Results 161 to 170 of about 94,816 (308)
High PD-L1/IDO-2 and PD-L2/IDO-1 Co-Expression Levels Are Associated with Worse Overall Survival in Resected Non-Small Cell Lung Cancer Patients [PDF]
, 2021 Vienna Ludovini +16 more
openalex +1 more source
Timing of NAD Deficiency During Organogenesis Dictates Defect Type and Penetrance
The FASEB Journal, Volume 40, Issue 3, 15 February 2026.Pregnant mice on a vitamin B3‐free and tryptophan‐limited diet have embryos with Congenital NAD Deficiency Disorder, characterized by malformations and/or death. We longitudinally tracked the maternal NAD metabolome, embryo growth, and malformation occurrence. Mice with lower NAD Salvage Pathway metabolite levels and minimal levels of derived excretion
Kayleigh Bozon +6 more
wiley +1 more source
FEBS Open Bio, Volume 16, Issue 2, Page 432-446, February 2026.CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee +3 more
wiley +1 more source
VARIACIÓN ESPACIAL EN COMUNIDADES DE ESPONJAS DE LA COSTA ORIENTAL DE BAHÍA DE COCHINOS, CUBA
Revista Ciencias Marinas y Costeras, 2011 En octubre del 2002 se estudiaron las comunidades de esponjas en cuatro localidades del arrecife de la costa este de Bahía de Cochinos, Cuba. En cada localidad se establecieron sitios de muestreo de esponjas en las zonas ecológicas de cabezos coralinos ...
Hansel Caballero +3 more
doaj
Advanced Optical Materials, Volume 14, Issue 5, 2 February 2026.Nonlinear optical susceptibilities of five different materials that exhibit the ferroelectric nematic phase, as well as smectic A ferroelectric phase, are determined. The materials investigated include archetypal molecular architectures as well as mixtures showing room‐temperature ferroelectric phases.
Matija Lovšin +7 more
wiley +1 more source
Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.This review systematically deconstructs the pathological efferocytic—metabolic axis in tumours, framing it as a three‐stage, self‐reinforcing cycle: from metabolite‐driven macrophage recruitment, through hijacked surface recognition, to post‐phagocytic metabolic reprogramming that locks in immunosuppression.
Qianlu Yang, Jie Yan, Qianxi Yang
wiley +1 more source
IDO-ekspressio kielikarsinoomissa
, 2010 Kielikarsinooma on suusyövistä tavallisimpia. Kielen alueen syöpä voi lähettää jo aikaisessa vaiheessa etäpesäkkeitä, joten taudin diagnosointi on tehtävä huolellisesti. Indoleamiini-2,3-dioksygenaasi (IDO) on tryptofaanin aineenvaihduntaan osallistuva entsyymi, jolla on tutkimuksissa havaittu olevan immuunijärjestelmää muokkaava vaikutus.
openaire +1 more source
Elevating Circulating L‐Kynurenine Promotes Frailty in Aging Mice
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.ABSTRACT Background L‐Kynurenine (L‐Kyn), a product of tryptophan catabolism, increases with age and has been associated with reduced physical function and increased frailty in humans. Robustly expressed in skeletal muscle, kynurenine aminotransferases (KATs) degrade L‐Kyn into kynurenic acid and are regulated by the transcriptional co‐regulator ...
Mia Y. Kawaida +8 more
wiley +1 more source