Results 181 to 190 of about 31,703 (224)
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Nature Reviews Nephrology, 2014
IgA nephropathy is defined by the presence of IgA-dominant or co-dominant immune deposits within glomeruli. Biopsy specimens meeting these diagnostic criteria have a range of histological changes that are reflected in the variable clinical course of IgA nephropathy.
Ian S D Roberts, Roberts Ian S D
exaly +3 more sources
IgA nephropathy is defined by the presence of IgA-dominant or co-dominant immune deposits within glomeruli. Biopsy specimens meeting these diagnostic criteria have a range of histological changes that are reflected in the variable clinical course of IgA nephropathy.
Ian S D Roberts, Roberts Ian S D
exaly +3 more sources
Complement activation in IgA nephropathy [PDF]
Seminars in Immunopathology, 2021 IgA nephropathy pathogenesis is incompletely understood, and this limits the development of disease-specific biomarkers and effective therapies. Evidence of complement activity in IgA nephropathy is well established.
Nicholas R Medjeral-Thomas +2 more
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Annual Review of Medicine, 1987
IgA nephropathy is a syndrome and probably the most important glomerular disease in terms of incidence and mortality. This review documents the clinical and pathological features and concentrates on the evolving thoughts regarding pathogenesis and treatment.
A R, Clarkson +4 more
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IgA nephropathy is a syndrome and probably the most important glomerular disease in terms of incidence and mortality. This review documents the clinical and pathological features and concentrates on the evolving thoughts regarding pathogenesis and treatment.
A R, Clarkson +4 more
openaire +2 more sources
Human Pathology, 1977
This presentation attempts to define the criteria for diagnosis of the suggested clinicopathologic entity of IgA nephropathy. Of 250 patients in whom renal biopsies with immunofluorescence, light and electron microscopic, and clinical data were available, 12 patients (4.8 per cent) showed predominance of IgA with localization mainly in the mesangium, a
F, Alexander, A Z, Barabas, R G, Jack
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This presentation attempts to define the criteria for diagnosis of the suggested clinicopathologic entity of IgA nephropathy. Of 250 patients in whom renal biopsies with immunofluorescence, light and electron microscopic, and clinical data were available, 12 patients (4.8 per cent) showed predominance of IgA with localization mainly in the mesangium, a
F, Alexander, A Z, Barabas, R G, Jack
openaire +2 more sources
Current Opinion in Pediatrics, 1999
Immunoglobulin A nephropathy results from the abnormal deposition of IgA immunoglobulin in the glomerulus, which leads to the characteristic presentation of painless hematuria. It is the most common glomerulonephritis worldwide. Originally described 30 years ago, it was thought to follow a benign course.
T E, Hunley, V, Kon
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Immunoglobulin A nephropathy results from the abnormal deposition of IgA immunoglobulin in the glomerulus, which leads to the characteristic presentation of painless hematuria. It is the most common glomerulonephritis worldwide. Originally described 30 years ago, it was thought to follow a benign course.
T E, Hunley, V, Kon
openaire +2 more sources
The microbiome and IgA nephropathy
Seminars in Immunopathology, 2021The immunopathogenic mechanisms underlying immunoglobulin A nephropathy (IgAN) are poorly understood, yet it is one of the most common causes of kidney failure globally. The commonly referenced syndrome of synpharyngitic gross hematuria as a presenting feature of IgAN has led to a logical association between infections and development of IgAN, however ...
Kei Haniuda +2 more
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Seminars in Nephrology, 2008
IgA nephropathy (IgAN) is the most common pattern of primary glomerulonephritis seen in the Western world. In the majority of cases the cause remains unknown. Cases of familial IgAN and secondary IgAN have been reported and these have provided insights into underlying genetic and environmental triggers for this common glomerular disease. Secondary IgAN
Pouria, S, Barratt, J
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IgA nephropathy (IgAN) is the most common pattern of primary glomerulonephritis seen in the Western world. In the majority of cases the cause remains unknown. Cases of familial IgAN and secondary IgAN have been reported and these have provided insights into underlying genetic and environmental triggers for this common glomerular disease. Secondary IgAN
Pouria, S, Barratt, J
openaire +3 more sources
IgA nephropathy and infections
Journal of Nephrology, 2016In this paper we concentrate on the role of infections in IgA nephropathy both from a pathogenetic and clinic point of view. The current hypotheses as regards the role of infections in the pathogenesis of IgA nephropathy are: (a) role of particular pathogens, (b) chronic exposure to mucosal infections, (c) abnormal handling of commensal microbes (gut ...
Cristiana, Rollino +2 more
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Role of IgA in IgA nephropathy
The Journal of Pediatrics, 1990IgA nephropathy (Berger disease) is defined by the dominant or codominant deposition of IgA in the renal mesangium. There is much evidence in vitro to suggest up-regulation of the IgA immune response in patients. Data from tonsillar and bone marrow-derived lymphocytes and from in vivo immunization studies indicate that the primary defect is an up ...
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