Results 261 to 270 of about 195,645 (350)

Epstein–Barr virus and wild p53 in idiopathic pulmonary fibrosis

open access: bronze, 2001
She Lok   +4 more
openalex   +1 more source

Glutamine Metabolism: Molecular Regulation, Biological Functions, and Diseases

open access: yesMedComm, Volume 6, Issue 7, July 2025.
Tumor cells adapt to nutrient‐poor environments by altering metabolism to acquire essential nutrients. They convert glutamine into glutamate and α‐ketoglutarate, supporting mTOR activation and sugar biosynthesis. Disruption of mTORC1 signaling is linked to disease, while glutamine and leucine activation promotes cell growth and inhibits autophagy ...
Mudasir A. Kumar   +10 more
wiley   +1 more source

Autoimmune Diseases: Molecular Pathogenesis and Therapeutic Targets

open access: yesMedComm, Volume 6, Issue 7, July 2025.
This review provides a comprehensive overview of common autoimmune diseases, details clinical manifestations and summarizes the pathogenesis, including the breakdown of immune tolerance, initiation of autoimmune responses, and their progressive amplification.
Xiaoshuang Song   +9 more
wiley   +1 more source

Aberrant Wnt/β-Catenin Pathway Activation in Idiopathic Pulmonary Fibrosis [PDF]

open access: bronze, 2003
Marco Chilosi   +13 more
openalex   +1 more source

Outpatient Intravenous Dobutamine as Right Ventricular Support During Inhaled Prostacyclin Uptitration in Severe PH‐ILD

open access: yesPulmonary Circulation, Volume 15, Issue 3, July 2025.
ABSTRACT PH‐ILD carries a poor prognosis, particularly with PVR > 5 WU. The INCREASE trial demonstrated the successful use of inhaled treprostinil, but slow uptitration delays the effects. Our study suggests outpatient IV dobutamine as interim support, improving contractility and reducing PVR during uptitration.
A. Kumar   +4 more
wiley   +1 more source

Practical Considerations for Managing Patients on Tyvaso DPI (Treprostinil Inhalation Powder)

open access: yesPulmonary Circulation, Volume 15, Issue 3, July 2025.
ABSTRACT Pulmonary arterial hypertension (PAH) and pulmonary hypertension associated with interstitial lung disease (PH‐ILD) require a multifaceted, guideline‐directed management approach. This includes active patient participation in partnership with their healthcare team to minimize disease impact and improve survival.
Jennifer H. Keeley   +8 more
wiley   +1 more source

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