Results 31 to 40 of about 94,816 (308)

Granulocytic sarcoma: Extramedullary manifestation of chronic myeloproliferative neoplasm in a young African woman

Human Pathology: Case Reports, 2021
We present a rare case of multiple granulocytic sarcoma in a young African woman in blast phase of chronic myeloproliferative neoplasm. Fine needle aspiration cytology of the sarcoma, peripheral blood film and bone marrow aspiration cytology were ...
Ajayi A. Ibijola, Abiodun I. Okunlola, Abiodun O. Awe   +2 more
doaj   +1 more source

Tolerogenic Phenotype of IFN-γ–Induced IDO+ Dendritic Cells Is Maintained via an Autocrine IDO–Kynurenine/AhR–IDO Loop [PDF]

The Journal of Immunology, 2016
Abstract Previous studies demonstrated that IL-12–driven antitumor activity is short-circuited by a rapid switch in dendritic cell (DC) function from immunogenic to tolerogenic activity. This process was dependent on IFN-γ and the tolerogenic phenotype was conferred by IDO. Extended monitoring of IDO+ DC in the tumor-draining lymph nodes
Qingsheng Li, Jamie L Harden, Charles D Anderson, Nejat K Egilmez   +3 more
openaire   +2 more sources

Characterizing the distributions of IDO-1 expressing macrophages/microglia in human and murine brains and evaluating the immunological and physiological roles of IDO-1 in RAW264.7/BV-2 cells

PLoS ONE, 2021
Indoleamine 2,3-dioxygenase 1 (IDO-1) is an immunosuppressive enzyme expressed in the placenta, neoplastic cells, and macrophages to reject T cells by converting tryptophan into kynurenine.
Rong Ji, Lixiang Ma, Xinyu Chen, Renqiang Sun, Li Zhang, H. Saiyin, Wenshi Wei   +6 more
semanticscholar   +1 more source

(Acetylacetonato)dibromido[2,2-diphenylhydrazin-1-ido(1−)][2,2-diphenylhydrazin-1-ido(2−)]molybdenum(VI) [PDF]

Acta Crystallographica Section E Structure Reports Online, 2011
In the title compound, [MoBr(2)(C(12)H(11)N(2))(C(12)H(10)N(2))(C(5)H(7)O(2))], the Mo(VI) atom is six-coordinated in a distorted octa-hedral geometry by two N atoms from the diphenyl-hydrazide(1-) and diphenyl-hydrazide(2-) ligands, two O atoms from a bidentate acetyl-acetonate ligand and two Br(-) ions.
Bustos, Carlos, Alvarez-Thon, Luis, Ibanez, Andres, Sanchez, Christian   +3 more
openaire   +6 more sources

Geriatric neurosurgery in a suburban community: A preliminary review of a single neurosurgeon experience

Interdisciplinary Neurosurgery, 2021
Background: Geriatric medicine is a growing specialty but the cut off age varies all over the world due to the variation in life expectancy. Neurosurgical procedures in this vulnerable age group pose remarkable challenges and require collaborative ...
Abiodun Idowu Okunlola, Cecilia Kehinde Okunlola, Olakunle Fatai Babalola, Tesleem Olayinka Orewole, Akinola Akinmade, Olasunbo Oluwaseun Kofoworola   +5 more
doaj   +1 more source

Targeting Overexpressed IDO in Stromal Cells as a Potential Therapeutic Strategy in Multiple Myeloma. [PDF]

Cancer Sci
IDO expression in stromal cells was upregulated by MM cells via the JAK–STAT1–NF‐κB–IRF1 signaling pathway. JAK inhibitor abolished IDO and IRF1 upregulation. ABSTRACT Stromal cells are an essential component of the tumor microenvironment (TME) in multiple myeloma (MM). Indoleamine 2,3‐dioxygenase 1 (IDO), an enzyme that metabolizes tryptophan (Trp) to
Ebina T, Ri M, Marumo Y, Nakamura T, Sasaki H, Oshima Y, Nakashima T, Hagiwara S, Asano A, Kinoshita S, Suzuki T, Narita T, Masaki A, Sanda T, Yamagata K, Kubo K, Komatsu H, Sakuraba H, Iida S.   +18 more
europepmc   +2 more sources

Pattern of Skin Cancers in a Tertiary Medical Center in Southwest Nigeria

The Annals of African Surgery, 2022
Background: Skin cancers are the most common malignancies in the western world, and their incidence is increasing globally. However, the data about the pattern in sub-Saharan Africa are limited.
Adedayo Idris Salawu, Olakunle Fatai Babalola, Oladipo Omoseebi, Olagoke Erinomo, Tope Michael Ipinnimo, Adeniyi Steven Hassan, Shiyanbola Akinlolu Christopher   +6 more
doaj   +1 more source

Photosensitizer Micelles Together with IDO Inhibitor Enhance Cancer Photothermal Therapy and Immunotherapy

Advancement of science, 2018
The therapeutic outcome of photothermal therapy (PTT) remains impeded by the transparent depth of light. Combining PTT with immunotherapy provides strategies to solve this problem.
Jinrong Peng, Yao Xiao, Wenting Li, Qian Yang, Liwei Tan, Yan-peng Jia, Y. Qu, Z. Qian   +7 more
semanticscholar   +1 more source

Commentary: preclinical efficacy of immune-checkpoint monotherapy does not recapitulate corresponding biomarkers-based clinical predictions in glioblastoma by Garg et al. (2017)

OncoImmunology, 2019
Preclinical modeling and gene expression analyses have yielded distinct observations for the role of immune checkpoint, IDO1, in glioblastoma (GBM). Accordingly, our recent work differs with Garg et al.
Lijie Zhai, Erik Ladomersky, Kristen L. Lauing, Meijing Wu, Denise M. Scholtens, Rohan Savoor, Bin Zhang, Jennifer D. Wu, Craig Horbinski, Rimas V. Lukas, David C. Binder, Derek A. Wainwright   +11 more
doaj   +1 more source

Bacteriological profile and antibiogram of blood culture isolates from bloodstream infections in a rural tertiary hospital in Nigeria

African Journal of Laboratory Medicine, 2022
Background: Bloodstream infections (BSIs) are a cause of significant morbidity and mortality requiring urgent antibiotic treatment. However, there is widespread antibiotic-resistance from the bacterial causes, necessitating regular surveillance for drug ...
Oluwalana T. Oyekale, Bola O. Ojo, Adewale T. Olajide, Oluwatoyin I. Oyekale   +3 more
doaj   +1 more source