Results 41 to 50 of about 94,816 (308)
Science-Business eXchange, 2009 Researchers at Incyte Corp. have identified a class of IDO inhibitors to treat cancer that they think could be more potent than the only disclosed IDO inhibitor in the clinic, which is from NewLink Genetics Corp.
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Role of IDO and TDO in Cancers and Related Diseases and the Therapeutic Implications
Journal of Cancer, 2019 Kynurenine (Kyn) pathway is a significant metabolic pathway of tryptophan (Trp). The metabolites of the Kyn pathway are closely correlated with numerous diseases.
Zixiang Ye +4 more
semanticscholar +1 more source
OncoImmunology, 2017 Novel systemic treatments for hepatocellular carcinoma (HCC) are strongly needed. Immunotherapy is a promising strategy that can induce specific antitumor immune responses.
Kostandinos Sideras +19 more
doaj +1 more source
Multimodal Transportation, 2022 Cities across the world are expanding as a result of urbanization, resulting in growing demand for goods and services, mainly through online sales. This has resulted in the need for an urban consolidation center (UCC) to minimize travel and optimize ...
Oyegoke Teslim Bukoye, Sathvik Gadiraju
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Ibom Medical Journal, 2022 Background: Diabetes Mellitus is a non-communicable disease and a leading cause of morbidity and mortality in the world. The estimated prevalence of diabetes in Africa is 1% in rural areas and ranges from 5% to 7% in urban sub-Saharan Africa.
Elegbede OE, Sanni TA, Alabi AK
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Awake craniotomy in neurosurgery: Shall we do it more often?
Interdisciplinary Neurosurgery, 2020 Background: Awake craniotomy allows intraoperative cortical mapping to prevent injury to the eloquent brain region and minimizes the complications of general anaesthesia.
Abiodun Idowu Okunlola +5 more
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IDO activation, inflammation and musculoskeletal disease [PDF]
Experimental Gerontology, 2020 The IDO/kynurenine pathway is now established as a major regulator of immune system function. The initial enzyme, indoleamine 2,3-dioxygenase (IDO1) is induced by IFNγ, while tryptophan-2,3-dioxygenase (TDO) is induced by corticosteroids. The pathway is therefore positioned to mediate the effects of systemic inflammation or stress-induced steroids on ...
Ogbechi, J +5 more
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Advanced Healthcare Materials, EarlyView.Bioengineering tumor‐stroma pancreatic cancer models with potential to emulate the native immunosuppressive tumor microenvironment. Cancer‐on‐a‐bead models exhibited higher relevance for screening immunotherapies and modulating the protumoral PDAC microenvironment. ABSTRACT Pancreatic cancer is notably resistant to treatment, primarily due to its dense
Maria V. Monteiro +4 more
wiley +1 more source
Clinical Cancer Research, 2018 Significant progress has been made in cancer immunotherapy with checkpoint inhibitors targeting programmed cell death protein 1 (PD-1)–programmed death-ligand 1 signaling pathways.
Brian W. Labadie, R. Bao, J. Luke
semanticscholar +1 more source
Advanced Robotics Research, EarlyView.Permanent magnet putty (PMP) integrates high‐coercivity NdFeB particles with a dynamic polyborosiloxane–Ecoflex matrix, achieving rapid self‐healing (90% mechanical recovery in 10 s) and magnetic recovery within 20 min. With twice the sensitivity of commercial putties, PMP enables precise 5–30 N force detection and discrimination between pressing and ...
Ruotong Zhao +5 more
wiley +1 more source