Results 1 to 10 of about 85,484 (110)
Understanding the human antibody repertoire [PDF]
mAbs, 2020 The origins of the various elements in the human antibody repertoire have been and still are subject to considerable uncertainty. Uncertainty in respect of whether the various elements have always served a specific defense function or whether they were ...
Anthony R Rees
doaj +4 more sources
Antibody repertoire sequencing analysis [PDF]
Acta Biochimica et Biophysica Sinica, 2022 High-throughput sequencing for B cell receptor (BCR) repertoire provides useful insights for the adaptive immune system. With the continuous development of the BCR-seq technology, many efforts have been made to develop methods for analyzing the ever ...
Zhang Senxin +4 more
doaj +2 more sources
Explore antibody repertoire in the era of AI [PDF]
Acta Biochimica et Biophysica SinicaThe diverse antibodies of adaptive immunity comprise an antibody repertoire that combats various pathogens. This repertoire is shaped by both intrinsic antibody gene diversification and extrinsic cellular selection.
Zhang Yudi +3 more
doaj +2 more sources
Genetic variation in the immunoglobulin heavy chain locus shapes the human antibody repertoire [PDF]
Nature Communications, 2023 Variation in the antibody response has been linked to differential outcomes in disease, and suboptimal vaccine and therapeutic responsiveness, the determinants of which have not been fully elucidated.
Oscar L. Rodriguez +12 more
doaj +2 more sources
Frontiers in Immunology, 2022 Immunoproteomics has emerged as a versatile tool for analyzing the antibody repertoire in various disease contexts. Until recently, characterization of antibody molecules in biological fluids was limited to bulk serology, which identifies clinically ...
Steven Ionov, Jiwon Lee
doaj +3 more sources
Frontiers in Immunology, 2021 The role of B cells in the tumor microenvironment (TME) has largely been under investigated, and data regarding the antibody repertoire encoded by B cells in the TME and the adjacent lymphoid organs are scarce.
Ligal Aizik +5 more
doaj +3 more sources
Antibody repertoire profiling with mimotope arrays
Human Vaccines & Immunotherapeutics, 2017 Large-scale profiling and monitoring of antibody repertoires is possible through next generation sequencing (NGS), phage display libraries and microarrays.
Shina Pashova +3 more
doaj +2 more sources
Toll-like receptor 7/8 agonist stimulation rapidly skews the antibody repertoire of B cells in non-human primates [PDF]
Frontiers in ImmunologyIntroductionToll-like receptors 7 and 8(TLR7/8) recognize purine-rich single-stranded RNA from pathogens, triggering immune responses. Although TLR7/8 agonists are emerging as potential novel adjuvants, their impact on the adaptive B cell response ...
Shiyu Wang +5 more
doaj +2 more sources
Evolution of SARS-CoV-2 antibody repertoire after successive mRNA vaccinations under immunosuppressive treatment [PDF]
EBioMedicineJim B D Keijser +2 more
exaly +2 more sources
Comprehensive evaluation and optimization of amplicon library preparation methods for high-throughput antibody sequencing. [PDF]
PLoS ONE, 2014 High-throughput sequencing (HTS) of antibody repertoire libraries has become a powerful tool in the field of systems immunology. However, numerous sources of bias in HTS workflows may affect the obtained antibody repertoire data.
Ulrike Menzel +8 more
doaj +1 more source