Results 51 to 60 of about 297,239 (298)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Systematic literature review on intrusion detection systems: Research trends, algorithms, methods, datasets, and limitations

Journal of Intelligent Systems
Machine learning (ML) and deep learning (DL) techniques have demonstrated significant potential in the development of effective intrusion detection systems.
Issa Melad Mohammed, Aljanabi Mohammad, Muhialdeen Hassan M.   +2 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Sistema integrado para toma de decisiones en el diseño de estructuras de hormigón

Informes de la Construccion, 2012
El presente artículo hace una breve reflexión sobre las alternativas in situ y prefabricadas para estructuras de hormigón, justificando la necesidad de profundizar en métodos multicriterio como ayuda a la toma de decisiones.
J. Armengou, A. Aguado, G. Ormazábal
doaj   +1 more source

Framework for identifying network attacks through packet inspection using machine learning

Nonlinear Engineering, 2023
In every network, traffic anomaly detection system is an essential field of study. In the communication system, there are various protocols and intrusions. It is still a testing area to find high precision to boost the correct distribution ratio.
Shanker Ravi, Agrawal Prateek, Singh Aman, Bhatt Mohammed Wasim   +3 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

EBH-HE-IDS

, 2021
EBH-HE-IDS is a new publicly available Enteroscope Biopsy Histopathological Hematoxylin and Eosin Image Dataset of 5532 electron microscopy images of histopathological sections of colorectal cancer, including five tumor differentiation stages.
MIaMIA Group (11195799)
core   +1 more source

Humoral anti-SARS-CoV-2 immune response for different strains after Sinovac-CoronaVac and Oxford/AstraZeneca (ChAdOx1-S) full vaccination on a healthcare population in Brazil

Revista Uningá
COVID-19, caused by the SARS-CoV-2 virus, is a global respiratory syndrome with high mortality rates. Vaccination is currently the only proven method to prevent the disease, although the role of lab data in assessing efficacy remains uncertain.
Maicon Jeferson Silva de Oliveira, Beatriz Birelli do Nascimento, Fernanda de Assis Oliveira, Mahelly Bueno de Almeida, Márcio Rodrigues, Flavia Cristina Cardoso Carvalho, Éric Diego Barioni, Rodrigo Azevedo Loiola, Rômulo Tadeu Dias de Oliveira, Gustavo Henrique Oliveira da Rocha   +9 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source