Results 111 to 120 of about 30,609,190 (316)

A multi-cohort study of polymorphisms in the GH/IGF axis and physical capability: the HALCyon programme [PDF]

, 2012
Background: Low muscle mass and function have been associated with poorer indicators of physical capability in olderpeople, which are in-turn associated with increased mortality rates.
Kumari, Meena, Hardy, R, John M. Starr (107707), Cooper, R, Gunnell, David, Rachel Cooper, Alfred Tamuno, Alfred, T, Kuh, D., Kumari Meena, Yoav Ben-Shlomo, Tom R Gaunt, Meena Kumari (95278), Kumari, M, Gaunt, Tom R., Cooper Cyrus, Martin, RM, Hardy, R., Team, HS, Sayer Avan Aihie, John M Starr, Day, I.N.M., Ben-Shlomo, Yoav, Ian J. Deary (107724), Tamuno Alfred, Harris, Sarah E, Sayer, AA, Sarah E Harris, Ian N M Day, Ian J Deary, HALCyon Study Team, The HALCyon study team, Gaunt Tom R., Richard M. Martin (176602), Kuh, Diana, Rebecca Hardy (188906), Deary, Ian J, Day, Ian N. M., Martin Richard M., Alfred, Tamuno, Richard M Martin, Yoav Ben-Shlomo (95286), Cooper, C., Diana Kuh, Ben-Shlomo, Y., Starr John M., Deary Ian J., Cooper, C, Martin, R.M., Starr, J.M., Day, IN, Rachel Cooper (188902), David Gunnell, Gaunt, TR, David Gunnell (41947), Harris Sarah E., Kuh Diana, Kumari, M., Gunnell, D, Craig, Leone, Gunnell David, Starr, John M., The HALCyon study team,, Starr, John M, Meena Kumari, Ben-Shlomo, Y, Cyrus Cooper (141250), Cooper, R., Martin, Richard M, Sayer, A.A., Cyrus Cooper, Harris, S.E., Hardy, Rebecca, Starr, JM, Harris, SE, ?, ?, Alfred, T., Avan Aihie Sayer, Cooper, Rachel, Deary, IJ, Gunnell, D., Cooper Rachel, Ian N. M. Day (95288), Avan Aihie Sayer (188916), Rebecca Hardy, Hardy Rebecca, Deary, Ian J., Martin, Richard M., Harris, Sarah E., Day Ian N. M., Cooper, Cyrus, Day, INM, Sayer, Avan Aihie, Tom R. Gaunt (95274), Day, Ian N M, Gaunt, Tom R, Tamuno Alfred (188897), Kuh, D, Gaunt, T.R., Ben-Shlomo Yoav, Sarah E. Harris (107676), Diana Kuh (188923)   +101 more
core   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Insulin and IGF-1 have both overlapping and distinct effects on CD4+ T cell mitochondria, metabolism, and function

Scientific Reports
Insulin and insulin-like growth factor 1 (IGF-1) are metabolic hormones with known effects on CD4+ T cells through insulin receptor (IR) and IGF-1 receptor (IGF-1R) signaling. Here, we describe specific and distinct roles for these hormones and receptors.
Kaitlin Kiernan, Yazan Alwarawrah, Amanda G. Nichols, Keiko Danzaki, Nancie J. MacIver   +4 more
doaj   +1 more source

Determinants of IGF-II influencing stability, receptor binding and activation

Scientific Reports, 2022
Insulin like growth factor II (IGF-II) is involved in metabolic and mitogenic signalling in mammalian cells and plays important roles in normal fetal development and postnatal growth.
Andrew Blyth, Michael Ortiz, Allanah Merriman, Carlie Delaine, Briony Forbes   +4 more
doaj   +1 more source

Bottom‐Up Engineering of a Human Neuromuscular System for Modeling Activity‐Induced Remodeling, Metabolic Stress, and Endothelial‐Modulated Excitability

