Results 341 to 350 of about 14,093,235 (401)
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The role of insulin receptors and IGF-I receptors in cancer and other diseases
Archives of Physiology and Biochemistry, 2008Francesco Frasca +2 more
exaly +2 more sources
Hormone Research in Paediatrics, 2004
Recent animal studies have demonstrated evidence of the involvement of insulin and insulin-like growth factor (IGF)-I signalling in the control of ageing and longevity. Disruption of insulin/IGF-I signalling pathways significantly extends lifespan in several animal models.
J A M J L, Janssen, S W J, Lamberts
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Recent animal studies have demonstrated evidence of the involvement of insulin and insulin-like growth factor (IGF)-I signalling in the control of ageing and longevity. Disruption of insulin/IGF-I signalling pathways significantly extends lifespan in several animal models.
J A M J L, Janssen, S W J, Lamberts
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Journal of Endocrinology, 1997
Abstract We have previously demonstrated that a specific antiIGF-I antibody will enhance the growth-promoting activity of IGF-I in vivo (Stewart et al. 1993). Since the antibody had a modest affinity for IGF-I we suggested that the antiserum might protect IGF-I from degradation whilst maintaining it in a bioavailable form.
R A, Hill +3 more
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Abstract We have previously demonstrated that a specific antiIGF-I antibody will enhance the growth-promoting activity of IGF-I in vivo (Stewart et al. 1993). Since the antibody had a modest affinity for IGF-I we suggested that the antiserum might protect IGF-I from degradation whilst maintaining it in a bioavailable form.
R A, Hill +3 more
openaire +2 more sources
Current Drug Abuse Reviewse, 2009
It is widely believed that growth hormone (GH) is abused by athletes for its anabolic and lipolytic effects. Many of the physiological effects of GH are mediated by the production of insulin-like growth factor-I (IGF-I). Both GH and IGF-I appear on the World Anti-Doping Agency list of prohibited substances.
Guha, Nishan +5 more
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It is widely believed that growth hormone (GH) is abused by athletes for its anabolic and lipolytic effects. Many of the physiological effects of GH are mediated by the production of insulin-like growth factor-I (IGF-I). Both GH and IGF-I appear on the World Anti-Doping Agency list of prohibited substances.
Guha, Nishan +5 more
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Current Pharmaceutical Design, 2007
The insulin-like growth factor (IGF)-I is implicated in the regulation of protein turnover and exerts potent mitogenic and differentiating effects on most cell types. IGF-I biological actions are mediated by the IGF-I receptor, comprised of two extra-cellular alpha-subunits, containing hormone binding sites, and two membrane-spanning beta-subunits ...
LAVIOLA, Luigi +2 more
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The insulin-like growth factor (IGF)-I is implicated in the regulation of protein turnover and exerts potent mitogenic and differentiating effects on most cell types. IGF-I biological actions are mediated by the IGF-I receptor, comprised of two extra-cellular alpha-subunits, containing hormone binding sites, and two membrane-spanning beta-subunits ...
LAVIOLA, Luigi +2 more
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Molecular and Cellular Endocrinology, 1994
Limited information is available concerning the molecular and cellular mechanisms that regulate expression of insulin-like growth factor-I (IGF-I) binding proteins (IGFBPs) in bovine mammary epithelial cells. Here, we report on the autocrine mechanisms of action of IGF-I and hormonal regulation of expression of IGFBPs in bovine mammary epithelial MD ...
D, Ramagnolo +4 more
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Limited information is available concerning the molecular and cellular mechanisms that regulate expression of insulin-like growth factor-I (IGF-I) binding proteins (IGFBPs) in bovine mammary epithelial cells. Here, we report on the autocrine mechanisms of action of IGF-I and hormonal regulation of expression of IGFBPs in bovine mammary epithelial MD ...
D, Ramagnolo +4 more
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Localization of IGF-I and IGF-I Receptor mRNA inSparus aurataLarvae
General and Comparative Endocrinology, 1997Studies of the ontogeny of IGF-I mRNA during embryonic and larval development of the gilthead sea bream Sparus aurata showed its expression during these early developmental stages. The present study applies in situ hybridization to localize IGF-I and IGF receptor mRNAs in 16-day larvae of S. aurata. Paraffin sections were hybridized with homologous RNA
B, Funkenstein, R, Almuly, S J, Chan
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Clinics in Laboratory Medicine, 2000
Serum IGF-I is controlled by several different regulatory factors. The final adult level represents the sum of the inert circulating depot, newly derived IGF-I synthesized from various tissues including liver, heart, kidney, bone, and others, and the departure from the circulation of IGF-I through mechanisms including receptor internalization and ...
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Serum IGF-I is controlled by several different regulatory factors. The final adult level represents the sum of the inert circulating depot, newly derived IGF-I synthesized from various tissues including liver, heart, kidney, bone, and others, and the departure from the circulation of IGF-I through mechanisms including receptor internalization and ...
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IGF‐I and the IGF‐I receptor in development of nonmammalian vertebrates
Molecular Reproduction and Development, 1993AbstractExtracellular signals are likely to be involved in the control of growth and differentiation during embyrogenesis of vertebrates. These signals include, among others, several members of the insulin family: insulin‐like growth factor (IGF)‐I, IGF‐II, and insulin. In the chick embryo, maternal IGF‐I is stored in the yolk.
F, de Pablo +7 more
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Patient Selection for IGF-I Therapy
Hormone Research, 2006• Many patients previously classified as 'idiopathic short stature' have Primary IGFD. In some studies, this number is as high as 50%. • For patients with severe Primary IGFD, treatment of choice should be IGF-I, either alone or in combination with IGFBP-3.
Clayton, P. E. +2 more
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