Results 51 to 60 of about 231,413 (253)

Anti‐Inflammatory and Neuroactive Effects of Polymer‐Coated Iron Oxide Nanoparticles Functionalized With Interleukin 4 for Spinal Cord Injury

Advanced Healthcare Materials, EarlyView.
Polymer‐coated IONPs functionalized with IL‐4 display respective neuroactive and anti‐inflammatory actions on neural progenitor cells and macrophages/microglia in vitro. When examined chronically in a rat experimental model of spinal cord injury, rGO scaffolds carrying these nanosystems adequately integrate into the lesion, significantly reduce ...
Julia Martínez‐Ramírez, Paloma Lozano‐Picazo, María de Lamo‐Atencia, Andrea Ferreras, Esther Benayas‐Martín, Elena Fernández‐López, Marina Sánchez‐Petidier, Verónica Barranco‐Maresca, Víctor Caz, Anne des Rieux, Juliana M. Rosa, María del Puerto Morales, María C. Serrano   +12 more
wiley   +1 more source

Primary sensory neuron dysfunction underlying mechanical itch hypersensitivity in a Shank3 mouse model of autism

Translational Psychiatry
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder marked by social deficits, repetitive behaviors and atypical sensory perception. The link between ASD and skin abnormalities, inducing itchiness, has never been investigated in depth.
Damien Huzard, Giulia Oliva, Mélanie Marias, Chloé Granat, Vanessa Soubeyre, Glaécia do Nascimento Pereira, Ahmed Negm, Gawain Grellier, Jérôme Devaux, Emmanuel Bourinet, Amaury François   +10 more
doaj   +1 more source

Microgels Enable iPSCs to Assemble, Expand, and Differentiate Into Organoids—From Sizable to High‐Throughput

Advanced Materials, EarlyView.
A chemically defined PEG‐based microgel platform enables scalable, reproducible production of three‐dimensional microgel‐iPSC constructs in multiple sizes. The system is compatible with high‐throughput automation and supports human iPSC expansion and differentiation within a single construct, including directed differentiation into cardiac organoids ...
Laura Klasen, Matthias Mork, Ramin Nasehi, Vasudha Turuvekere Krishnamurthy, Kira Zeevaert, Aaron Babendreyer, Jacopo Di Russo, Wolfgang Wagner, Laura De Laporte   +8 more
wiley   +1 more source

A Critical Review on the Evolution of Chitosan‐Based Injectable Hydrogels in Bone Regeneration

Advanced Materials Interfaces, EarlyView.
The graphical illustration depicts hydrogel formulation using chitosan and biocompatible cross‐linkers, major advantages, and incorporation of cells, osteoinductive factors, and therapeutic drugs. Following injection, pH‐responsive gelation enables controlled drug release, promotes cell recruitment and osteogenic differentiation, enhances extracellular
Shivani Santosh Sakhrani, Abu ul Hassan S. Rana, S. Sudheer Khan   +2 more
wiley   +1 more source

TR-FRET between engineered nanobodies reveals the existence of endogenous CXCR4 oligomers

Communications Biology
Chemokine receptors CXCR4 and ACKR3 are involved in multiple physiological and pathological processes. In overexpression systems, CXCR4 and ACKR3 form oligomers that are important for chemokine recognition and signaling.
Joyce Heuninck, Vladimir Bobkov, Claire M. Grison, Amos Fumagalli, Mathias Lescuyer, Omolade Otun, Cherine Bechara, Laurent Lamarque, Eric Trinquet, Françoise Bachelerie, Philippe Marin, Bernard Mouillac, Sébastien Granier, Bas van der Woning, Hans de Haard, Martine J. Smit, Raimond Heukers, Thierry Durroux   +17 more
doaj   +1 more source

IGF-IIRα regulates IGF-IIR signaling through SIRT1 degradation and HSF1 acetylation.

, 2019
(a) expression levels of IGF-IIR, IGF-IIRα, AT1R, SIRT1, HSF1 and Gαq. Protein expression of cardiac tissue (b) IGF-IIR,(c) IGF-IIRα,(d) AT1R,(e) SIRT1, (f) HSF1 and (g) Gαq.
Pei-Ying Pai (6852617), Ruey-Lin Chang (6852611), Chih-Yang Huang (54970), V. VijayaPadma (6852626), Ray-Jade Chen (795393), Tung-Ti Chang (6852620), Srinivasan Nithiyanantham (6852614), Lai-Chin Hu (6852623), Wei-Wen Kuo (54959)   +8 more
core   +1 more source

Consequences of Postnatally Elevated Insulin-Like Growth Factor-II in Transgenic Mice: Endocrine Changes and Effects on Body and Organ Growth. [PDF]

, 1994
Insulin-like growth factor-II (IGF-II) is an important regulator of embryonic growth and differentiation, but its function in postnatal life is unclear. To address this point, we generated transgenic mice harboring fusion genes in which a human IGF-II
E. Wolf, Eckhard Wolf, Kramer, Rainer, Föll, Jürgen, Gottfried Brem, Brem, Gottfried, Wolf, Eckhard, Jijrgen Fijll, Blum, Werner F., Werner F. Blum, Rainer Kramer   +10 more
core   +2 more sources

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

Annual report IGF 2010 [PDF]

, 2011
Jahresbericht 2010, über die Forschungs- und Lehrtätigkeit des Instituts für Geoinformatik und Fernerkundung ...
Ehlers, Manfred
core   +1 more source

The IGF signaling axis in thyroid cancer: biological complexity and therapeutic challenges

Endocrine Connections
Dysregulation of the insulin-like growth factor (IGF) axis plays an important role in thyroid cancer progression, dedifferentiation, and therapeutic resistance.
Youyun Peng, Shaojie Xu, Hanning Li, Xingrui Li, Yaying Du   +4 more
doaj   +1 more source