Results 271 to 280 of about 152,806 (342)

Single‐Cell RNA‐Seq Reveals Aging‐Related Impairment of Microglial Efferocytosis Contributing to Apoptotic Cells Accumulation After Retinal Injury

Aging Cell, EarlyView.
Microglia engage with apoptotic cells via cell‐surface receptors, such as proto‐oncogene tyrosine‐protein kinase MER (MerTK) and Axl; these receptors interact with the bridging molecule growth arrest‐specific 6 (Gas6) on apoptotic cells. Young microglia demonstrate efficient efferocytosis of apoptotic cells, but this process is impaired in aged ...
Pan Liu, Qi Wang, Shuimiao Wang, Ying Liu, Qiqi Chen, Wanyun Qin, Xinna Liu, Xinqi Ye, Yexuan Jiao, Huiping Yuan, Zhengbo Shao   +10 more
wiley   +1 more source

Unveiling the Role of IGF-I in Fertility: Effect of Long-Acting Bovine Somatotropin (bST) on Terminal Follicular Development and Fertility during an Annual Reproductive Cycle in Sheep. [PDF]

Animals (Basel)
Cox JF, Carrasco A, Navarrete F, Allende R, Saravia F, Dorado J.   +5 more
europepmc   +1 more source

ElixirSeeker: A Machine Learning Framework Utilizing Fusion Molecular Fingerprints for the Discovery of Lifespan‐Extending Compounds

Aging Cell, EarlyView.
ElixirSeeker is a machine learning architecture based on a phenotype‐driven drug discovery approach to screen lifespan‐extending compounds. By integrating molecular fingerprints, ElixirSeeker could maximize feature capture of lifespan‐extending compounds.
Yan Pan, Hongxia Cai, Fang Ye, Wentao Xu, Zhihang Huang, Jingyuan Zhu, Yiwen Gong, Yutong Li, Anastasia Ngozi Ezemaduka, Shan Gao, Shunqi Liu, Guojun Li, Hao Li, Jing Yang, Junyu Ning, Bo Xian   +15 more
wiley   +1 more source

Short‐Term Severe Energy Restriction Promotes Molecular Health and Reverses Aging Signatures in Adults With Prediabetes in the PREVIEW Study

Aging Cell, EarlyView.
Severe short‐term energy restriction in adults with prediabetes led to a significant reduction in circulating proteins linked to inflammation, senescence, and protein turnover. These changes, partly mediated by extracellular vesicles, suggest systemic dietary‐induced benefits beyond glycemic control, including improved aging biomarkers.
Maria Lastra Cagigas, Andrius Masedunskas, Yao Lin, Samantha J. Emery‐Corbin, Jumana M. Yousef, Laura F. Dagley, Sam Olechnowicz, Rory Bowden, Rachael Hayward, Gary Low, Roslyn Muirhead, Jennie Brand‐Miller, Mikael Fogeltholm, Anne Raben, Marco Demaria, Stephen J. Fuller, Luigi Fontana   +16 more
wiley   +1 more source

Correction to: "Loss-of-Function GHSR Variants Are Associated With Short Stature and Low IGF-I".

J Clin Endocrinol Metab
europepmc   +1 more source

A Novel GH Deficient Rat Model Reveals Cross‐Species Insights Into Aging

Aging Cell, EarlyView.
Mouse studies show disrupted GH signaling reduces body size, increases longevity, and improves health. We developed a CRISPR/Cas9 GH‐deficient rat model to address inconsistent rat evidence. GH‐deficient rats mirrored these findings, showing reduced body weight, increased body fat, enhanced insulin sensitivity, and altered gut microbiomes.
Soe Maung Maung Phone Myint, Alexander Tate Lasher, Kaimao Liu, Aron M. Geurts, Steven N. Austad, Liou Y. Sun   +5 more
wiley   +1 more source

IGF-I, bFGF AND TGF-?? IMMUNOREACTIVITIES AFTER ECCENTRIC CONTRACTION-INDUCED MUSCLE INJURY IN VIVO

, 1998
Kei Sakamoto, Kunihiro Sakuma, K. Watanabe, Tsuyoshi Totsuka, Kazunori Nosaka   +4 more
openalex   +1 more source

Avian Lifespan Network Reveals Shared Mechanisms and New Key Players in Animal Longevity

Aging Cell, EarlyView.
In this work, we found that birds with similar lifespans exhibit convergent evolution in specific genes, suggesting that shared evolutionary pressures shape the genetic basis of lifespan similarity across species. By investigating protein–protein interactions across genes evolving convergently in long‐ and short‐lived species, we identified a network ...
Mirko Martini, Giovanni Piccinini, Liliana Milani, Mariangela Iannello   +3 more
wiley   +1 more source