Results 61 to 70 of about 297,239 (298)
Sensors, 2020 Applying Software Engineering (SE) processes is vital to critical and complex systems including security and networking systems. Nowadays, Wireless Sensor Networks (WSNs) and their applications are found in many military and civilian systems which make ...
Iman Almomani, Afnan Alromi
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
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Table of Contents Vol 53, No 1, 2, 3 & 4 (2019)
In die Skriflig, 2019 No abstract available.
Editorial Office
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
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Journal of Forest Science, 2009 The combination of georeferenced colour aerial photos and limited field measurements of individual trees was used to determine tree stand biomass in forests of prevailing Norway spruce.
K. Matějka
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
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Hematology, Transfusion and Cell TherapyIntroduction/Justification: Prostate cancer is among the most common cancers in males. The PSMA (Prostate-Specific Membrane Antigen), a protein expressed in prostate cancer cells, has been used in the control of that cancer and can also be taken up in ...
Beatriz Birelli do Nascimento +5 more
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Measuring symptoms of post-traumatic stress disorder in people with intellectual disabilities: the development and psychometric properties of the Impact of Event Scale – Intellectual Disabilities (IES-IDs) [PDF]
, 2014 Background: The aims of the study were to (a) revise the Impact of Event Scale – Revised for use with people with intellectual disabilities (IDs), creating the Impact of Event Scale – Intellectual Disabilities (IES-IDs), (b) assess the reliability of the
Langdon, Peter E. +4 more
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