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Annals of Allergy, Asthma & Immunology, 2003
Food allergy (FA) is characterized by an abnormal immunologic reactivity to food proteins. The gastro-intestinal tract serves not only a nutritive function but also is a major immunologic organ. Although previously thought to be triggered primarily by an IgE-mediated mechanism of injury, considerable evidence now suggests that non-IgE mechanisms may ...
Aderbal, Sabra +5 more
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Food allergy (FA) is characterized by an abnormal immunologic reactivity to food proteins. The gastro-intestinal tract serves not only a nutritive function but also is a major immunologic organ. Although previously thought to be triggered primarily by an IgE-mediated mechanism of injury, considerable evidence now suggests that non-IgE mechanisms may ...
Aderbal, Sabra +5 more
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Current Opinion in Immunology, 2001
IgE receptors are implicated as important components of the immunological pathway in allergic and inflammatory diseases. Recent investigations have begun to unravel the structure, signal transduction and function of IgE receptors from different cell types in rodent and human systems.
N, Novak, S, Kraft, T, Bieber
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IgE receptors are implicated as important components of the immunological pathway in allergic and inflammatory diseases. Recent investigations have begun to unravel the structure, signal transduction and function of IgE receptors from different cell types in rodent and human systems.
N, Novak, S, Kraft, T, Bieber
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Biology of IgE Production: IgE Cell Differentiation and the Memory of IgE Responses
2015The generation of long-lived plasma cells and memory B cells producing high-affinity antibodies depends on the maturation of B cell responses in germinal centers. These processes are essential for long-lasting antibody-mediated protection against infections. IgE antibodies are important for defense against parasites and toxins and can also mediate anti-
Jin-Shu, He +5 more
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Current Opinion in Immunology, 1993
Following advances during the past 5 years in our understanding of the molecular structure of receptors for IgE, progress has been made in elucidating the structure and function of IgE receptors and the signalling events through these receptors. IgE is not the only ligand for some of these receptors, leading to their having unexpected and interesting ...
J Y, Bonnefoy +6 more
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Following advances during the past 5 years in our understanding of the molecular structure of receptors for IgE, progress has been made in elucidating the structure and function of IgE receptors and the signalling events through these receptors. IgE is not the only ligand for some of these receptors, leading to their having unexpected and interesting ...
J Y, Bonnefoy +6 more
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IgE-immunotoxins. I. IgE-intact ricin
Immunopharmacology, 1987An IgE immunotoxin consisting of rat IgE myeloma protein, IR 162, conjugated via the heterobifunctional linking agent N-succinimidyl-3-(2-pyridyldithio)propionate to intact ricin was synthesized and evaluated. The capacity of this IgE-immunotoxin to bind to rat basophilic leukemia cells (RBL cells) and to inhibit RBL cell incorporation of [3H]leucine ...
H, Boltansky +3 more
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Cancer Immunology, Immunotherapy, 2011
The nexus of chemotherapeutic intervention and the immunomodulation of IgE-related phenomena are not well understood. The relationship bears importance in better understanding the causal and/or resultant effects of one on the other and their collective role in the management and sequelae of the cancer patient.
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The nexus of chemotherapeutic intervention and the immunomodulation of IgE-related phenomena are not well understood. The relationship bears importance in better understanding the causal and/or resultant effects of one on the other and their collective role in the management and sequelae of the cancer patient.
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IgE-immunotoxins. II. IgE-ricin A-chain
Immunopharmacology, 1987In order to develop a reagent capable of killing cells with high-affinity IgE Fc receptors, such as mast cells and basophils, ricin A-chain (the toxic portion of ricin) was conjugated to rat IgE myeloma protein, IR 162, via derivatization of the IgE by n-succinimidyl-3-(2-pyridyldithio)propionate (SPDP) thus creating an IgE-immunotoxin. Monensin (10(-7)
H, Boltansky +4 more
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Observing the omnipresence of the Ig-fold in all domains of life, one may wonder why this fold among all is such a wunderkind of evolution. Culminating in vertebrates, it enables a myriad of functions at the heart of the immune, nervous, vascular, and muscular systems.
Jiyao, Wang +2 more
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Jiyao, Wang +2 more
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Software: Practice and Experience, 1995
AbstractThis paper describes the problems and complexity of implementing an interpreter for IGES. IGES (the Initial Graphics Exchange Standard) is an attempt to define a language that can specify geometrical, electrical and mechanical specifications with a uniform syntax.The syntax of IGES is sketched first.
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AbstractThis paper describes the problems and complexity of implementing an interpreter for IGES. IGES (the Initial Graphics Exchange Standard) is an attempt to define a language that can specify geometrical, electrical and mechanical specifications with a uniform syntax.The syntax of IGES is sketched first.
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The Importance of IgE and the Uses of Anti-IgE
2020Immunoglobulin E (IgE) is key to the development of allergic disorders, such as allergic asthma. Given this centrality, for many years, manipulation of the elements of the immune system that are linked to IgE function has been a desirable goal in the treatment of asthma and other allergic disorders.
Hakan Güvenir +3 more
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