Results 271 to 280 of about 94,816 (308)
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Advances in Materials, 2021
Clinical trials confirm the combination of indoleamine 2,3‐dioxygenase (IDO) blockade and immunogenic chemotherapy represents a brilliant future in cancer therapy. However, it remains challenging to precisely activate chemo‐immunotherapy in situ to avoid
Yuan Ding +10 more
semanticscholar +1 more source
Clinical trials confirm the combination of indoleamine 2,3‐dioxygenase (IDO) blockade and immunogenic chemotherapy represents a brilliant future in cancer therapy. However, it remains challenging to precisely activate chemo‐immunotherapy in situ to avoid
Yuan Ding +10 more
semanticscholar +1 more source
IDO-triggered swellable polymeric micelles for IDO inhibition and targeted cancer immunotherapy
Journal of Controlled Release, 2023Indoleamine 2,3-dioxygenase (IDO) has been studied as a promising target for cancer immunotherapy. IDO catalyzes the oxidation of tryptophan into kynurenine, which subsequently activates regulatory T cells, thereby promoting an immunosuppressive microenvironment in the tumor tissue.
Jaehyun, Park +2 more
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Proceedings of the 31st Annual ACM Symposium on Applied Computing, 2016
Text mining is widely used to infer relationships between biological entities. Most text-mining algorithms utilize a co-occurrence-based approach. The term co-occurrence denotes a relationship between two interesting entities if they appear in the same sentence.
Jeongwoo Kim +2 more
openaire +1 more source
Text mining is widely used to infer relationships between biological entities. Most text-mining algorithms utilize a co-occurrence-based approach. The term co-occurrence denotes a relationship between two interesting entities if they appear in the same sentence.
Jeongwoo Kim +2 more
openaire +1 more source
Light‐Triggered PROTAC Nanoassemblies for Photodynamic IDO Proteolysis in Cancer Immunotherapy
Advances in MaterialsWhile proteolysis‐targeting chimeras (PROTACs) hold great potential for persistently reprogramming the immunosuppressive tumor microenvironment via targeted protein degradation, precisely activating them in tumor tissues and preventing uncontrolled ...
Jiwoong Choi +10 more
semanticscholar +1 more source
Trends in Molecular Medicine, 2004
Tumors create a pathological state of tolerance towards tumor-associated antigens. The mechanisms by which this occurs are still largely unknown. Recent studies suggest that one mechanism contributing to this phenomenon could be tryptophan catabolism carried out by the immunoregulatory enzyme indoleamine 2,3-dioxygenase (IDO).
David H, Munn, Andrew L, Mellor
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Tumors create a pathological state of tolerance towards tumor-associated antigens. The mechanisms by which this occurs are still largely unknown. Recent studies suggest that one mechanism contributing to this phenomenon could be tryptophan catabolism carried out by the immunoregulatory enzyme indoleamine 2,3-dioxygenase (IDO).
David H, Munn, Andrew L, Mellor
openaire +2 more sources
Blood, 2008
In this issue of Blood , Jasperson and colleagues show that indoleamine 2,3-dioxygenase (IDO) is a novel component of the inhibition of T-cell activation after allogeneic stem-cell transplantation, and offer a rationale for innovative strategies in the management of GVHD targeting this pathway.
CURTI, ANTONIO +2 more
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In this issue of Blood , Jasperson and colleagues show that indoleamine 2,3-dioxygenase (IDO) is a novel component of the inhibition of T-cell activation after allogeneic stem-cell transplantation, and offer a rationale for innovative strategies in the management of GVHD targeting this pathway.
CURTI, ANTONIO +2 more
openaire +2 more sources
Nano letters (Print), 2019
Immunotherapy through stimulating host immune system has emerged as a powerful therapeutic strategy for various malignant and metastatic tumors in clinic. However, harnessing the immune system for cancer treatment often fails to obtain a durable response
Dechun Liu +6 more
semanticscholar +1 more source
Immunotherapy through stimulating host immune system has emerged as a powerful therapeutic strategy for various malignant and metastatic tumors in clinic. However, harnessing the immune system for cancer treatment often fails to obtain a durable response
Dechun Liu +6 more
semanticscholar +1 more source
IDO+ DCs and Signalling Pathways
Current Cancer Drug Targets, 2013Dendritic cells (DCs) have traditionally been viewed as constituting an 'information management' system that functions solely to integrate a diverse array of incoming signals, in order to induce immune reactivity. In recent years, however, there has been a shift towards viewing these cells as key regulators in the orchestration of immunological ...
Yue, Wang +5 more
openaire +2 more sources
Clinical Cancer Research
Summary Indoleamine 2,3-dioxygenase 1 is central to immune downregulation. A recent phase I/II study tested the indoleamine 2,3-dioxygenase 1 inhibitor linrodostat with nivolumab ± ipilimumab in patients with advanced solid tumors. Although efficacy was not augmented, correlative analyses identified tryptophan 2,3 dioxygenase as a ...
Peter D. Zang, Tanya B. Dorff
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Summary Indoleamine 2,3-dioxygenase 1 is central to immune downregulation. A recent phase I/II study tested the indoleamine 2,3-dioxygenase 1 inhibitor linrodostat with nivolumab ± ipilimumab in patients with advanced solid tumors. Although efficacy was not augmented, correlative analyses identified tryptophan 2,3 dioxygenase as a ...
Peter D. Zang, Tanya B. Dorff
openaire +2 more sources
Nature Medicine, 1998
A recent study suggests that immunosuppression mediated by IDO, an enzyme that catabolizes tryptophan, may prevent rejection of the fetus by the maternal immune system.
Elizabeth A. Bonney, Polly Matzinger
openaire +1 more source
A recent study suggests that immunosuppression mediated by IDO, an enzyme that catabolizes tryptophan, may prevent rejection of the fetus by the maternal immune system.
Elizabeth A. Bonney, Polly Matzinger
openaire +1 more source