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The IGF‐1 receptor in cancer biology
International Journal of Cancer, 2003AbstractThe type 1 insulin‐like growth factor receptor (IGF‐1R) plays an important role in the establishment and maintenance of the transformed phenotype. It also has a strong antiapoptotic activity and has a significant influence on the control of cell and body size. Downregulation of the IGF‐1R leads to massive apoptosis of cancer cells.
Renato, Baserga +2 more
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2001
The so-called somatomedin hypothesis (1) states that growth hormone (GH) acts on skeletal tissues indirectly by inducing the production of a growth factor, somatomedin, circulating in blood and mediating the effects of GH on growth. After the isolation and amino sequencing of insulin-like growth factor I (IGF I) and its biological characterization it ...
Marc Y Donath, Juergen Zapf
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The so-called somatomedin hypothesis (1) states that growth hormone (GH) acts on skeletal tissues indirectly by inducing the production of a growth factor, somatomedin, circulating in blood and mediating the effects of GH on growth. After the isolation and amino sequencing of insulin-like growth factor I (IGF I) and its biological characterization it ...
Marc Y Donath, Juergen Zapf
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GH and IGF-1 Replacement in Children
2019In this chapter, we want to give an overview on what we have learned from more than 30 years ago on the use of recombinant human growth hormone (rhGH) and later recombinant human IGF-1 which was introduced for the treatment of short children and what are the safety issues concerned with this treatment.
Roland, Pfäffle, Wieland, Kiess
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Customizing The Targeting of IGF-1 Receptor
Future Oncology, 2009The type 1 IGF receptor (IGF-IR) is activated by two ligands, IGF-1 and IGF-2, and by insulin at supraphysiological concentrations. It plays a significant role in the growth of normal and abnormal cells, and antibodies against the IGF-IR are now in clinical trials.
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2008
Retinopathy continues to be a major cause of blindness in children (retinopathy of prematurity, ROP), in adults (diabetic retinopathy), and in the elderly (age-related macular degeneration), despite current therapy. Although ablation of the retina reduces the incidence of blindness by suppressing the neovascular phase of ROP and diabetic retinopathy ...
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Retinopathy continues to be a major cause of blindness in children (retinopathy of prematurity, ROP), in adults (diabetic retinopathy), and in the elderly (age-related macular degeneration), despite current therapy. Although ablation of the retina reduces the incidence of blindness by suppressing the neovascular phase of ROP and diabetic retinopathy ...
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Studium interakce inzulinu, IGF-1/2 a analogu IGF-1 s receptory inzulinu a IGF-1
2014Insulin-like growth factors 1 and 2 (IGF-1/2) are single-chain peptides exerting homology (in both amino-acid sequence and tertiary structure) to insulin. The main function of these peptides is promoting celular growth, proliferation and differentiation.
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Insulin-Like Growth Factor-1 (IGF-1) and Its Monitoring in Medical Diagnostic and in Sports
Biomolecules, 2021Julian Bailes +2 more
exaly