Results 11 to 20 of about 89,614 (291)
The Antibody Repertoire of Colorectal Cancer [PDF]
Molecular & Cellular Proteomics, 2017 Immunotherapy is becoming increasingly important in the fight against cancers, utilizing and manipulating the body's immune response to treat tumors. Understanding the immune repertoire - the collection of immunological proteins - of treated and untreated cells is possible at the genomic, but technically difficult at the protein level. Standard protein
Seong Won Cha +4 more
core +6 more sources
Antibody Repertoire: Embracing Diversity
Science Translational Medicine, 2011 Adjuvanted formulations expand the vaccine-induced antibody repertoires against a virus and a parasite.
Pollard, A, Hill, A
openaire +4 more sources
Tracing Antibody Repertoire Evolution by Systems Phylogeny [PDF]
Frontiers in Immunology, 2018 Antibody evolution studies have been traditionally limited to either tracing a single clonal lineage (B cells derived from a single V-(D)-J recombination) over time or examining bulk functionality changes (e.g., tracing serum polyclonal antibody proteins)
Alexander Dimitri Yermanos +5 more
doaj +2 more sources
Stability engineering of the human antibody repertoire [PDF]
FEBS Letters, 2013 Human monoclonal antibodies often display limited thermodynamic and colloidal stabilities. This behavior hinders their production, and places limitations on the development of novel formulation conditions and therapeutic applications. Antibodies are highly diverse molecules, with much of the sequence variation observed within variable domain families ...
Rouet, Romain +2 more
openaire +3 more sources
Antibody repertoire and autoimmunity. [PDF]
J Allergy Clin Immunol, 2023 Skevaki C, Wesemann DR.
europepmc +3 more sources
Antibody Repertoire Development in Swine
Annual Review of Animal Biosciences, 2017 We describe the domestication of the species, explore its value to agriculture and bioscience, and compare its immunoglobulin (Ig) genes to those of other vertebrates. For encyclopedic information, we cite earlier reviews and chapters. We provide current gene maps for the heavy and light chain loci and describe their polygeny and polymorphy. B-cell and
Butler, J. E. +2 more
openaire +4 more sources
Structurally Mapping Antibody Repertoires [PDF]
Frontiers in Immunology, 2018 Every human possesses millions of distinct antibodies. It is now possible to analyze this diversity next-generation sequencing of immunoglobulin genes (Ig-seq). This technique produces large volume sequence snapshots of B-cell receptors that are indicative of the antibody repertoire.
Konrad Krawczyk +16 more
openaire +4 more sources
Cell Reports, 2020 Summary: Control of established chronic lymphocytic choriomeningitis virus (LCMV) infection requires the production of neutralizing antibodies, but it remains unknown how the ensemble of antibodies evolves during ongoing infection.
Nike Julia Kräutler +15 more
doaj +1 more source
RAPID: A Rep-Seq Dataset Analysis Platform With an Integrated Antibody Database
Frontiers in Immunology, 2021 The antibody repertoire is a critical component of the adaptive immune system and is believed to reflect an individual’s immune history and current immune status.
Yanfang Zhang +48 more
doaj +1 more source
The VH gene repertoire of splenic B cells and somatic hypermutation in systemic lupus erythematosus [PDF]
, 2003 In systemic lupus erythematosus (SLE) it has been hypothesized that self-reactive B cells arise from virgin B cells that express low-affinity, nonpathogenic germline V genes that are cross-reactive for self and microbial antigens, which convert to high ...
Stott, DI +11 more
core +1 more source