Results 61 to 70 of about 276,806 (364)

AllergoOncology: ultra-low IgE, a potential novel biomarker in cancer—a Position Paper of the European Academy of Allergy and Clinical Immunology (EAACI)

Clinical and Translational Allergy, 2020
Elevated serum IgE levels are associated with allergic disorders, parasitosis and specific immunologic abnormalities. In addition, epidemiological and mechanistic evidence indicates an association between IgE-mediated immune surveillance and protection ...
D. Ferastraoaru, Heather J. Bax, C. Bergmann, Monique Capron, Mariana Castells, David Dombrowicz, E. Fiebiger, Hannah J. Gould, Hannah J. Gould, Karin Hartmann, U. Jappe, G. Jordakieva, D. Josephs, F. Levi‐Schaffer, V. Mahler, Aurélie Poli, D. Rosenstreich, F. Roth‐Walter, M. Shamji, E. Steveling-Klein, M. C. Turner, Eva Untersmayr, S. Karagiannis, S. Karagiannis, Erika Jensen-Jarolim   +24 more
semanticscholar   +1 more source

Effects of geohelminth infection and age on the associations between allergen-specific IgE, skin test reactivity and wheeze: a case-control study. [PDF]

, 2013
BACKGROUND: Most childhood asthma in poor populations in Latin America is not associated with aeroallergen sensitization, an observation that could be explained by the attenuation of atopy by chronic helminth infections or effects of age.
Oviedo, G, Platts-Mills, TA, Vaca, M., Workman, L. J., Platts-Mills, T. A. E., Barreto, M. L., Rodrigues, LC, Moncayo, A-L, Workman, LJ, Vaca, M, Chico, ME, Platts-Mills, TAE, Oviedo, G., Barreto, ML, Moncayo, AL, Rodrigues, L. C., Chico, M. E., Cooper, PJ, Cooper, Philip, Moncayo, A.-L.   +19 more
core   +1 more source

Temporal Changes in Total Serum Immunoglobulin E Levels in East German Children and the Effect of Potential Predictors [PDF]

, 2012
Background: Elevated total serum immunoglobulin E (IgE) levels are a prominent feature of allergic and parasitic diseases. An epidemiologic study was conducted in East German children to describe trends in the development of total serum IgE levels and ...
Wichmann, Heinz-Erich, Rzehak, Peter, Heinrich, Joachim, Wichmann, H.-E., Thiering, Elisabeth, Thiering, E., Brüske, Irene, Rzehak, P., Flohrs, K., Flohrs, Katrin, Heinrich, J., Brüske, I.   +11 more
core   +1 more source

Atopic dermatitis: immune deviation, barrier dysfunction, IgE autoreactivity and new therapies.

Allergology International, 2017
Atopic dermatitis (AD) is a chronic or chronically relapsing, eczematous, severely pruritic skin disorder mostly associated with IgE elevation and skin barrier dysfunction due to decreased filaggrin expression.
M. Furue, T. Chiba, G. Tsuji, D. Ulzii, M. Kido-Nakahara, T. Nakahara, T. Kadono   +6 more
semanticscholar   +1 more source

Anti-IgE therapy for IgE-mediated allergic diseases: from neutralizing IgE antibodies to eliminating IgE+ B cells [PDF]

Clinical and Translational Allergy, 2018
Allergic diseases are inflammatory disorders that involve many types of cells and factors, including allergens, immunoglobulin (Ig)E, mast cells, basophils, cytokines and soluble mediators. Among them, IgE plays a vital role in the development of acute allergic reactions and chronic inflammatory allergic diseases, making its control particularly ...
Jiayun Hu, Jiajie Chen, Lanlan Ye, Zelang Cai, Jinlu Sun, Kunmei Ji   +5 more
openaire   +3 more sources

Association of Gln27Glu Polymorphism of the β2-adrenoreceptor Gene with Specific Parameters of the Immunoregulatory Cytokine Cascade and IgE Production in Patients with Bronchial Asthma

Туберкулез и болезни лёгких, 2022
The objective: to study the level of serum cytokines IL-4, IFN-γ and the activity of IgE production in patients with bronchial asthma (BA) with the consideration of the Gln27Glu-polymorphism of the β2-AR gene.Subjects and Methods.
Kh. I. Turdibekov, E. N. Tashkenbaeva, Sh. Kh. Ziyadullaev, S. Kh. Ibragimov   +3 more
doaj   +1 more source

The Human IgE Repertoire [PDF]

International Archives of Allergy and Immunology, 2013
IgE is a key mediator in allergic diseases. However, in strong contrast to other antibody isotypes, many details of the composition of the human IgE repertoire are poorly defined. The low levels of human IgE in the circulation and the rarity of IgE-producing B cells are important reasons for this lack of knowledge.
Gadermaier, Elisabeth, Levin, Mattias, Flicker, Sabine, Ohlin, Mats   +3 more
openaire   +3 more sources

Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement

Nature Communications, 2018
Acute allergic symptoms are caused by allergen-induced crosslinking of allergen-specific immunoglobulin E (IgE) bound to Fc-epsilon receptors on effector cells.
Jamie M. Orengo, Allen Radin, V. Kamat, A. Badithe, Li-Hong Ben, Brandy L Bennett, S. Zhong, D. Birchard, A. Limnander, A. Rafique, Joannie Bautista, A. Kostić, D. Newell, Xunbao Duan, M. Franklin, William C Olson, Tammy T. Huang, N. Gandhi, A. LipsichLeah, N. Stahl, N. Papadopoulos, Andrew J. Murphy, G. Yancopoulos   +22 more
semanticscholar   +1 more source

The structure of human CD23 and its interactions with IgE and CD21

, 2005
The low-affinity immunoglobulin E ( IgE) receptor, CD23 ( Fc epsilon RII), binds both IgE and CD21 and, through these interactions, regulates the synthesis of IgE, the antibody isotype that mediates the allergic response.
Grundy, GJ, Hibbert, R G, Peter Teriete, Jonathan P. Hannan, Brian J. Sutton, Rajko Reljić, Gould, H J, Rebecca L. Beavil, Holers, V M, Hannah J. Gould, Holers, VM, Richard G. Hibbert, McDonnell, JM, Gabrielle J. Grundy, Hibbert, RG, Sutton, BJ, James M. McDonnell, Reljic, R, V. Michael Holers, Grundy, G J, Gould, HJ, Hannan, JP, Beavil, R L, Sutton, B J, Teriete, P, Beavil, RL, McDonnell, J M; id_orcid, Hannan, J P   +27 more
core   +1 more source

High-affinity allergen-specific human antibodies cloned from single IgE B cell transcriptomes

Science, 2018
IgE B cells unmasked Immunoglobulin E (IgE) antibodies play a central role in immune responses against helminth and protozoan parasites; however, they also contribute to allergies. IgE antibodies (and the B cells generating them) are rare and thus poorly
Derek Croote, S. Darmanis, K. Nadeau, S. Quake   +3 more
semanticscholar   +1 more source