Results 171 to 180 of about 106,594 (302)

ITGA5 as a Dual Regulator of Epithelial‐Mesenchymal Transition and Epithelial Cell Anoikis Resistance: Functional Validation and Drug Prediction

Cell Proliferation, EarlyView.
Proteomics and functional validation reveal ITGA5 as a dual promoter of epithelial‐mesenchymal transition and anoikis resistance in human bronchial epithelium: targeting ITGA5 represents a novel therapeutic strategy for asthma airway remodelling. ABSTRACT Airway remodelling is a major contributor to persistent airflow limitation and irreversible lung ...
Ting Wang, Ling Rao, Xiaofang Li, Miaofen Zhang, Huiting Huang, Zhiyan Luo, Gang Liao, Yong Jiang, Shaofeng Zhan, Qiong Liu, Xiufang Huang   +10 more
wiley   +1 more source

An update on the landscape of collagen bioactive fragments

The FEBS Journal, EarlyView.
The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley   +1 more source

Towards causal validation and clinical translation of the PAK2-fibroblast axis in idiopathic pulmonary fibrosis. [PDF]

Eur Respir J
Sun M, Zang D, Chen J.
europepmc   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

Identification of a conserved sequence of disease progression in Idiopathic Pulmonary Fibrosis. [PDF]

Am J Respir Crit Care Med
Huang X, Wu P, Guttentag AR, Quintana M, Kropski JA, Blackwell TS, Salisbury ML.   +6 more
europepmc   +1 more source

PDE4 Inhibition in Dermatologic Disease: Impacts Beyond Inflammation

International Journal of Dermatology, EarlyView.
This graphical abstract demonstrates the comprehensive mechanism of PDE4 inhibition in skin physiology. By increasing intracellular cAMP and activating PKA, PDE4 inhibitors exert pleiotropic effects, including immune modulation, pigmentation regulation, barrier enhancement, sensory neuron modulation, and improved wound healing with reduced fibrosis ...
Keana Khodadad, Nicole E. Chin, Raj Chovatiya   +2 more
wiley   +1 more source

Combined HDL-BMI Phenotyping Provides Incremental Prognostic Value in Idiopathic Pulmonary Fibrosis. [PDF]

J Clin Med
Shen Q, Ouyang X, Tan Y, Zhang Q, Hu F, He S, Peng H.   +6 more
europepmc   +1 more source

Implications of race‐neutral equations on interpretation of lung function in Australia

Internal Medicine Journal, EarlyView.
Abstract Background and Objective In 2022, the American Thoracic and European Respiratory Societies recommended a shift to race‐neutral equations for reporting and interpreting lung function tests. The impact of this change in the Australian population has not been comprehensively evaluated.
Helen Luo, Paul Finlay, Amanda Cestnik, Kanishka Nirmalan, Lauren Moncrieff, Garun S. Hamilton, Paul T King, Daniel J. Tan   +7 more
wiley   +1 more source

Epigenetic regulatory mechanisms and translational applications in idiopathic pulmonary fibrosis. [PDF]

Am J Clin Exp Immunol
Jiang M, Wang Q, Lyu Y, Hou X, Zhou X.
europepmc   +1 more source

Prevalence and Recovery of Arrhythmia‐Induced Cardiomyopathy in Patients With Newly Diagnosed Heart Failure Using a Wearable Defibrillator: A Real‐World Cohort Study

Journal of Cardiovascular Electrophysiology, EarlyView.
This graphical abstract summarizes the study design and main findings in patients with newly diagnosed left ventricular systolic dysfunction and concomitant arrhythmia undergoing early rhythm control under wearable cardioverter‐defibrillator protection.
Joerg Yogarajah, Jana Dannebaum, Ahmed Halim, Jamschid Sedighi, Matthias Mensch, Malte Kuniss, Thomas Neumann, Andreas Rieth, Julia Treiber, Samuel Sossalla, Andreas Hain   +10 more
wiley   +1 more source