Results 31 to 40 of about 89,614 (291)

Memory B Cell Activation, Broad Anti-influenza Antibodies, and Bystander Activation Revealed by Single-Cell Transcriptomics

Cell Reports, 2020
Summary: Antibody memory protects humans from many diseases. Protective antibody memory responses require activation of transcriptional programs, cell proliferation, and production of antigen-specific antibodies, but how these aspects of the response are
Felix Horns, Cornelia L. Dekker, Stephen R. Quake   +2 more
doaj   +1 more source

Complex subsets but redundant clonality after B cells egress from spontaneous germinal centers

eLife, 2023
Affinity matured self-reactive antibodies are found in autoimmune diseases like systemic lupus erythematous. Here, we used fate-mapping reporter mice and single-cell transcriptomics coupled to antibody repertoire analysis to characterize the post ...
Carlos Castrillon, Lea Simoni, Theo van den Broek, Cees van der Poel, Elliot H Akama-Garren, Minghe Ma, Michael C Carroll   +6 more
doaj   +1 more source

Perturbations of the T-cell immune repertoire in kidney transplant rejection

Frontiers in Immunology, 2022
In this cross-sectional and longitudinal analysis of mapping the T-cell repertoire in kidney transplant recipients, we have investigated and validated T-cell clonality, immune repertoire chronology at rejection, and contemporaneous allograft biopsy ...
Tara K. Sigdel, Paul A. Fields, Juliane Liberto, Izabella Damm, Maggie Kerwin, Jill Hood, Parhom Towfighi, Marina Sirota, Harlan S. Robins, Minnie M. Sarwal   +9 more
doaj   +1 more source

Systematic analysis of human antibody response to ebolavirus glycoprotein shows high prevalence of neutralizing public clonotypes

Cell Reports, 2023
Summary: Understanding the human antibody response to emerging viral pathogens is key to epidemic preparedness. As the size of the B cell response to a pathogenic-virus-protective antigen is poorly defined, we perform deep paired heavy- and light-chain ...
Elaine C. Chen, Pavlo Gilchuk, Seth J. Zost, Philipp A. Ilinykh, Elad Binshtein, Kai Huang, Luke Myers, Stefano Bonissone, Samuel Day, Chandrahaas R. Kona, Andrew Trivette, Joseph X. Reidy, Rachel E. Sutton, Christopher Gainza, Summer Diaz, Jazmean K. Williams, Christopher N. Selverian, Edgar Davidson, Erica Ollmann Saphire, Benjamin J. Doranz, Natalie Castellana, Alexander Bukreyev, Robert H. Carnahan, James E. Crowe, Jr.   +23 more
doaj   +1 more source

Human monoclonal antibody combination against SARS coronavirus : synergy and coverage of escape mutants [PDF]

, 2006
Background: Experimental animal data show that protection against severe acute respiratory syndrome coronavirus (SARS-CoV) infection with human monoclonal antibodies (mAbs) is feasible.
Peiris, Joseph S. M., Cox Freek, Doerr, Hans Wilhelm, Brink, Edward van den, van den Brink Edward N, Hans Wilhelm Doerr, ter Meulen Jan, Doerr Hans Wilhelm, Cheung, Chung Y., de Kruif John, van Deventer, Els, Jaap Goudsmit, Leo L. M., Poon, Leo L M Poon, Marissen Wilfred E, Marissen, Wilfred E., Poon Leo L. M, van den Brink, Edward N., Chow Vincent T, Chung Y Cheung, Wolfgang Preiser, Leung, Cynthia S.W., Preiser, Wolfgang, Van Deventer, E, Bogaards Johannes A, Freek Cox, Wilfred E Marissen, Els van Deventer, Joseph S M Peiris, Chow, Tak-Kwong Vincent, Bakker, Arjen Q., Leung, CSW, Chow, Vincent T., de Kruif, John, Goudsmit Jaap, ter Meulen, Jan, Deventer, Els van, Kruif, John de, De Kruif, J, John de Kruif, Cynthia S W Leung, Jan ter Meulen, Bogaards, Johannes A., Cox, F, Preiser Wolfgang, Cox, Freek, Goudsmit, J, Peiris Joseph S. M, Poon, LLM, Cheung, CY, Johannes A Bogaards, Doerr, HW, van Deventer Els, Marissen, WE, Bakker Arjen Q, Peiris, Joseph S.M., Poon, Leo L. M., Leung Cynthia S. W, Chow, VT, Edward N van den Brink, Bogaards, JA, Vincent T Chow, Arjen Q Bakker, Poon, Leo L.M., Cheung Chung Y, Van Den Brink, EN, Peiris, Joseph Sriyal Malik, Ter Meulen, J, Leung, Cynthia S. W., Goudsmit, Jaap, Peiris, JSM, Meulen, Jan ter, Bakker, AQ, Preiser, W   +73 more
core   +1 more source

Immune repertoire fingerprinting by principal component analysis reveals shared features in subject groups with common exposures

BMC Bioinformatics, 2019
Background Advances in next-generation sequencing (NGS) of antibody repertoires have led to an explosion in B cell receptor sequence data from donors with many different disease states.
Alexander M. Sevy, Cinque Soto, Robin G. Bombardi, Jens Meiler, James E. Crowe   +4 more
doaj   +1 more source

Advances in the Isolation of Specific Monoclonal Rabbit Antibodies

Frontiers in Immunology, 2017
The rabbit monoclonal antibodies (mAbs) have advantages in pharmaceuticals and diagnostics with high affinity and specificity. During the past decade, many techniques have been developed for isolating rabbit mAbs, including single B cell antibody ...
Zaibao Zhang, Zaibao Zhang, Huijuan Liu, Huijuan Liu, Qian Guan, Lei Wang, Lei Wang, Hongyu Yuan, Hongyu Yuan   +8 more
doaj   +1 more source

IgM Antibody Repertoire Fingerprints in Mice Are Personalized but Robust to Viral Infection Status

Frontiers in Cellular and Infection Microbiology, 2020
Antibody repertoire sequencing provides a molecular fingerprint of current and past pathogens encountered by the immune system. Most repertoire studies in humans require measuring the B cell response in the blood, resulting in a large bias to the IgM ...
Alexander Yermanos, Alexander Yermanos, Nike Julia Kräutler, Alessandro Pedrioli, Ulrike Menzel, Victor Greiff, Tanja Stadler, Annette Oxenius, Sai T. Reddy   +8 more
doaj   +1 more source

Characterization of the naive murine antibody repertoire using unamplified high-throughput sequencing. [PDF]

PLoS ONE, 2018
Antibody specificity and diversity are generated through the enzymatic splicing of genomic gene segments within each B cell. Antibodies are heterodimers of heavy- and light-chains encoded on separate loci.
Trisha A Rettig, Claire Ward, Bailey A Bye, Michael J Pecaut, Stephen K Chapes   +4 more
doaj   +1 more source

Commonality despite exceptional diversity in the baseline human antibody repertoire [PDF]

, 2019
In principle, humans can produce an antibody response to any non-self-antigen molecule in the appropriate context. This flexibility is achieved by the presence of a large repertoire of naive antibodies, the diversity of which is expanded by somatic ...
Inderbitzin, Anne, Anne Inderbitzin, Bryan Briney, Collin Joyce, Briney, Bryan, Dennis R. Burton, Burton, Dennis R, Joyce, Collin   +7 more
core   +1 more source