Results 91 to 100 of about 94,816 (308)

Indoleamine 2,3-dioxygenase (IDO) inhibitors and cancer immunotherapy

Cancer Treatment Reviews, 2022
Yuko Fujiwara, S. Kato, M. Nesline, J. Conroy, P. DePietro, S. Pabla, R. Kurzrock   +6 more
semanticscholar   +1 more source

Enhanced cancer therapy through synergetic photodynamic/immune checkpoint blockade mediated by a liposomal conjugate comprised of porphyrin and IDO inhibitor

Theranostics, 2019
Cancer metastases is still a hurdle for good prognosis and live quality of breast cancer patients. Treatment strategies that can inhibit metastatic cancer while treating primary cancer are needed to improve the therapeutic effect of breast cancer ...
Zeqian Huang, Gaofei Wei, Zishan Zeng, Yanjuan Huang, Liangfeng Huang, Yifeng Shen, Xiaoqi Sun, Congjun Xu, Chunshun Zhao   +8 more
semanticscholar   +1 more source

The outcomes of electronic personal health records in patients with heart failure or coronary artery disease

ESC Heart Failure, Volume 12, Issue 2, Page 1464-1468, April 2025.
Abstract Background There are limited data on the efficacy of smartphone‐based personal health records (PHRs) in patients with cardiovascular disease. This study aimed to examine the processes, outcomes and challenges associated with the implementation of integrated PHRs in patients with heart failure (HF) or coronary artery disease (CAD). Methods This
Kotaro Nochioka, Satoshi Yasuda, Takashi Shiroto, Saori Yamamoto, Haruka Sato, Yuhi Hasebe, Shigeo Godo, Makoto Nakano, Tomohiko Shindo, Kensuke Nishimiya, Kiyotaka Hao, Jun Takahashi, Keisuke Ido, Yoichi Kakuta, Hiroaki Shimizu, Hiroaki Shimokawa, Masaharu Nakayama   +16 more
wiley   +1 more source

Community perceptions, beliefs and factors determining family planning uptake among men and women in Ekiti State, Nigeria: finding from a descriptive exploratory study

BMJ Open
Objectives To examine family planning through the community’s perception, belief system and cultural impact; in addition to identifying the determining factors for family planning uptake.Design A descriptive exploratory study.Setting Three communities ...
Babatunde Adelekan, Oluwafunmilayo Oluwadamilola Ibikunle, Tope Michael Ipinnimo, Caroline Ajoke Bakare, Demilade Olusola Ibirongbe, Adebowale Femi Akinwumi, Austine Idowu Ibikunle, Emman Babatunde Ajidagba, Oluwafemi Oreoluwa Olowoselu, Opeyemi Oladipupo Abioye, Ayodele Kamal Alabi, Gilbert Ayodele Seluwa, Olasunkanmi Omotolani Alabi, Oyebanji Filani   +13 more
doaj   +1 more source

Quantitative Spatial Profiling of PD-1/PD-L1 Interaction and HLA-DR/IDO-1 Predicts Improved Outcomes of Anti–PD-1 Therapies in Metastatic Melanoma

Clinical Cancer Research, 2018
Purpose: PD-1/L1 axis–directed therapies produce clinical responses in a subset of patients; therefore, biomarkers of response are needed. We hypothesized that quantifying key immunosuppression mechanisms within the tumor microenvironment by ...
Douglas B. Johnson, J. Bordeaux, J. Kim, C. Vaupel, D. Rimm, T. Ho, R. Joseph, A. Daud, R. Conry, Elizabeth M. Gaughan, L. Hernandez-Aya, A. Dimou, P. Funchain, J. Smithy, J. Witte, Svetlana B. McKee, J. Ko, J. Wrangle, B. Dabbas, S. Tangri, J. Lameh, Jeff M. Hall, J. Markowitz, J. Balko, N. Dakappagari   +24 more
semanticscholar   +1 more source

Host–microbiota interaction drives 5‐hydroxyindole‐3‐acetic acid production to promote linear growth in infant mice

iMetaOmics, EarlyView.
This study discovered that Lactiplantibacillus plantarum Hi188 promoted linear growth in postweaning mice. Transcriptomic analysis, untargeted metabolomics, and in vitro experiments showed that the elevated levels of 5‐hydroxyindole‐3‐acetic acid (5‐HIAA) activated the hepatic aryl hydrocarbon receptor (AhR) and subsequently promoted insulin‐like ...
Yongmei Yang, Jing Yang, Weiyao Zhang, Linghao Zhou, Chenxu Zhu, Xuguang Zhang, Yuejian Mao, Meiling Zhang   +7 more
wiley   +1 more source

Weizmannia coagulans XY2 Mitigates Copper Neurotoxicity via Gut–Brain Axis Modulation of Tryptophan Metabolism and Oxidative‐Inflammatory Crosstalk

iMetaOmics, EarlyView.
Copper interferes with tryptophan metabolism and 5‐HT levels by modulating intestinal flora. Intestinal barrier breakdown and inflammatory response trigger nerve damage under copper exposure. W. coagulans XY2 alleviates copper‐induced neurotoxicity by targeting a multi‐dimensional “tryptophan metabolism‐antioxidant defense‐gut‐brain axis” network.
Yufang Gao, Xiaodong Zheng, Fujie Yan
wiley   +1 more source

Knowledge, attitude, and practice of healthcare professionals towards the prevention of Marjolin’s ulcer in an African suburban tertiary care institution: A cross-sectional study

Cancer Treatment and Research Communications
s: Background: This study aims to establish the level of knowledge, attitudes, and practices (KAP) of healthcare professionals towards Marjolin’s ulcers prevention.
Olakunle Fatai Babalola, Adedayo Idris Salawu, Adeniyi Steven Hassan, Innih Asuekome Kadiri, David Adekunle Onilede, Abiodun Idowu Okunlola, Kolawole Olubunmi Ogundipe   +6 more
doaj   +1 more source

IDO/TDO Inhibitor HTI-1090 [PDF]

, 2020
National Cancer Institute
openalex   +1 more source

Salmonella-Mediated Therapy Targeting Indoleamine 2, 3-Dioxygenase 1 (IDO) Activates Innate Immunity and Mitigates Colorectal Cancer Growth

Cancer Gene Therapy, 2019
Patients with colon cancer remain largely refractory to current immunotherapeutic strategies. This is, in part, due to the overexpression of the immune checkpoint protein indoleamine 2,3-dioxygenase 1 (IDO).
T. Phan, V. Nguyen, Marcela S. D’Alincourt, E. Manuel, Teodora I. Kaltcheva, Weimin Tsai, B. Blazar, D. Diamond, L. Melstrom   +8 more
semanticscholar   +1 more source