Results 41 to 50 of about 224,363 (192)

تأثیر دما بر ساختار فاکتور رشد شبه‌انسولینی (IGF-1) و مطالعه‌ای مبتنی بر شبیه‌سازی با روش‌های دینامیک مولکولی و محاسبات کامپیوتری [PDF]

مجله دانشگاه علوم پزشکی سبزوار, 1970
زمینه و هدف: فاکتور رشد شبه‌انسولینی به‌طور طبیعی در سیستم عصبی مرکزی (CNS) موجود است و نقش مهمی در تکثیر و تمایز سلولی در طی رشد و بلوغ مغز دارد. این فاکتورها به‌همراه پروتئین‌های پیوند به آن‌ها و گیرنده‌هایشان در نواحی آسیب دیده‌ی مغز بیان می‌شوند که ...
ریحانه صباغ زاده
doaj  

Creatine or guanidinoacetic acid? Which is more effective at enhancing growth, tissue creatine stores, quality of meat, and genes controlling growth/myogenesis in Mulard ducks

Journal of Applied Animal Research, 2019
This study aimed to determine the effectiveness of guanidinoacetic acid (GAA) with or without methionine (Met) compared to creatine (CREA) at enhancing duck’s performance, restoring tissue CREA and improving meat quality.
Doaa Ibrahim, Rania El Sayed, Ahmed Abdelfattah-Hassan, A. M. Morshedy   +3 more
doaj   +1 more source

Fluorescent IGF-II analogues for FRET-based investigations into the binding of IGF-II to the IGF-1R

Organic & Biomolecular Chemistry, 2016
Convergent-based synthesis of native IGF-II and two IGF-II analogues, with coumarin fluorescent probes incorporated at residues 19 and 28, and their use in FRET-based identification of interactions with the type 1 insulin-like growth factor receptor (IGF-IR).
Cottam Jones, Jade M, Harris, Paul William Richard, Scanlon, Denis B, Forbes, Briony E, Brimble, Margaret Anne, Abell, Andrew D   +5 more
openaire   +4 more sources

TR-FRET between engineered nanobodies reveals the existence of endogenous CXCR4 oligomers

Communications Biology
Chemokine receptors CXCR4 and ACKR3 are involved in multiple physiological and pathological processes. In overexpression systems, CXCR4 and ACKR3 form oligomers that are important for chemokine recognition and signaling.
Joyce Heuninck, Vladimir Bobkov, Claire M. Grison, Amos Fumagalli, Mathias Lescuyer, Omolade Otun, Cherine Bechara, Laurent Lamarque, Eric Trinquet, Françoise Bachelerie, Philippe Marin, Bernard Mouillac, Sébastien Granier, Bas van der Woning, Hans de Haard, Martine J. Smit, Raimond Heukers, Thierry Durroux   +17 more
doaj   +1 more source

Primary sensory neuron dysfunction underlying mechanical itch hypersensitivity in a Shank3 mouse model of autism

Translational Psychiatry
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder marked by social deficits, repetitive behaviors and atypical sensory perception. The link between ASD and skin abnormalities, inducing itchiness, has never been investigated in depth.
Damien Huzard, Giulia Oliva, Mélanie Marias, Chloé Granat, Vanessa Soubeyre, Glaécia do Nascimento Pereira, Ahmed Negm, Gawain Grellier, Jérôme Devaux, Emmanuel Bourinet, Amaury François   +10 more
doaj   +1 more source

A quantitative PCR measurement of messenger RNA expression of IGF-I, IGF-II and IGFBP-5 in human skeletal muscle

, 1999
Insulin-like growth factor-I and -II (IGF-I and IGF-II) and their binding proteins are important components in growth promotion and tissue maintenance.
Coenen Schimke, J. M.,, Sarkar, G.,, Conover, C. A.,, Nair, K. S.,, Ljungqvist, Olle,   +4 more
core   +2 more sources

Clinic-to-Mechanism: Unraveling in-depth molecular dysfunctions caused by a GluN2B C-Terminal deletion in developmental and epileptic encephalopathies

Translational Psychiatry
Developmental and epileptic encephalopathies (DEEs) are severe neurodevelopmental disorders associated with genetic mutations, including some in GRIN genes encoding NMDA receptor (NMDA-R) subunits.
Roza Szlendak, Nathalie Bouquier, Sylwia Rzońca-Niewczas, Annie Varrault, Tristan Bouschet, Mariola Rudzka-Dybała, Paulina Górka-Skoczylas, Philippe Lory, Dorota Hoffman-Zacharska, Julie Perroy   +9 more
doaj   +1 more source

The IGF signaling axis in thyroid cancer: biological complexity and therapeutic challenges

Endocrine Connections
Dysregulation of the insulin-like growth factor (IGF) axis plays an important role in thyroid cancer progression, dedifferentiation, and therapeutic resistance.
Youyun Peng, Shaojie Xu, Hanning Li, Xingrui Li, Yaying Du   +4 more
doaj   +1 more source

Characteristics of the gravity field of predictive oil-gas areas in the DDD region according to satellite model EGM08 and gravity measurements at the beginning of the XX century

Геофизический журнал, 2019
Gravimetric information is the basis for mineral exploration. The foundations of resource research in Ukraine were started by a large-scale gravimetric survey performed by the Poltava Gravimetric Observatory (PGO) in 1926—1934.
V. G. Bulatsen, L. Ya. Khalyavina, T. E. Borisyuk   +2 more
doaj   +1 more source

Annual report IGF 2010 [PDF]

, 2011
Jahresbericht 2010, über die Forschungs- und Lehrtätigkeit des Instituts für Geoinformatik und Fernerkundung ...
Ehlers, Manfred
core   +1 more source