Results 361 to 370 of about 14,093,235 (401)

Overview of the IGF-I System

Hormone Research, 2006
• The IGF system is the major mediator of both intra-uterine and postnatal growth. • The IGF-I receptor appears to mediate the growth-promoting effects of both IGF-I and IGF-II. • The role of IGF binding proteins in mediating the growth-promoting actions of the IGFs is complex and remains incompletely understood.
openaire   +2 more sources

Molecular Mechanisms of IGF-I Deficiency

Hormone Research, 2006
• A molecular basis for many forms of Primary IGFD has now been identified. • Disorders of the GH receptor can have low levels of GHBP (as in most defects of the extracellular domain of the GH receptor), or normal levels of GHBP (as in defects of the transmembrane and intracellular domains) • A growth phenotype similar to that seen in defects of the GH
openaire   +2 more sources

IGF-I/IGF-IR signalling

, 2017
E. Kopantsev, E. V. Grankina, M. Kopantseva, E. Sverdlov   +3 more
semanticscholar   +1 more source

IGF-I and IGF-I receptor in mouse colon cancer cells

In Vitro Cellular & Developmental Biology - Animal, 1991
P, Singh, Y S, Guo, S, Narayan, Y, Chandrasekhar   +3 more
openaire   +2 more sources

Age related IGF-I changes and IGF-I generation in thalassemia major.

Pediatric endocrinology reviews : PER, 2011
We measured serum concentrations of insulin like growth factor-I (IGF-I) in 20 thalassemic males with short stature (height SDS
Ashraf T, Soliman, Ahmed, Abushahin, Khalid, Abohezeima, Hany, Khalafallah, Ashraf, Adel, Ahmed, Elawwa, Naima, Elmulla   +6 more
openaire   +1 more source

IGF-I Physiology and Breast Cancer

1998
Recent studies imply that IGF-I levels vary greatly between normal women, and that premenopausal breast cancer risk is increased among women with higher IGF-I levels. It is known that tamoxifen lowers IGF-I levels, but further research is needed to determine whether antiestrogens will be of particular value in risk reduction for women with high IGF-I ...
openaire   +2 more sources

IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1.

American Journal of Physiology. Endocrinology and Metabolism, 2004
J. Sacheck, A. Ohtsuka, S. C. McLary, A. Goldberg   +3 more
semanticscholar   +1 more source

IGF-I

1998
Tak W. Mak, Josef Penninger, John Roder, Janet Rossant, Mary Saunders   +4 more
openaire   +1 more source

IGF-I

Inpharma Weekly, 1991
openaire   +1 more source

GH-IGF-I deficit

2010
La sindrome da difetto di GH (GHD) nell’adulto è un entità clinica riconosciuta solo negli ultimi decenni, quando sono stati dimostrati gli importanti effetti metabolici del GH nell’arco di tutta la vita. Il GH infatti possiede azioni anaboliche sull’osso, sul muscolo scheletrico e cardiaco, mediate prevalentemente dall’IGF-I, promuove sintesi ...
DEGLI UBERTI, Ettore, BONDANELLI, Marta
openaire   +1 more source