Advanced Materials, EarlyView.
Using a bottom‐up approach, we engineered a human neuromuscular microchip to investigate distinct adaptive responses to neural stimulation and metabolic stress. Further integration of endothelial cells revealed their critical role in modulating neuromuscular excitability, establishing a comprehensive neurovascular‐muscular model.
Jinchul Ahn, Min‐seop Kim, Ju‐Hee Kim, Seok‐Hyeon Kang, Dain Lee, Hui‐Wen Liu, Seung‐cheol Shin, Kyuhwan Na, Yesl Jun, Oak‐Kee Hong, Ji Hun Yang, Jin‐A Kim, Hwanseok Jang, Hong Nam Kim, Roger D. Kamm, Ji‐Hoon Kim, Jang‐Won Son, Seok Chung   +17 more
wiley   +1 more source

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

Harnessing Large‐Scale Multi‐Omics Data for Risk Prediction and Deep Phenotyping of Valvular Heart Diseases in the General Population

Advanced Science, EarlyView.
Large‐scale UK Biobank analyses identify clinical and proteomic signatures for early prediction of valvular heart disease and its subtypes. Proteins add predictive value for VHD, AVS, and MVR, with outcome‐specific compact panels showing translational potential. Multi‐layer evidence highlights matrix remodeling, protease regulation, immune inflammation,
Zhihao Jiang, Yang Liu, Mingyu Song, Ning Chen, Canqing Yu, Jun Lv, Eric Yuk Fai Wan, Lu Qi, Liming Li, Dianjianyi Sun, Bang Zheng   +10 more
wiley   +1 more source

Gene Correction Enhances Dopaminergic Cell Therapy in a Nonhuman Primate Model of Parkinson's Disease

Advanced Science, EarlyView.
LRRK2‐mutant induced pluripotent stem cells (iPSCs) were derived from a patient with Parkinson's disease (PD). Using CRISPR/Cas9–mediated gene editing, the pathogenic LRRK2 mutations were precisely corrected, and isogenic dopaminergic neural progenitor cells (DA‐NPCs) were subsequently generated.
Qing Yan, Chongchong Xu, Jiangmei Gao, Pu Wang, Qingling Wu, Ying Jin, Binyan Lu, Mu Li, Mingting Shao, Bihai Li, Zhenghui Su, Yijng Zhang, Jianhuan Chen, Haojie An, Mengyao Huang, Xiaoji Zhuang, Yuhui Shen, Fenglin Wang, Nana Xu, Yiyan Liu, Lei Tang, Xiuling Zhong, Minyan Zhong, Jiecong Chen, Zhenhuang Wang, Xingrong Luo, Sheng Liu, RuiFeng Liu, Ling Zhang, Junhua Rao   +29 more
wiley   +1 more source

RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle–Brain Communication

Advanced Science, EarlyView.
A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo, Wei Wu, Huan Peng, Dan He, Yuxi Guo, Boyue Zhao, Xiaodan Wang, Li Ma, Yuhang Qin, Yifang Zhai, Lixia Zhuo, Ying Zhang, Yijie Guo, Linlin Jing, Fangyao Chen, Erfei Zhang, Wei Wang, Xiancang Ma, Yan Li   +18 more
wiley   +1 more source

Spatially Organized Human Ovarian Spheroids Instruct Endometrial Morphogenesis

Advanced Science, EarlyView.
A spatially organized human follicle‐like spheroid (SPHEGaT) composed of granulosa cells (GCs) and stromal‐derived theca‐like cells (TLCs) establishes sustained steroidogenesis in vitro. When co‐cultured with human endometrial organoids (EMOs), estradiol (E2) and progesterone (P4) exchange induces secretory/progesterone‐responsive differentiation ...
Maria João Sousa, Silke De Vriendt, Lixian Liu, Thalles Fernando Rocha Ruiz, Hugo Vankelecom, Christiani Andrade Amorim   +5 more
wiley   +1 more source