using the modified VetMousetrap (TM) device is a feasible method for diagnosing canine idiopathic pulmonary fibrosis in awake West Highland White Terriers [PDF]

, 2019
Canine idiopathic pulmonary fibrosis is a chronic, progressive interstitial lung disease particularly prevalent in West Highland White Terriers. In the present prospective pilot study, we evaluated the feasibility of modified VetMousetrap (TM) device in ...
Holopainen, Saila, Lappalainen, Anu K., Lilja-Maula, Liisa, Lohi, Hannes, Rajamaki, Minna M., Rautala, Elina   +5 more
core   +1 more source

Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis

Science Translational Medicine, 2019
Interleukin-11 is important for lung fibroblast activation in idiopathic pulmonary fibrosis, and its signaling represents a therapeutic target. Targeting IL-11 in lung fibrosis In idiopathic pulmonary fibrosis (IPF), chronic activation of invasive ...
B. Ng, Jinrui Dong, Giuseppe D’Agostino, S. Viswanathan, A. Widjaja, Wei-Wen Lim, Nicole S. J. Ko, J. Tan, S. Chothani, Benjamin Huang, Chen Xie, C. Pua, A. Chacko, Nuno Guimarães-Camboa, S. Evans, A. Byrne, T. Maher, Jiurong Liang, D. Jiang, P. Noble, S. Schafer, S. Cook   +21 more
semanticscholar   +1 more source