Results 21 to 30 of about 52,117 (235)

Risk factors for scoliosis progression in children with idiopathic short stature on growth hormone therapy. [PDF]

J Orthop Surg Res
Objective To analyze the clinical characteristics of scoliosis in children with idiopathic short stature after growth hormone treatment, and to explore the influence of growth hormone treatment on the progression of scoliosis and the risk factors for the
Zhang X, Ouyang H, Han X, Yao H, Zhou Y, Liu X.   +5 more
europepmc   +2 more sources

Efficacy and Safety of PEGylated Recombinant Human Growth Hormone in Children With Growth Hormone Deficiency and Idiopathic Short Stature: A Real-World Cohort Study. [PDF]

Int J Endocrinol
Background Growth hormone deficiency (GHD) and idiopathic short stature (ISS) are common causes of short stature in children. In China, PEGylated recombinant human GH (PEG‐rhGH, Jintrolong) has been approved for the treatment of both conditions. This study aimed to evaluate the efficacy and safety of PEG‐rhGH in children diagnosed with GHD or ISS and ...
Ge L, Zhao C, Yang Y, Xu L, Sun M, Su Y, Xu F, Huang Q, Tao N.   +8 more
europepmc   +2 more sources

Case analysis and literature review of 3 children with short stature with ACAN gene mutation [PDF]

Zhenduanxue lilun yu shijian, 2023
Objective: To analyze the clinical features and genetic changes of 3 children in short stature with ACAN gene mutation. Methods: The clinical data, laboratory examinations, and genetic testing results of 3 children with ACAN gene mutations diagnosed with
LI Yanxiao, LU Wenli, WANG Xinqiong, CHEN Ye, XIAO Yuan, DONG Zhiya, MA Xiaoyu
doaj   +1 more source

Prevalence and Aetiological Profile of Short Stature in School Children between 6-11 Years of Age- A Community Based Prospective Observational Study [PDF]

Journal of Clinical and Diagnostic Research, 2023
Introduction: Growth is a complex process and influenced by genetic back ground, different functions of endocrine system, nutrition, effect of any chronic disease and the level of individual physical activity.
Jasmine Kandagal, Suman Rath, Madhuri Maganti, Caroline Elizabeth George   +3 more
doaj   +1 more source

Involvement of the vitamin D receptor gene in the development of idiopathic short stature

Mìžnarodnij Endokrinologìčnij Žurnal, 2023
Background. The vitamin D receptor (VDR) gene is loca­lized in the chromosome 12 (region 12q13). Its polymorphic variants BsmI and FokI are the most promising in clinical and diagnostic terms.
O.V. Bolshova, M.O. Ryznychuk, D.A. Kvachenyuk   +2 more
doaj   +1 more source

SHOX Deletion and Idiopathic Short Stature: What Does the Clinician Need to Know? Case Series Report

Diagnostics, 2022
Children diagnosticated with idiopathic short stature (ISS) are probably, in most cases, underdiagnosticated. The genetic causes of ISS may be mutations of genes involved in local regulation of the growth plate or genes involved in the GH-IGF1 axis ...
Maria-Christina Ungureanu, Anamaria Hrisca, Lavinia Caba, Laura Teodoriu, Stefana Bilha, Cristina Preda, Letitia Leustean   +6 more
doaj   +1 more source

Serum Metabonomics Reveals Key Metabolites in Different Types of Childhood Short Stature

Frontiers in Pharmacology, 2022
Graphical AbstractSS, short stature; SDS, standard deviation scores; Control, normal height, n=30; ISS, idiopathic short stature n=31; GHD, short stature caused by growth hormone deficiency, n=29.
Guoyou Chen, Jinming Wang, Yisi Jing, Chunxiang Li, Wenyue Zhang, Shuang Yang, Ye Song, Xin Wang, Jincheng Liu, Dejun Yu, Zhichun Xu   +10 more
doaj   +1 more source

A new era of genetic diagnosis for short stature children: A review [PDF]

Precision and Future Medicine, 2022
Children with short stature are often presented to pediatric endocrinologists. Short stature is defined as the height that is more than two standard deviations below the corresponding mean height for a specific age and sex in a reference population ...
Yoo-Mi Kim
doaj   +1 more source

Plasma exosome miRNA-26b-3p derived from idiopathic short stature impairs longitudinal bone growth via the AKAP2/ERK1/2 axis

Journal of Nanobiotechnology, 2023
Background Currently, the etiology of idiopathic short stature (ISS) is still unclear. The poor understanding of the molecular mechanisms of ISS has largely restricted this strategy towards safe and effective clinical therapies.
Xijuan Liu, Jinghong Yuan, Zhiwen Wu, Junqiu Zhang, Yunfeng Shen, Jingyu Jia   +5 more
semanticscholar   +1 more source

A study of short stature among adolescents in the rural tertiary center- A prospective observational study [PDF]

Al Ameen Journal of Medical Sciences, 2021
Background: Long-term morbidities during the adolescence period cause short stature which is permanent, once epiphysis fuse. Objectives: To evaluate etiology in short stature adolescents and its relation with HSDS (Height Standard Deviation Score) and BA
Dixa Shah, Sunil Pathak, Prasad Muley, Prashant Modi, Naveed M Ahmed, Vivek Bhatt   +5 more
doaj