Results 71 to 80 of about 185,240 (300)

Study of immunological parameters associated with asthma with and without bacterial infection in Thi-Qar Province [PDF]

Romanian Journal of Medical Practice
Background. Asthma is a prevalent and persistent respiratory condition that impacts more than 300 million individuals globally, leading to substantial illness and death. Objective.
Huda Kareem ABBAS, Huda Kareem ABBAS
doaj   +1 more source

Identification of IgE as the Allergy-Associated Ig Isotype [PDF]

The Journal of Immunology, 2017
The important role of IgE in the pathogenesis of most allergic disorders makes it appropriate to celebrate the 50th anniversary of its discovery and identification as the allergy-associated Ig isotype and to recall the role of two papers published in The Journal of Immunology on this milestone.
openaire   +2 more sources

CHD8‐Dependent Chromatin Licensing Sustains Trophoblast Stem Cell Transcriptional Programs

Advanced Science, EarlyView.
In this study, Huang et al., identify chromatin remodeler CHD8 as an essential factor in TSC maintenance and placental development. CHD8‐dependent chromatin accessibility supports the occupancy of key trophoblast TFs and is coupled to KMT2A‐associated H3K4me3 deposition at TSC stem and cell cycle genes, providing a permissive chromatin environment for ...
Yuanyuan Huang, Zhenhua Hu, Jiali Liao, Lijun Huang, Jinyu Liu, Chen Tu, Yuchen Li, Lulu Xie, Shilei Bi, Xiaobo Fang, Jingsi Chen, Lili Du, Wei Sun, Haibin Wang, Shuang Zhang, Dunjin Chen, Zhaowei Tu   +16 more
wiley   +1 more source

Total IgE Level in the Peripheral Blood of Patients with Breast Cancer [PDF]

Journal of Mazandaran University of Medical Sciences, 2023
Background and purpose: Breast cancer is one of the most common cancers and the first cause of cancer-related deaths in women. Evidence suggests that allergies may be associated with cancer progression.
Reza Alizadeh-Navaei, Akbar Hedayatizadeh-Omran, Ehsan Zaboli, Mohadeseh Khazaee, Omolbanin Amjadi, Versa Omrani-Nava, Motahareh Kheradmand   +6 more
doaj  

Dual Compartmentalization of GSTA4 Suppresses Ferroptosis to Drive Antiandrogen Resistance in Prostate Cancer

Advanced Science, EarlyView.
The schematic diagram depicts a compartmentalized anti‐ferroptotic defense mechanism mediated by GSTA4. GSTA4 is upregulated and localizes to the cytoplasm in ENZR cells, where it detoxifies 4‐HNE via a non‐canonical GSH‐dependent pathway. Under oxidative stress, GSTA4 translocates to mitochondria, interacts with PGAM5, and blocks Drp1 Ser637 ...
Yong Luo, Wei Zhuang, Zean Li, Yiming Lai, Yongyi Ou, Dongquan Li, Shanhe Huang, Tianlong Luo, Jintao Hu, Bingliang Chen, Jianhan Fu, Tao Zhuo, Hankun Jiang, Yin Lu, Hai Huang, Kewei Xu, Shengmeng Peng, Qing Yuan   +17 more
wiley   +1 more source

Neurometabolite abnormalities and associations with epilepsy duration and cognition in patients with idiopathic generalized epilepsies [PDF]

Epilepsia Open
Abstract Objective This study investigated whether idiopathic generalized epilepsies (IGEs) are associated with neuroinflammation by measuring neurometabolite levels and brain temperature using whole‐brain magnetic resonance spectroscopy imaging (MRSI).
Lien Y, Bankston C, Sharma A, Mitchell B, Nenert R, Moyana A, Pilkington J, Martin R, Morgan C, Ver Hoef L, Szaflarski J, Allendorfer J.   +11 more
europepmc   +2 more sources

Ascaris lumbricoids Infection as a Risk Factor for Asthma and Atopy in Rural Bangladeshi Children. [PDF]

, 2014
Controversy persists as to whether helminth infections cause or protect against asthma and atopy. The aim of this study was to investigate the effects of helminth infection on asthma and atopy among Bangladeshi children.
Persson, Lars Å, Noguchi, Emiko,, Itoh, Makoto,, Noguchi, Emiko, Wagatsuma, Yukiko,, Raqib, Rubhana,, Wagatsuma, Yukiko, Ma, Enbo, Moore, Sophie E; id_orcid, Moore, Sophie E,, Moore, Sophie E, Persson, Lars-Åke,, Raqib, Rubhana, Hawlader, Mohammad D H, Hawlader, Mohammad D H,, Arifeen, Shams E,, Arifeen, Shams E, Ma, Enbo,, Itoh, Makoto, Hawlader, Mohammad DH   +19 more
core   +1 more source

Receptor‐Triggered Peptide Self‐Assembly Enables Multivalent Recruitment of Endogenous Antibodies for Cancer Immunotherapy

Advanced Science, EarlyView.
Receptor‐triggered supramolecular self‐assembly converts monovalent antibody‐recruiting molecules into multivalent platforms directly on cancer cell membranes. The resulting fibrillar assemblies present clustered haptens that efficiently recruit endogenous antibodies, enabling selective complement‐mediated immune killing of EGFR‐positive cancer cells ...
Yihui Wang, Xia Wu, Chenguang Zhao, Hong Han, Wensha Xie, Dan Yuan, Junfeng Shi   +6 more
wiley   +1 more source

Chronic rhinosinusitis and omalizumab: eosinophils not IgE predict treatment response in real-life [PDF]

Rhinology Online, 2018
Background: Chronic rhinosinusitis with and without nasal polyps (CRSwNP and CRSsNP respectively) can be difficult to treat and biologics offer potential as a future therapeutic intervention. CRS and severe asthma often co-exist.
Jagdeep Sahota, Therese Bidder, Rebecca Livingston, Douglas S. Robinson, Valerie J. Lund, Matthew P. Su, Harsha H. Kariyawasam   +6 more
doaj   +1 more source

Tezepelumab in Chinese Patients With Severe Chronic Rhinosinusitis With Nasal Polyps: A Prespecified Subgroup Analysis of the Phase 3 WAYPOINT Trial

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) in Chinese patients often exhibits a mixed Type 1/2/3 inflammatory phenotype (63%), potentially impacting the efficacy of biologics targeting Type 2 inflammation. This prespecified subgroup analysis of WAYPOINT (NCT04851964) evaluated the efficacy and safety of tezepelumab in Chinese
Li Hu, Houyong Li, Xicai Sun, Quan Liu, Yu Xu, Jiangang Fan, Andrew Foster, Claudia Chen, Yun Chon, Dehui Wang   +9 more
wiley   +1 more source