Results 41 to 50 of about 231,413 (253)

Expression of the insulin-like growth factor-II/mannose-6-phosphate receptor in multiple human tissues during fetal life and early infancy [PDF]

, 1992
The insulin like growth factor-II/mannose-6-phosphate (IGF-II/M6P) receptor has been detected in many cells and tissues. In the rat, there is a dramatic developmental regulation of IGF-II/M6P receptor expression, the receptor being high in fetal and ...
Eisenmenger, Wolfgang, Kiess, W., Kolb, H. J., Funk, B., Kessler, U., Hansmann, A.   +5 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

A quantitative PCR measurement of messenger RNA expression of IGF-I, IGF-II and IGFBP-5 in human skeletal muscle

, 1999
Insulin-like growth factor-I and -II (IGF-I and IGF-II) and their binding proteins are important components in growth promotion and tissue maintenance.
Sarkar, G, Nair, KS, Coenen, Schimke JM, Conover, CA, Ljungqvist, OH, Coenen Schimke, J. M.,, Sarkar, G.,, Conover, C. A.,, Nair, K. S.,, Ljungqvist, Olle,   +9 more
core   +2 more sources

تأثیر دما بر ساختار فاکتور رشد شبه‌انسولینی (IGF-1) و مطالعه‌ای مبتنی بر شبیه‌سازی با روش‌های دینامیک مولکولی و محاسبات کامپیوتری [PDF]

مجله دانشگاه علوم پزشکی سبزوار, 1970
زمینه و هدف: فاکتور رشد شبه‌انسولینی به‌طور طبیعی در سیستم عصبی مرکزی (CNS) موجود است و نقش مهمی در تکثیر و تمایز سلولی در طی رشد و بلوغ مغز دارد. این فاکتورها به‌همراه پروتئین‌های پیوند به آن‌ها و گیرنده‌هایشان در نواحی آسیب دیده‌ی مغز بیان می‌شوند که ...
ریحانه صباغ زاده
doaj  

Dysregulated Cholesterol Metabolism, Chronic Inflammation, and Disability in Severe Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Dysregulated lipid metabolism, which can affect remyelination and neural repair, has not been extensively investigated in progressive multiple sclerosis (PMS). The goal was to examine whether dysregulated cholesterol metabolism was associated with disability in PMS. Methods The study sample comprised 53 Severe PMS patients (Expanded
Taylor R. Wicks, Mujeeb Shittu, Anna Wolska, Diala Ghazal, Bianca Weinstock‐Guttman, Alexander Burnham, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +8 more
wiley   +1 more source

Acceptance and commitment therapy reduces perceived ostracism in suicidal patients

Annals of General Psychiatry
Introduction Ostracism increases the risk of depression and suicidal behaviors. Mindfulness training, which is at the core of third-wave behavioral therapies such as acceptance and commitment therapy (ACT), might reduce social distress and inhibit ...
Emilie Olié, Manon Malestroit, Véronique Brand-Arpon, Philippe Courtet, Deborah Ducasse   +4 more
doaj   +1 more source

Creatine or guanidinoacetic acid? Which is more effective at enhancing growth, tissue creatine stores, quality of meat, and genes controlling growth/myogenesis in Mulard ducks

Journal of Applied Animal Research, 2019
This study aimed to determine the effectiveness of guanidinoacetic acid (GAA) with or without methionine (Met) compared to creatine (CREA) at enhancing duck’s performance, restoring tissue CREA and improving meat quality.
Doaa Ibrahim, Rania El Sayed, Ahmed Abdelfattah-Hassan, A. M. Morshedy   +3 more
doaj   +1 more source

Self‐Healing Hydrogel‐Enabled Modular Assembly of Bilayered Skin Construct for Hair Follicle Regeneration

Advanced Healthcare Materials, EarlyView.
Self‐healing assembly of two cell‐laden hydrogel layers creates a biomimetic skin construct that restores both dermal and epidermal functions, resulting in accelerated wound healing and enhanced hair follicle regeneration in a full‐thickness skin wound model. ABSTRACT Alopecia remains a pervasive clinical challenge, largely owing to the limited ability
JaeWook Park, Su Yong Kim, MinSu Jeong, Beom Joon Kim, Shin Hyuk Kang, Won‐Gun Koh   +5 more
wiley   +1 more source

Re-expression of IGF-II is important for beta cell regeneration in adult mice [PDF]

, 2012
Background The key factors which support re-expansion of beta cell numbers after injury are largely unknown. Insulin-like growth factor II (IGF-II) plays a critical role in supporting cell division and differentiation during ontogeny but its role in the
Nattkemper, Tim Wilhelm ; https://orcid.org/, Zhou Luxian, Abouna, Sylvie, Julia Herold (136338), James Young (44149), Nattkemper Tim Wilhelm, Abouna Sylvie, Nakhai Hassan, Epstein David, Tim Wilhelm Nattkemper, Herold Julia, Pelengaris Stella, Young, James, Khan, Michael, Stella Pelengaris, Herold, Julia, Nakhai, Hassan, Stella Pelengaris (71018), Hassan Nakhai (136340), Pelengaris, Stella, Sylvie Abouna (71019), Zhou, Luxian, Young James, Luxian Zhou, Michael Khan, Michael Khan (71023), Epstein, David, David Epstein, Luxian Zhou (136331), Hassan Nakhai, Khan Michael, Sylvie Abouna, Epstein, D. B. A., James Young, Nattkemper, Tim W., David Epstein (136335), Tim Wilhelm Nattkemper (136339), Julia Herold   +37 more
core   +2 more sources