Results 71 to 80 of about 231,413 (253)

Expanding Genetic Code to Generate Human Brain Organoids with Both Vasculature and Microglia‐Like Cells

Advanced Science, EarlyView.
Using genetic code expansion, we engineered vascularized human cerebral organoids (vhCOs) with microglia‐like cells and blood‐brain barrier features. vhCOs recapitulate neurovascular interactions, regional identities, and neuronal subtypes resembling the fetal brain.
Haishuang Lin, Yaqing Wang, Hu Du, Yuxin Qin, Haoyu Zhang, Peng Wang, Lin Wei, Jianhua Qin   +7 more
wiley   +1 more source

Synergistic and antagonistic effects of TNF-[alpha] and IGF-I in heart failure : "in vitro" and "in vivo" study of cardiac and skeletal muscle [PDF]

, 2006
Cardiovascular diseases are a major cause of morbidity and mortality in industrialized countries. All forms of myocardial injury first lead to compensatory hypertrophy, which eventually progresses to heart failure.
Murigande, Claire
core   +1 more source

Multi‐Tissue Crosstalk Regulating Meniscus Healing Under Inflammation and Physiological Loading

Advanced Science, EarlyView.
Using a novel Meniscus‐on‐a‐chip (MoC) model integrated with a meniscus‐specific bioreactor, this study investigated the roles of multi‐tissue crosstalk that regulates injury, healing, and degeneration of the meniscus injury under inflammation and pathophysiological loading.
Hun Jin Jeong, Elen Zhu, Min Seo Kang, Ming Wang, Sam Comito, Chang H. Lee   +5 more
wiley   +1 more source

Changes in insulin and IGF-I receptor expression during differentiation of human preadipocytes [PDF]

, 2009
Mature adipocytes originate from fibroblast-like precursor cells, preadipocytes, which differentiate to obtain the characteristics of adipocytes. Our aim was to investigate how differentiation of human preadipocytes affects the distribution of insulin ...
Arnqvist, Hans,, Bäck, Karolina, Bäck, Karolina,, Arnqvist, Hans   +3 more
core   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

Clinic-to-Mechanism: Unraveling in-depth molecular dysfunctions caused by a GluN2B C-Terminal deletion in developmental and epileptic encephalopathies

Translational Psychiatry
Developmental and epileptic encephalopathies (DEEs) are severe neurodevelopmental disorders associated with genetic mutations, including some in GRIN genes encoding NMDA receptor (NMDA-R) subunits.
Roza Szlendak, Nathalie Bouquier, Sylwia Rzońca-Niewczas, Annie Varrault, Tristan Bouschet, Mariola Rudzka-Dybała, Paulina Górka-Skoczylas, Philippe Lory, Dorota Hoffman-Zacharska, Julie Perroy   +9 more
doaj   +1 more source

Sequence, number of amino acids and molecular weight of human IGF-I, three human pro-IGF-I isoforms, full-length MGF, Human MGF, Goldspink-MGF and Long R3-IGF-I (modified from Thevis et al. (6)).

, 2016
Sequence, number of amino acids and molecular weight of human IGF-I, three human pro-IGF-I isoforms, full-length MGF, Human MGF, Goldspink-MGF and Long R3-IGF-I (modified from Thevis et al. (6)).
Joseph A. M. J. L. Janssen (3175791), Christian J. Strasburger (3175785), Elisabeth S. R. van den Dungen (3175788), Mario Thevis (284069), Leo J. Hofland (612920)   +4 more
core   +1 more source

AKT signaling mediates IGF-I survival actions on otic neural progenitors [PDF]

, 2012
Background: Otic neurons and sensory cells derive from common progenitors whose transition into mature cells requires the coordination of cell survival, proliferation and differentiation programmes.
Sanchez-Calderon, Hortensia, Marta Magariños, Leon, Yolanda, Maria R Aburto, Maria R. Aburto (186884), Varela-Nieto, Isabel, Yolanda Leon (5649538), Leon Yolanda, Yolanda Leon, Rodriguez Aburto, Maria, Magariños Marta, Hortensia Sanchez-Calderon, Hortensia Sanchez-Calderon (186893), Isabel Varela-Nieto (186892), Marta Magariños (186888), Aburto Maria R., Isabel Varela-Nieto, Varela-Nieto Isabel, Sanchez-Calderon Hortensia, Magariños, Marta   +19 more
core   +2 more sources

Innovative Approach Reveals How Receptors Control G Protein State Equilibria

Advanced Science, EarlyView.
Using conformational specific trFRET biosensors of the Gi protein (depicted at the bottom), the authors show that receptor activation can not only release GDP from the inactive G protein, but can also release GTP from the activated G protein, leading to the reformation of the RG ternary complex.
Alexandre Bouyssou, Mélanie Da Silva, Julien Soulé, Ludovic Fabre, Laurent Lamarque, Rémy Sounier, Thierry Durroux, Sébastien Granier, Thomas Roux, Elodie Dupuis, Eric Trinquet, Philippe Rondard, Jean‐Philippe Pin   +12 more
wiley   +1 more source

Associations of insulin and insulin-like growth factors with physical performance in old age in the boyd orr and caerphilly studies. [PDF]

, 2012
OBJECTIVE: Insulin and the insulin-like growth factor (IGF) system regulate growth and are involved in determining muscle mass, strength and body composition.
David Gunnell, Gunnell, David, Gallacher, John, Martin, Richard M., Birnie, K, Gunnell, D, Kate Birnie, Gunnell David, Antony Bayer, Bayer Antony, John Gallacher, Ebrahim, S, Holly, Jeff MP, Bayer, A, Yoav Ben-Shlomo, Birnie Kate, Shah Ebrahim, Ben-Shlomo, Y, Ebrahim, Shah, Jeff M P Holly, Gunnell, DJ, Gallacher, J, Martin, Richard M, Holly, JM, Bayer, Antony, Jeff M. P. Holly, Martin Richard M., Martin, RM, Richard M Martin, Richard M. Martin, Holly Jeff M. P., Gallacher John, Holly, JMP, Holly, Jeff M. P., Bayer, Antony James, Birnie, Kate, Ben-Shlomo, Yoav, Ben-Shlomo Yoav, Ebrahim Shah, Gallacher, John Edward   +39 more
core   +2 more sources