Results 1 to 10 of about 94,816 (308)

A Solution for Implementing Partnership Contracts on the Blockchain Platform Using the Decentralized Finance (DeFi) and the IDO Method [PDF]

open access: yesتحقیقات مالی اسلامی (پیوسته), 2023
Examining the challenges of usury-free banking is one of the most important issues that the country is facing. One of the main challenges of the country's banking system is the implementation of partnership contracts.
Mohammad Yaghoubi, Vahid Seyfi
doaj   +1 more source

A phase 1/2 trial of an immune-modulatory vaccine against IDO/PD-L1 in combination with nivolumab in metastatic melanoma

open access: yesNature Medicine, 2021
Anti-programmed death (PD)-1 (aPD1) therapy is an effective treatment for metastatic melanoma (MM); however, over 50% of patients progress due to resistance.
J. Kjeldsen   +16 more
semanticscholar   +1 more source

Prognostic factors and predictors of outcome in children with autism spectrum disorder: the role of the paediatrician

open access: yesItalian Journal of Pediatrics, 2021
Background Autism spectrum disorder is a complex condition with wide variation in type and severity that involves persistent challenges in social interaction, speech and nonverbal communication, restricted/repetitive behaviours and adaptive behaviours ...
Magda Di Renzo   +9 more
doaj   +1 more source

IDO/kynurenine pathway in cancer: possible therapeutic approaches

open access: yesJournal of Translational Medicine, 2022
Cancer is one of the leading causes of death in both men and women worldwide. One of the main changes associated with cancer progression, metastasis, recurrence, and chemoresistance is the change in the tumor immune microenvironment, especially ...
E. A. Abd El-Fattah
semanticscholar   +1 more source

Prognostic value of the PrPC-ILK-IDO1 axis in the mesenchymal colorectal cancer subtype

open access: yesOncoImmunology, 2021
The CMS4 mesenchymal subtype of colorectal cancer (CRC) is associated with poor prognosis and resistance to treatment. The cellular prion protein PrPC is overexpressed in CMS4 tumors and controls the expression of a panel of CMS4-specific genes in CRC ...
Alexandre Ghazi   +13 more
doaj   +1 more source

Perbandingan Efektivitas Cefazolin dan Ceftriaxone Sebagai Antibiotik Profilaksis Bedah Ortopedi Open Reduction Internal Fixation (ORIF) Fraktur Tertutup

open access: yesJPSCR: Journal of Pharmaceutical Science and Clinical Research, 2021
Infeksi daerah operasi (IDO) merupakan infeksi yang terjadi hingga 30 hari setelah operasi atau satu tahun setelah operasi pada pasien yang menerima implan dan mempengaruhi sayatan atau jaringan dalam di lokasi operasi.
Nurul Latifah   +2 more
doaj   +1 more source

Single Nucleotide Polymorphisms of Indoleamine 2,3-Dioxygenase 1 Influenced the Age Onset of Parkinson's Disease

open access: yesFrontiers in Bioscience-Landmark, 2022
Background: Earlier studies reported alterations of the kynurenine (KYN) pathway of tryptophan (TRP) metabolism in Parkinson’s disease (PD). The first rate-limiting enzymes indoleamine 2,3-dioxygenase (IDO) and tryptophan dioxygenase were observed ...
Nóra Török   +8 more
doaj   +1 more source

Tumor Cell IDO Enhances Immune Suppression and Decreases Survival Independent of Tryptophan Metabolism in Glioblastoma

open access: yesClinical Cancer Research, 2021
Purpose: Glioblastoma (GBM) is an incurable primary brain tumor that has not benefited from immunotherapy to date. More than 90% of GBM expresses the tryptophan (Trp) metabolic enzyme, indoleamine 2,3-dioxygenase 1 (IDO).
Lijie Zhai   +21 more
semanticscholar   +1 more source

Phase II trial of the IDO pathway inhibitor indoximod plus pembrolizumab for the treatment of patients with advanced melanoma

open access: yesJournal for ImmunoTherapy of Cancer, 2021
Background The indoleamine 2,3-dioxygenase (IDO) pathway is a key counter-regulatory mechanism that, in cancer, is exploited by tumors to evade antitumor immunity.
Y. Zakharia   +19 more
semanticscholar   +1 more source

Parental Attunement, Insightfulness, and Acceptance of Child Diagnosis in Parents of Children With Autism: Clinical Implications

open access: yesFrontiers in Psychology, 2020
Early parent–child relationships are an important factor influencing many domains of child development, even in the presence of autism. In this study, we investigated the associations between parent–child attunement during play, parental insightfulness ...
Magda Di Renzo   +6 more
doaj   +1 more source

Home - About - Disclaimer - Privacy