Results 11 to 20 of about 208,098 (169)

How B-Cell Receptor Repertoire Sequencing Can Be Enriched with Structural Antibody Data

Frontiers in Immunology, 2017
Next-generation sequencing of immunoglobulin gene repertoires (Ig-seq) allows the investigation of large-scale antibody dynamics at a sequence level. However, structural information, a crucial descriptor of antibody binding capability, is not collected ...
Aleksandr Kovaltsuk, Konrad Krawczyk, Jacob D. Galson, Dominic F. Kelly, Charlotte M. Deane, Johannes Trück   +5 more
doaj   +1 more source

RNA Sequences-Based Diagnosis of Parkinson’s Disease Using Various Feature Selection Methods and Machine Learning

Applied Sciences, 2023
Parkinson’s disease is a neurodegenerative disease that is associated with genetic and environmental factors. However, the genes causing this degeneration have not been determined, and no reported cure exists for this disease. Recently, studies have been
Jingeun Kim, Hye-Jin Park, Yourim Yoon
doaj   +1 more source

Methods, Challenges and Potentials of Single Cell RNA-seq [PDF]

, 2012
RNA-sequencing (RNA-seq) has become the tool of choice for transcriptomics. Several recent studies demonstrate its successful adaption to single cell analysis. This allows new biological insights into cell differentiation, cell-to-cell variation and gene
Daniel Hebenstreit, Hebenstreit, Daniel
core   +1 more source

Synthetic Standards Combined With Error and Bias Correction Improve the Accuracy and Quantitative Resolution of Antibody Repertoire Sequencing in Human Naïve and Memory B Cells

Frontiers in Immunology, 2018
High-throughput sequencing of immunoglobulin (Ig) repertoires (Ig-seq) is a powerful method for quantitatively interrogating B cell receptor sequence diversity.
Simon Friedensohn, John M. Lindner, Vanessa Cornacchione, Mariavittoria Iazeolla, Enkelejda Miho, Andreas Zingg, Simon Meng, Elisabetta Traggiai, Sai T. Reddy   +8 more
doaj   +1 more source

Characterization of DNA G-Quadruplex Structures in Human Immunoglobulin Heavy Variable (IGHV) Genes

Frontiers in Immunology, 2021
Activation-induced deaminase (AID) is a key enzyme involved in antibody diversification by initiating somatic hypermutation (SHM) and class-switch recombination (CSR) of the Immunoglobulin (Ig) loci.
Catherine Tang, Thomas MacCarthy, Thomas MacCarthy   +2 more
doaj   +1 more source

Accounting for immunoprecipitation efficiencies in the statistical analysis of ChIP-seq data [PDF]

, 2013
Background: ImmunoPrecipitation (IP) efficiencies may vary largely between different antibodies and between repeated experiments with the same antibody.
Bao, Yanchun,, ’t Hoen, Peter AC, Bao, Yanchun, Veronica Vinciotti, Hoen, P.A.C. 't, Vinciotti, V., Vinciotti, Veronica,, Yanchun Bao, Wit, Ernst,, Bao, Y.C., Ernst Wit, Wit, Ernst, Vinciotti, V, Peter AC ’t Hoen, 't Hoen, Peter A C, Vinciotti, Veronica, Hoen, Peter A.C. ’t,, Bao, Y, 't Hoen, PAC, Wit, E, Wit, E.   +20 more
core   +1 more source

AncesTree: An interactive immunoglobulin lineage tree visualizer.

PLoS Computational Biology, 2020
High-throughput sequencing of human immunoglobulin genes allows analysis of antibody repertoires and the reconstruction of clonal lineage evolution. The study of antibodies (Abs) affinity maturation is of specific interest to understand the generation of
Mathilde Foglierini, Leontios Pappas, Antonio Lanzavecchia, Davide Corti, Laurent Perez   +4 more
doaj   +1 more source

Structurally Mapping Antibody Repertoires

Frontiers in Immunology, 2018
Every human possesses millions of distinct antibodies. It is now possible to analyze this diversity via next-generation sequencing of immunoglobulin genes (Ig-seq).
Konrad Krawczyk, Sebastian Kelm, Aleksandr Kovaltsuk, Jacob D. Galson, Dominic Kelly, Johannes Trück, Johannes Trück, Cristian Regep, Jinwoo Leem, Wing K. Wong, Jaroslaw Nowak, James Snowden, Michael Wright, Laura Starkie, Anthony Scott-Tucker, Jiye Shi, Charlotte M. Deane   +16 more
doaj   +1 more source

ajing0731/DO-Seq: DO-seq

, 2023
Repo for source codes in DO-seq ...
Ajing
core   +1 more source

Inferred Allelic Variants of Immunoglobulin Receptor Genes: A System for Their Evaluation, Documentation, and Naming

Frontiers in Immunology, 2019
Immunoglobulins or antibodies are the main effector molecules of the B-cell lineage and are encoded by hundreds of variable (V), diversity (D), and joining (J) germline genes, which recombine to generate enormous IG diversity.
Mats Ohlin, Cathrine Scheepers, Cathrine Scheepers, Martin Corcoran, William D. Lees, Christian E. Busse, Davide Bagnara, Linnea Thörnqvist, Jean-Philippe Bürckert, Katherine J. L. Jackson, Duncan Ralph, Chaim A. Schramm, Nishanth Marthandan, Felix Breden, Jamie Scott, Frederick A. Matsen IV, Victor Greiff, Gur Yaari, Steven H. Kleinstein, Scott Christley, Jacob S. Sherkow, Sofia Kossida, Marie-Paule Lefranc, Menno C. van Zelm, Corey T. Watson, Andrew M. Collins   +25 more
doaj   +1 more source