Results 91 to 100 of about 208,098 (169)

Bioinformatic RNA-Seq Functional Profiling of the Tumor Suppressor Gene OPCML in Ovarian Cancers: The Multifunctional, Pleiotropic Impacts of Having Three Ig Domains

Current Issues in Molecular Biology
The IgLON family of tumor suppressor genes (TSG) impact a variety of cellular processes involved in cancer and non-cancer biology. OPCML is a member of this family and its inactivation is an important control point in oncogenesis and tumor growth.
Adam G. Marsh, Franziska Görtler, Sassan Hafizi, Hani Gabra   +3 more
doaj   +1 more source

ERMAP attenuates DSS-induced colitis in mice by regulating macrophage and T cell functions

BMC Gastroenterology
Background & aims Both macrophages and T cells play a critical role in inflammatory bowel disease (IBD) development. Since our previous studies have shown that a novel immune checkpoint molecule erythrocyte membrane-associated protein (ERMAP) affects ...
Lu Xia, Yiwen Pan, Xianbin Wang, Rong Hu, Jie Gao, Wei Chen, Keke He, Dongbin Cui, Youbo Zhao, Lu Liu, Laijun Lai, Min Su   +11 more
doaj   +1 more source

P033 | Double marker strategy to measurable residual disease assessment in Philadelphia-like acute lymphoblastic leukemia

Haematologica
Introduction. Philadelphia-like acute lymphoblastic leukemia (Ph-like ALL) exhibits a gene expression profile resembling that of Ph+ ALL, furthermore, most cases harbor distinct fusion genes involving tyrosine kinases or cytokine receptor rearrangements.
Deborah Cardinali
doaj  

Filtering Next-Generation Sequencing of the Ig Gene Repertoire Data Using Antibody Structural Information. [PDF]

J Immunol, 2018
Kovaltsuk A, Krawczyk K, Kelm S, Snowden J, Deane CM.   +4 more
europepmc   +1 more source

TIGIT expression in extrahepatic cholangiocarcinoma and its impact on CD8 + T cell exhaustion: implications for immunotherapy

Cell Death and Disease
Extrahepatic cholangiocarcinoma (ECCA) is a malignant tumor. The precise role of T-cell immunoreceptor with Ig and ITIM domains (TIGIT), an emerging immunosuppressive receptor, in ECCA, and its impact on CD8+ T cell exhaustion (Tex) remains unclear.
Tengqian Tang, Wenhao Wang, Lang Gan, Jie Bai, Dehong Tan, Yan Jiang, Ping Zheng, Weijun Zhang, Yu He, Qianfei Zuo, Leida Zhang   +10 more
doaj   +1 more source

Colonic spatial single-cell proteomics and murine models link mitochondrial dysfunction to dimeric IgA-secreting plasma cell deficiency in Crohn’s disease

Nature Communications
Secretory IgA (SIgA) is critical for maintaining the intestinal barrier. A dysregulated B-cell compartment and altered Ig secretion have been well documented in Crohn’s disease (CD) patients, although their origin is unknown.
Annika Raschdorf, Larissa Nogueira de Almeida, Philipp Solbach, Martha M. Kirstein, Jens U. Marquardt, Franziska Schmelter, Ulrich L. Günther, Heidi Schlichting, Maren Hicken, Lea Christiansen, Miriam Wiestler, Hauke C. Tews, Dominik Bettenworth, OUTLIVE-CRC consortium, Matthias Peipp, Thomas Valerius, Mohab Ragab, Thorben Sauer, Timo Gemoll, Marc Ehlers, Philip Rosenstiel, Rudolf A. Manz, Axel Künstner, Hauke Busch, Christian Sina, Stefanie Derer   +25 more
doaj   +1 more source

Identification of novel immune-related signatures for keloid diagnosis and treatment: insights from integrated bulk RNA-seq and scRNA-seq analysis

Human Genomics
Background Keloid is a disease characterized by proliferation of fibrous tissue after the healing of skin tissue, which seriously affects the daily life of patients.
Kui Xiao, Sisi Wang, Wenxin Chen, Yiping Hu, Ziang Chen, Peng Liu, Jinli Zhang, Bin Chen, Zhi Zhang, Xiaojian Li   +9 more
doaj   +1 more source

CPG RNAi knockdown RNA-seq

, 2019
RNA-seq after knockdown of a cuticle ...
USDA (17854931)
core  

Ig-microbiota binding patterns in mothers and infants: a scoping review. [PDF]

Gut Microbiome (Camb)
Yi Jia AT, Peacock CS, Dye DE, Christophersen CT.   +3 more
europepmc   +1 more source

Multi-omics reveal vitamin D regulation of immune-gut microbiome interactions and tolerogenic pathways in inflammatory bowel disease. [PDF]

Cell Rep Med
Gubatan J, Sojwal RS, Ye J, Boye TL, Hoang JN, Fardeen T, Temby M, Rubin SJS, Spencer SP, Kotagiri P, Rogalla S, Rosen MJ, Nielsen OH, Boyd S, Sonnenburg J, Sinha SR.   +15 more
europepmc   +1 more source