Results 91 to 100 of about 185,240 (300)

Assessing the Mucosal Inflammatory Endotype of Obesity in Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory syndrome of the paranasal sinuses that is defined phenotypically as either with nasal polyps (CRSwNP) or without nasal polyps (CRSsNP). More recently, inflammatory markers have been used to cluster patients into putative endotypes that are presumed to have a common ...
Jeffanie W. Gayoso, Li‐Ching Huang, Quanhu Sheng, Daniel Lofgren, Ping Li, Katherine Cahill, Mason Krysinski, Rakesh K. Chandra, Justin H. Turner, Naweed Chowdhury   +9 more
wiley   +1 more source

A Framework for Assessing Ocean Mixed Layer Depth Evolution

Journal of Advances in Modeling Earth Systems
The ocean surface mixed layer plays a crucial role as an entry or exit point for heat, salt, momentum, and nutrients from the surface to the deep ocean.
Alexandre Legay, Bruno Deremble, Thierry Penduff, Pierre Brasseur, Jean‐Marc Molines   +4 more
doaj   +1 more source

Ubiquitous Fungus Irking Inclined Wheezers - A succinct on Allergic Bronchopulmonary Aspergillosis

Journal of Association of Pulmonologist of Tamil Nadu, 2019
Aspergillus mold cause respiratory disease depending upon the host immunity and organism virulence. ABPA is the most significant manifestation of allergic aspergillosis.
Amal Johnson, Vaseema Thabassum, R Narasimhan   +2 more
doaj   +1 more source

IgE and non-IgE-mediated pathways in anaphylaxis

Seminars in Immunopathology
Abstract Anaphylaxis is a severe, potentially life-threatening allergic reaction that can occur through both IgE- and non-IgE-mediated pathways. The classic IgE-mediated pathway involves allergen-specific IgE binding to FcεRI on mast cells and basophils, triggering degranulation and the release of inflammatory mediators.
Margitta Worm, Kristijan Pazur, Payam Morakabati, Davender Redhu   +3 more
openaire   +2 more sources

Effect of heating and glycation on the allergenicity of 2S albumins (Ara h 2/6) from peanut [PDF]

, 2011
Although no effect of processing on T-cell reactivity was observed, heat induced denaturation reduced the IgE reactivity and subsequent functionality of Ara h 2/6.
Mills Clare E. N., Vissers, Yvonne M., Ad P H Jansen, Przybylski-Nicaise Laetitia, Wal, J M, Johnson, P.E., Johnson, PE, Savelkoul, H.F.J., Jansen, A.P.H., Przybylski-Nicaise, L, Adel-Patient Karine, Rigby, NM, Jansen Ad P. H., Blanc, Fany, Ballmer-Weber Barbara, Rigby, Neil M., Yvonne M Vissers, Wal, Jean-Michel, Vissers, Y.M., Wichers Harry J., Alan R. Mackie, Clare E N Mills, Skov, Per Stahl, Mills, Clare E. N., Vissers Yvonne M., Barbara Ballmer-Weber, Zuidmeer-Jongejan Laurian, Clare E. N. Mills, Vissers, Y M, Blanc, F., Szepfalusi, Z., Blanc, F, Laetitia Przybylski-Nicaise, Johnson Phil E., Bernhard, H., Harry J. Wichers, Ballmer-Weber, Barbara, Mills, C E N, Wal Jean-Michel, Skov, P S, Rigby, N M, Per Stahl Skov, Yvonne M. Vissers, Skov, PS, Mackie, A R, Jean-Michel Wal, Ballmer-Weber, B, Rigby, N.M., Johnson, Phil E., Wichers, Harry J., Fany Blanc, Adel-Patient, Karine, Ruinemans-Koerts, J., Mills, E.N.C., Karine Adel-Patient, Jansen, A P H, Vissers, YM, Ruinemans-Koerts, Janneke, Zuidmeer-Jongejan, Laurian, Huub F. J. Savelkoul, Phil E Johnson, Wal, Jean Michel, Savelkoul, HFJ, Stahl Skov, P., Przybylski-Nicaise, Laetitia, L., Adel-Patient, K., Ruinemans-Koerts, J, Wal, J-M, Zuidmeer-Jongejan, L., Rigby Neil M., Jansen, APH, Mackie, A.R., Ad P. H. Jansen, Mackie Alan R., Mackie, Alan R., Jansen, Ad P. H., Wichers, HJ, Johnson, P E, Bernard, Hervé, Wichers, H.J., Przybylski-Nicaise, Laetitia, Blanc Fany, Jansen, Ad P H, Neil M Rigby, Neil M. Rigby, Ballmer-Weber, B., Savelkoul, H F J, Harry J Wichers, Skov Per Stahl, Savelkoul Huub F. J., Szépfalusi, Z, Szépfalusi, Zsolt, Przybylski-Nicaise, L., Wichers, H J, Janneke Ruinemans-Koerts, Savelkoul, Huub F. J., Savelkoul, Huub F J, Bernard, H, Mills, CEN, Hervé Bernard, Alan R Mackie, Zsolt Szépfalusi, Phil E. Johnson, Huub F J Savelkoul, Adel-Patient, K, Szépfalusi Zsolt, Wal, J.M., Bernard Hervé, Ruinemans-Koerts Janneke, Mackie, AR, Laurian Zuidmeer-Jongejan, Wal, Jean-Michel, J.-M., Zuidmeer-Jongejan, L, Mills, Clare E N   +113 more
core   +1 more source

