Results 11 to 20 of about 94,816 (308)

IDO Vaccine Ablates Immune-Suppressive Myeloid Populations and Enhances Antitumor Effects Independent of Tumor Cell IDO Status

Cancer immunology research, 2022
An IDO-specific peptide vaccine is demonstrated to target IDO+ cells, enhancing vaccine-induced immune responses against non-IDO tumor antigens. These effects reduce tumor growth and inhibit immune-suppressive myeloid populations in multiple tumor models.
Rahul M. Nandre, Vivek Verma, Pankaj Gaur, V. Patil, Xingdong Yang, Zainab Ramlaoui, Nour Shobaki, M. Andersen, A. Pedersen, M. Zocca, M. Mkrtichyan, Seema Gupta, S. Khleif   +12 more
semanticscholar   +1 more source

Immunosuppressive IDO in Cancer: Mechanisms of Action, Animal Models, and Targeting Strategies

Frontiers in Immunology, 2020
Indoleamine 2, 3-dioxygenase 1 (IDO; IDO1; INDO) is a rate-limiting enzyme that metabolizes the essential amino acid, tryptophan, into downstream kynurenines. Canonically, the metabolic depletion of tryptophan and/or the accumulation of kynurenine is the
Lijie Zhai, A. Bell, Erik Ladomersky, Kristen L. Lauing, L. Bollu, J. Sosman, Bin Zhang, Jennifer D. Wu, S. Miller, J. Meeks, R. Lukas, Eugene J. Wyatt, L. Doglio, G. Schiltz, R. McCusker, D. Wainwright   +15 more
semanticscholar   +1 more source

IDO and Kynurenine Metabolites in Peripheral and CNS Disorders

Frontiers in Immunology, 2020
The importance of the kynurenine pathway in normal immune system function has led to an appreciation of its possible contribution to autoimmune disorders such as rheumatoid arthritis.
Yi-Shu Huang, J. Ogbechi, F. Clanchy, Richard O. Williams, T. Stone   +4 more
semanticscholar   +1 more source

Stromal-like Wilms tumor cells induce human Natural Killer cell degranulation and display immunomodulatory properties towards NK cells

OncoImmunology, 2021
The similarity of stromal-like Wilms tumor (str-WT) cells with mesenchymal stem cells (MSC), suggests their relevant role in the interplay with immune cells in the tumor microenvironment. We investigated the interaction between str-WT cells and NK cells.
Claudia Cantoni, Martina Serra, Erica Parisi, Bruno Azzarone, Angela Rita Sementa, Luigi Aurelio Nasto, Lorenzo Moretta, Giovanni Candiano, Cristina Bottino, Gian Marco Ghiggeri, Grazia Maria Spaggiari   +10 more
doaj   +1 more source

Comparative assessment of health-related quality of life among hypertensive patients attending state and federal government teaching hospitals in Ekiti State, Nigeria

Dialogues in Health, 2022
Background: Hypertension is a serious health problem and it is one of the diseases that impair health-related quality of life. The central tenet of care should be to improve health-related quality of life and overall well-being and not just be limited to
Tope Michael Ipinnimo, Kayode Rasaq Adewoye, Kabir Adekunle Durowade, Olusegun Elijah Elegbede, John Olujide Ojo, Bolade Folasade Dele-Ojo, Olarinde Jeffrey Oluwademilade, Oladele Ademola Atoyebi, Taofeek Adedayo Sanni, Olumide Temitope Asake, Blessing Waibi Daramola, Adetunji Olamide Fadipe   +11 more
doaj   +1 more source

IDO Expression in Cancer: Different Compartment, Different Functionality?

Frontiers in Immunology, 2020
Indoleamine 2,3-dioxygenase 1 (IDO1) is a cytosolic haem-containing enzyme involved in the degradation of tryptophan to kynurenine. Although initially thought to be solely implicated in the modulation of innate immune responses during infection ...
Annabel Meireson, M. Devos, L. Brochez
semanticscholar   +1 more source

Necrostatin-1 Prevents Ferroptosis in a RIPK1- and IDO-Independent Manner in Hepatocellular Carcinoma

Antioxidants, 2021
Ferroptosis is caused by the iron-mediated accumulation of lipid peroxidation, which is distinct from apoptosis and necroptosis. Necrostatin-1 inhibits receptor-interacting serine/threonine-protein kinase 1 (RIPK1) to initiate necroptosis; it also ...
H. Yuk, Mohamed M. Abdullah, Do-Hyung Kim, Haeseung Lee, Seung-Jin Lee   +4 more
semanticscholar   +1 more source

Chronic inflammation evoked by pathogenic stimulus during carcinogenesis

4 open, 2019
A pathogenic (biological or chemical) stimulus is the earliest information received by a cell that can result in the disruption of homeostasis with consequent development of disease.
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

Inflammatory cytokines-stimulated human muscle stem cells ameliorate ulcerative colitis via the IDO-TSG6 axis

Stem cell research & therapeutics, 2021
Background Muscle stem cells (MuSCs) are absolutely required for the formation, repair, and regeneration of skeletal muscle tissue. Increasing evidence demonstrated that tissue stem cells, especially mesenchymal stem cells (MSCs), can exert therapeutic ...
Shengchao Zhang, Jiankai Fang, Zhanhong Liu, Pengbo Hou, Lijuan Cao, Yuyan Zhang, Rui Liu, Yanan Li, Qianwen Shang, Yongjing Chen, Chao Feng, Guan Wang, G. Melino, Ying Wang, C. Shao, Yufang Shi   +15 more
semanticscholar   +1 more source

Epidemiology of anencephaly in a suburban Nigerian agrarian community in the rain forest: An 11-year retrospective study of a single hospital experience

Interdisciplinary Neurosurgery, 2020
Background: Anencephaly is a common but lethal form of neural tube defect which occurs as a result of failure of closure of the rostral neuropore. There is no data on this lethal congenital anomaly in our community.
Abiodun I. Okunlola, Olabisi T. Adeyemo, Augustine A. Adeniyi, Olakunle F. Babalola, Ayobami O. Oni, Richard A. Akinyoade, Cecilia K. Okunlola   +6 more
doaj   +1 more source