Results 1 to 10 of about 22,840 (120)

The Pipeline Repertoire for Ig-Seq Analysis [PDF]

Frontiers in Immunology, 2019
With the advent of high-throughput sequencing of immunoglobulin genes (Ig-Seq), the understanding of antibody repertoires and their dynamics among individuals and populations has become an exciting area of research.
Laura López-Santibáñez-Jácome, Laura López-Santibáñez-Jácome, S. Eréndira Avendaño-Vázquez, Carlos Fabián Flores-Jasso   +3 more
doaj   +5 more sources

Multimodal single-cell protein and RNA profiling unveils dysregulated immature neutrophil dynamics in gestational diabetes mellitus [PDF]

Communications Biology
Neutrophils are the most abundant leukocytes in human peripheral blood, yet their heterogeneity in pregnancy, especially in gestational diabetes mellitus (GDM), remains incompletely understood.
Junyu Xu, Caixia Zhu, Lepei Xie, Yiping Liu, Jinheng Li, Lu Wang, Lisha Ye, Yannan Zhang, Zilian Wang, Limin Zheng, Chong Wu, Haitian Chen   +11 more
doaj   +2 more sources

Large-scale analysis of 2,152 Ig-seq datasets reveals key features of B cell biology and the antibody repertoire [PDF]

Cell Reports, 2021
Antibody repertoire sequencing enables researchers to acquire millions of B cell receptors and investigate these molecules at the single-nucleotide level. This power and resolution in studying humoral responses have led to its wide applications. However, most of these studies were conducted with a limited number of samples.
Xiujia Yang, Minhui Wang, Jiaqi Wu, Dianchun Shi, Yanfang Zhang, Huikun Zeng, Yan Zhu, Chunhong Lan, Yang Deng, Shixin Guo, Lijun Xu, Cuiyu Ma, Yanxia Zhang, Jinxia Ou, Chu-jun Liu, Yuan Chen, Qilong Wang, Wenxi Xie, Junjie Guan, Jieyu Ding, Zhi Wang, Changqing Chang, Wei Yang, Huijie Zhang, Jun Chen, Lijie Qin, Hongwei Zhou, Jin-Xin Bei, Lai Wei, Guangwen Cao, Xueqing Yu, Zhenhai Zhang   +31 more
openaire   +2 more sources

Novel Allele Detection Tool Benchmark and Application With Antibody Repertoire Sequencing Dataset

Frontiers in Immunology, 2021
Detailed knowledge of the diverse immunoglobulin germline genes is critical for the study of humoral immunity. Hundreds of alleles have been discovered by analyzing antibody repertoire sequencing (Rep-seq or Ig-seq) data via multiple novel allele ...
Xiujia Yang, Xiujia Yang, Xiujia Yang, Xiujia Yang, Yan Zhu, Sen Chen, Sen Chen, Huikun Zeng, Huikun Zeng, Junjie Guan, Junjie Guan, Qilong Wang, Qilong Wang, Chunhong Lan, Deqiang Sun, Xueqing Yu, Xueqing Yu, Zhenhai Zhang, Zhenhai Zhang, Zhenhai Zhang, Zhenhai Zhang, Zhenhai Zhang   +21 more
doaj   +1 more source

Current strategies for detecting functional convergence across B-cell receptor repertoires

mAbs, 2021
Convergence across B-cell receptor (BCR) and antibody repertoires has become instrumental in prioritizing candidates in recent rapid therapeutic antibody discovery campaigns.
Matthew I. J. Raybould, Anthony R. Rees, Charlotte M. Deane   +2 more
doaj   +1 more source

Adaptive immune receptor genotyping using the corecount program

Frontiers in Immunology, 2023
We present a new Rep-Seq analysis tool called corecount, for analyzing genotypic variation in immunoglobulin (IG) and T cell receptor (TCR) genes. corecount is highly efficient at identifying V alleles, including those that are infrequently used in ...
Sanjana Narang, Mateusz Kaduk, Mark Chernyshev, Gunilla B. Karlsson Hedestam, Martin M. Corcoran   +4 more
doaj   +1 more source

Differential programming of B cells in AID deficient mice. [PDF]

PLoS ONE, 2013
The Aicda locus encodes the activation induced cytidine deaminase (AID) and is highly expressed in germinal center (GC) B cells to initiate somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin (Ig) genes.
Marc A Hogenbirk, Marinus R Heideman, Arno Velds, Paul C M van den Berk, Ron M Kerkhoven, Bas van Steensel, Heinz Jacobs   +6 more
doaj   +1 more source

Profiling genes encoding the adaptive immune receptor repertoire with gAIRR Suite

Frontiers in Immunology, 2022
Adaptive immune receptor repertoire (AIRR) is encoded by T cell receptor (TR) and immunoglobulin (IG) genes. Profiling these germline genes encoding AIRR (abbreviated as gAIRR) is important in understanding adaptive immune responses but is challenging ...
Mao-Jan Lin, Mao-Jan Lin, Yu-Chun Lin, Nae-Chyun Chen, Allen Chilun Luo, Sheng-Kai Lai, Chia-Lang Hsu, Chia-Lang Hsu, Chia-Lang Hsu, Jacob Shujui Hsu, Chien-Yu Chen, Wei-Shiung Yang, Wei-Shiung Yang, Wei-Shiung Yang, Wei-Shiung Yang, Pei-Lung Chen, Pei-Lung Chen, Pei-Lung Chen, Pei-Lung Chen, Pei-Lung Chen   +19 more
doaj   +1 more source

Exploiting B Cell Receptor Analyses to Inform on HIV-1 Vaccination Strategies

Vaccines, 2020
The human antibody repertoire is generated by the recombination of different gene segments as well as by processes of somatic mutation. Together these mechanisms result in a tremendous diversity of antibodies that are able to combat various pathogens ...
Christoph Kreer, Henning Gruell, Thierry Mora, Aleksandra M. Walczak, Florian Klein   +4 more
doaj   +1 more source

Stage-Specific Non-Coding RNA Expression Patterns during In Vitro Human B Cell Differentiation into Antibody Secreting Plasma Cells

Non-Coding RNA, 2022
The differentiation of B cells into antibody secreting plasma cells (PCs) is governed by a strict regulatory network that results in expression of specific transcriptomes along the activation continuum. In vitro models yielding significant numbers of PCs
Renee C. Tschumper, Dominique B. Hoelzinger, Denise K. Walters, Jaime I. Davila, Collin A. Osborne, Diane F. Jelinek   +5 more
doaj   +1 more source