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

Evaluating a virtual paediatric adverse drug reaction clinic

British Journal of Clinical Pharmacology, EarlyView.
Aims Adverse drug reactions (ADRs) are a common problem in paediatric health care. There is limited access to expertise in the evaluation and management of potential ADRs in children, limiting access to these services and creating delays in assessment and management.
Emily Hauck, Blanca Del Pozzo‐Magana, Michael Rieder   +2 more
wiley   +1 more source

Safety and pharmacokinetics of inhaled aloxistatin: A first‐in‐human phase 1 dose escalation trial

British Journal of Clinical Pharmacology, EarlyView.
Aims Aloxistatin (E64d) is a membrane‐permeable cysteine protease inhibitor prodrug that is converted by esterases to the active metabolite E64c (loxistatin). This first‐in‐human study evaluated the safety, tolerability and pharmacokinetics of single ascending doses of inhaled E64d in healthy volunteers.
Sebastian Fähndrich, Franziska Friedrich, Daniel Soriano, Jona Gjeloshi, Björn C. Frye, Xuan Phuoc Nguyen, Lydia Herbstritt, Caroline von Spee‐Mayer, Britta Lang, Fabrice Nollevaux, Andreas Hoheisel, Dorothee Winterberg, Armin Braun, Thomas Epting, Christine Contini, Karl Winkler, Thomas Reinheckel, Franziska C. Trudzinski, Gernot Rohde, Daiana Stolz, Robert Bals, Martin J. Hug, Sebastian Wirtz, Christoph Peters, Carolin Jenkner   +24 more
wiley   +1 more source

Biomarkers in inflammometry pediatric asthma: utility in daily clinical practice

European Clinical Respiratory Journal, 2017
Asthma is a common disease in both high and lower income countries that starts early and persists often for life. A correct and accurate diagnosis, treatment and follow-up during childhood are essential for a better understanding of adult asthma and ...
Silvia Sánchez-García, Alicia Habernau Mena, Santiago Quirce   +2 more
doaj   +1 more source

Evaluation of association of blood and bronchoalveolar eosinophil numbers and serum total immunoglobulin E concentration with the expression of nonspecific airway reactivity in dogs [PDF]

, 1997
To characterize the relation between bronchoalveolar and blood eosinophil numbers, serum total IgE concentration, and nonspecific airway reactivity in healthy ...
Muggenburg, B A, Bice, D E, DeBoer, D J, Collie, D D   +3 more
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