High-affinity allergen-specific human antibodies cloned from single IgE B cell transcriptomes
Science, 2018 IgE B cells unmasked Immunoglobulin E (IgE) antibodies play a central role in immune responses against helminth and protozoan parasites; however, they also contribute to allergies. IgE antibodies (and the B cells generating them) are rare and thus poorly
Derek Croote +3 more
semanticscholar +1 more source
The effect of lipoprotein-associated phospholipase A2 deficiency on pulmonary allergic responses in Aspergillus fumigatus sensitized mice. [PDF]
, 2012 BackgroundLipoprotein-associated phospholipase A2 (Lp-PLA2)/platelet-activating factor acetylhydrolase (PAF-AH) has been implicated in the pathogenesis of cardiovascular disease.
Fehrenbach, Melane L +8 more
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IgE-tailpiece associates with α-1-antitrypsin (A1AT) to protect IgE from proteolysis without compromising its ability to interact with FcεRI [PDF]
, 2016 Several splice variants of IgE exist in human plasma, including a variant called IgE-tailpiece (IgE-tp) that differs from classical IgE by the replacement of two carboxy-terminal amino acids with eight novel residues that include an ultimate cysteine. To
Dunne, David W +3 more
core +4 more sources
Molecular and immunological characterization of profilin from mugwort pollen [PDF]
, 2002 In late summer in Europe, pollen of mugwort is one of the major sources of atopic allergens. No information about the complete molecular structure of any mugwort allergen has been published so far.
Aalbers, M. +9 more
core +2 more sources
Differential Gene Expression of Human Mast cell Activation Reveals Gene profiles of Innate and Adaptive Immunity. [PDF]
, 2007 High-density oligonucleotide microarray is a promising approach for high throughput analysis. It has been extensively used in many areas of biomedical research.
Alirio Jose Melendez +3 more
core +2 more sources
Медицинская иммунология, 2022 In view of increased incidence of IgE-mediated diseases in Russia and worldwide, the efforts of various research groups are focused on studying the mechanisms that trigger the process of switching B-lymphocytes to IgE synthesis upon human exposure to ...
D. B. Chudakov +6 more
doaj +1 more source
Respiratory Research, 2018 Bronchial asthma (BA) is a chronic inflammatory disease with a marked heterogeneity in pathophysiology and etiology. The heterogeneity of BA may be related to the inducing mechanism(s) (allergic vs non-allergic), the histopathological background ...
A. Matucci +3 more
semanticscholar +1 more source
Sensitivity of grounding line dynamics to the choice of the friction law
Journal of Glaciology, 2017 Basal slip accounts for a large part of the flow of ice streams draining ice from Antarctica and Greenland into the ocean. Therefore, an appropriate representation of basal slip in ice flow models is a prerequisite for accurate sea level rise projections.
JULIEN BRONDEX +3 more
doaj +1 more source
Effect of β-alanine on humoral immune response in low-dose allergy model
Медицинская иммунология, 2021 At the present time, the efforts of many research groups around the world are aimed at finding new factors triggering the allergic sensitization process linked with IgE synthesis to harmless allergens.
D. B. Chudakov +4 more
doaj +1 more source
Circulating anti-galectin-1 antibodies are associated with the severity of ocular disease in autoimmune and infectious uveitis [PDF]
, 2006 Galectin (Gal)-1, an endogenous lectin found at sites of immune privilege, plays a critical role in the regulation of the immune response. Therapeutic administration of Gal-1 or its genetic delivery suppresses chronic inflammation in experimental models ...
Bianco, German Ariel +6 more
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