Inhibition of IgE synthesis by anti-IgE: role in long-term inhibition of IgE synthesis by neonatally administered soluble IgE. [PDF]
Inoculation of syngeneic IgE into 2- to 12-day-old mice results in prolonged synthesis of anti-IgE antibodies without further challenge. These anti-IgE antibodies may be largely responsible for the long-term inhibition of synthesis of IgE that is known to result from a perinatal challenge with IgE.
Seiji Haba, Alfred Nisonoff
openaire +3 more sources
Water stable isotope analysis using Cavity Ring-Down Spectroscopy (CRDS) has a strong between-sample memory effect. The classic approach to correct this memory effect is to inject the sample at least 6 times and ignore the first two to three injections ...
Nico Hachgenei+4 more
doaj
Ensemble analysis and forecast of ecosystem indicators in the North Atlantic using ocean colour observations and prior statistics from a stochastic NEMO–PISCES simulator [PDF]
This study is anchored in the H2020 SEAMLESS project (https://www.seamlessproject.org, last access: 29 January 2024), which aims to develop ensemble assimilation methods to be implemented in Copernicus Marine Service monitoring and forecasting systems ...
M. Popov+5 more
doaj +1 more source
Chronic rhinosinusitis and omalizumab: eosinophils not IgE predict treatment response in real-life [PDF]
Background: Chronic rhinosinusitis with and without nasal polyps (CRSwNP and CRSsNP respectively) can be difficult to treat and biologics offer potential as a future therapeutic intervention. CRS and severe asthma often co-exist.
Jagdeep Sahota+6 more
doaj +1 more source
Immune factors preceding diagnosis of glioma: a Prostate Lung Colorectal Ovarian Cancer Screening Trial nested case-control study. [PDF]
BackgroundEpidemiological studies of adult glioma have identified genetic and environmental risk factors, but much remains unclear. The aim of the current study was to evaluate anthropometric, disease-related, and prediagnostic immune-related factors for
Bracci, Paige M+8 more
core
気管支喘息患者における細胞性免疫,ガンジダ抗原に対する遅延型反応の抑制 [PDF]
Delayed cutaneous hypersensitivity towards Candida albicans was examined in 200 patients with bronchial asthma in relation to patient age and the level of total IgE. 1.
Harada, Hideo+7 more
core +1 more source
Molecular and immunological characterization of profilin from mugwort pollen [PDF]
In late summer in Europe, pollen of mugwort is one of the major sources of atopic allergens. No information about the complete molecular structure of any mugwort allergen has been published so far.
Aalbers, M.+9 more
core +2 more sources
Structural basis of omalizumab therapy and omalizumab-mediated IgE exchange
Omalizumab is a widely used therapeutic anti-IgE antibody. Here we report the crystal structure of the omalizumab–Fab in complex with an IgE-Fc fragment. This structure reveals the mechanism of omalizumab-mediated inhibition of IgE interactions with both
L. Pennington+7 more
semanticscholar +1 more source
The effect of lipoprotein-associated phospholipase A2 deficiency on pulmonary allergic responses in Aspergillus fumigatus sensitized mice. [PDF]
BackgroundLipoprotein-associated phospholipase A2 (Lp-PLA2)/platelet-activating factor acetylhydrolase (PAF-AH) has been implicated in the pathogenesis of cardiovascular disease.
Fehrenbach, Melane L+8 more
core +2 more sources