Results 31 to 40 of about 276,806 (364)
IgE Sialylation is a Determinant of Allergic Pathogenicity
Nature, 2020 Approximately one-third of the world’s population suffers from allergies1. Exposure to allergens crosslinks immunoglobulin E (IgE) antibodies that are bound to mast cells and basophils, triggering the release of inflammatory mediators, including ...
K. Shade +8 more
semanticscholar +1 more source
Journal of Allergy and Clinical Immunology, 2016 Progress in protein chemistry in the 1950s revealed that the biologic activities of proteins, such as hemoglobin and enzymes, are based on partial structures in the protein molecules. This principle suggested to us the possibility that the human antibodies responsible for induction of reaginic hypersensitivity reactions might have unique structures ...
Ishizaka, Kimishige, Ishizaka, Teruko
openaire +2 more sources
IgE and IgG Antibodies as Regulators of Mast Cell and Basophil Functions in Food Allergy
Frontiers in Immunology, 2020 Food allergy is a major health issue, affecting the lives of 8% of U.S. children and their families. There is an urgent need to identify the environmental and endogenous signals that induce and sustain allergic responses to ingested allergens.
C. Kanagaratham +3 more
semanticscholar +1 more source
Origins and clonal convergence of gastrointestinal IgE+ B cells in human peanut allergy
Science immunology, 2020 Peanut-allergic patient GI tissues implicate local IgE class-switching and common IgH genetic rearrangements in pathogenesis. Peanuts in the gut Peanut allergy affects millions of children and adults worldwide, and peripheral blood IgE+ B cells have been
R. Hoh +25 more
semanticscholar +1 more source
Genome-Wide Scan on Total Serum IgE Levels Identifies FCER1A as Novel Susceptibility Locus [PDF]
, 2008 High levels of serum IgE are considered markers of parasite and helminth exposure. In addition, they are associated with allergic disorders, play a key role in anti-tumoral defence, and are crucial mediators of autoimmune diseases.
Wichmann, H. -Erich +126 more
core +1 more source
Geophysical Research Letters, 2023 This study aims to quantify the contribution of anthropogenic forcings on the retreat of the Argentière Glacier (European Alps). The glacier evolution is simulated over 1850–2014 following retrospective scenarios produced with the IPSL‐CM6‐LR climate ...
Léo Clauzel +6 more
doaj +1 more source
LHB Hydroscience Journal, 2023 RÉSUMÉDans le contexte actuel de transition vers un monde plus chaud, le climat d’aujourd’hui n’est déjà plus celui d’hier. Parmi les multiples conséquences de ce réchauffement global, l’intensification des précipitations pourrait entraîner une ...
Guillaume Chagnaud +3 more
doaj +1 more source
Remote Sensing, 2019 The Surface Water and Ocean Topography (SWOT) mission is a next generation satellite mission expected to provide a 2 km-resolution observation of the sea surface height (SSH) on a two-dimensional swath. Processing SWOT data will be challenging because of
Sammy Metref +6 more
doaj +1 more source
Geophysical Research Letters, 2023 Sediment flows generate ground vibrations by exerting force fluctuations on the riverbed. Linking force fluctuations to properties of highly concentrated sediment flows, however, remains particularly challenging due to complexities arising from grain‐to ...
M. Piantini +5 more
doaj +1 more source
Identification of a T follicular helper cell subset that drives anaphylactic IgE
Science, 2019 Thirteen is the charm in anaphylaxis Immunoglobulin E (IgE) is a type of antibody associated with allergies and response to parasites such as worms. When high-affinity, allergen-specific IgE binds its target, it can cross-link receptors on mast cells ...
U. Gowthaman +17 more
semanticscholar +1 more source