Results 121 to 130 of about 488,312 (382)

Appropriate Medical Therapy Primarily Modifies Type 2 and Severity Biomarkers in Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Appropriate medical therapy (AMT) is first‐line treatment for patients with chronic rhinosinusitis (CRS). We evaluated inflammatory structure, treatment‐induced changes, and biomarker‐outcome associations in AMT‐managed patients. Methods Fifty‐one CRS patients were evaluated before and after AMT which included a combination of oral ...
Asher C. Park, Brooke N. Gleason, Eli Stein, Saied Ghadersohi, Atsushi Kato, Stephanie Shintani‐Smith, David B. Conley, Kevin C. Welch, Robert C. Kern, Bruce K. Tan   +9 more
wiley   +1 more source

Optimizing the dengue virus infection mouse model: Comparing different backgrounds and infection route for enhanced stability

Animal Models and Experimental Medicine, EarlyView.
Optimized dengue fever animal model: IFNAR−/− BALB/c mice with intraperitoneal injection. Background screening: Between IFNAR−/− (BALB/c, C57BL/6) and AG129 mice, IFNAR−/−BALB/c exhibited the most severe symptoms: (1) highest weight loss and clinical scores; (2) peak viremia (5.44 log10 RNA copies/mL, day 4); (3) significant organ damage (liver/brain ...
Dan Liao, Ming Zhong, Wenjiang Zheng, Zhendong Guo, Ye Zhou, Qiuhong Li, Lijuan Qiu, Liangwen Yu, Haishan Long, Geng Li   +9 more
wiley   +1 more source

Low serum IgE as a predictor of impaired polysaccharide vaccine response regardless of IgG concentration [PDF]

, 2020
Matthew Straesser, Monica G. Lawrence, John W. Steinke, Larry Borish   +3 more
openalex   +1 more source

Polydatin alleviates mitochondrial damage and apoptosis of lung epithelial cells by inhibiting toll‐like receptor 4‐dependent macrophage activation in asthma

Animal Models and Experimental Medicine, EarlyView.
The alleviation of asthma by polydatin is dependent on the blockage of the toll‐like receptor 4 (TLR4)/P2X7R synergy in macrophages. The blockage of the TLR4/P2X7R synergy results in decreased release and secretion of interleukin‐1β (IL‐1β) and IL‐18. In epithelial cells, low IL‐1β and IL‐18 levels inhibit mitochondrial damage and apoptosis.
Guangxing Li, Ruobai Liu, Chang Xu, Jianing Yang, Yilan Song, Li Li, Jingzhi Jiang, Liangchang Li, Chongyang Wang, Guanghai Yan   +9 more
wiley   +1 more source

An Investigation of Exercise-Induced Hypoalgesia After Isometric and Cardiovascular Exercise

, 2004
Exercise-induced hypoalgesia is a well-established phenomenon in the literature. The underlying mechanisms responsible for this augmentation of pain perception are not completely understood.
Drury, Daniel G., Miller, James L., Shannon, Robin J., Stuempfle, Kristin J.   +3 more
core  

IgE induces proliferation in human airway smooth muscle cells: role of MAPK and STAT3 pathways [PDF]

, 2013
Airway remodeling is not specifically targeted by current asthma medications, partly owing to the lack of understanding of remodeling mechanisms, altogether posing great challenges in asthma treatment.
Al-Subait, Duaa, Ashdown, Heather L, Gounni, Abdelilah S, Lamkhioued, Bouchaib, Movassagh, Hesam, Redhu, Naresh Singh, Shan, Lianyu   +6 more
core   +2 more sources

The Relationship of IgE Level with Some Biochemical Variables in Iraqi Asthmatic Adult Patients [PDF]

Journal of Bioscience and Applied Research
A chronic respiratory illness known as asthma causes inflammation and airway constriction, which makes breathing difficult. Several metabolic measures may be employed to detect and track asthma.
Khalidah Merzah
doaj   +1 more source

Development of a Sandwich ELISA to Measure Exposure to Occupational Cow Hair Allergens [PDF]

, 2011
Background: Cow hair and dander are important inducers of occupational allergies in cattle-exposed farmers. To estimate allergen exposure in farming environments, a sensitive enzyme immunoassay was developed to measure cow hair allergens.
Angelika Flagge, Anne Spickenheuer, Berger I, Christina Fleischer, Dennis Nowak, Eva Zahradnik, Ferrer A, Heutelbeck AR, Hinze S, Hinze S, Ilka Noss, Ingrid Sander, Joachim Sültz, Krakowiak A, Krop EJ, Lydia Bruckmaier, Monika Raulf-Heimsoth, Noss I, Noss I, Prahl P, Prahl P, Prahl P, Radon K, Rautiainen J, Rautiainen J, Renstrom A, Restani P, Rudolf Schierl, Saarelainen S, Thomas Brüning, Virtanen T, Virtanen T, Virtanen T, Ylonen J, Ylonen J, Ylonen J, Zahradnik E   +36 more
core   +1 more source

Effects of anti‐IL5 biological treatments on blood IgE levels in severe asthmatic patients: A real‐life multicentre study (BIONIGE) [PDF]

, 2022
Marco Contoli, Pierachille Santus, Francesco Menzella, Cindy Rocchi, Dejan Radovanovic, Federico Baraldi, Chiara Martelli, Serena Casanova, Carlo Barbetta, Claudio Micheletto, Nicola Scichilone, Bianca Beghé, Giovanna Elisiana Carpagnano, Alberto Papi   +13 more
openalex   +1 more source

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source