AIMTOR, a BRET Biosensor for Live Recording of mTOR Activity in Cell Populations and Single Cells
Bio-Protocol, 2021 Mammalian target of rapamycin (mTOR) controls many crucial cellular functions, including protein synthesis, cell size, energy metabolism, lysosome and mitochondria biogenesis, and autophagy.
Nathalie Bouquier +3 more
doaj +1 more source
Insulin-Like Growth Factor (IGF)-I and -11 and IGFBinding Proteins-l, -2, and -3 in Children and Adolescents with Diabetes Mellitus: Correlation with Metabolic Control and Height Attainment. [PDF]
, 1995 The putative effects of diabetes and metabolic control on circulating levels of insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) remain controversial.
Past, Roswitha +6 more
core +1 more source
Translational Oncology, 2021 Progastrin is an unprocessed soluble peptide precursor with a well-described tumor-promoting role in colorectal cancer. It is expressed at small levels in the healthy intestinal mucosa, and its expression is enhanced at early stages of intestinal tumor ...
J. Giraud +15 more
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IGF-I signalling in bone growth: Inhibitory actions of dexamethasone and IL-1 beta [PDF]
, 2007 To determine if glucocorticoids and proinflammatory cytokines inhibit bone growth through a common mechanism involving impaired IGF-I ...
Macrae, V.E. +7 more
core +1 more source
Membranes, 2023 G-protein coupled receptors (GPCRs) are versatile signaling proteins that regulate key physiological processes in response to a wide variety of extracellular stimuli. The last decade has seen a revolution in the structural biology of clinically important
Aurélien Fouillen +4 more
doaj +1 more source
IGF-I and IGF-II in relation to colorectal cancer
International Journal of Cancer, 1999 Recent data suggest that the IGF system plays an important role in the pathogenesis of several forms of human cancer, and there is evidence that IGFs acting in an autocrine and paracrine manner may also affect colorectal cancer risk. We have conducted a case-control study on the island of Crete, Greece, to examine the potential relation between ...
Manousos, O +7 more
openaire +3 more sources
Veterinární Medicína, 2013 Control of metabolic pathways is a major task of the somatotropic axis and its constituents. Insulin-like growth-factor binding proteins (IGFBPs) bind IGF-I and -II and act as carriers and regulators of their activities in blood, body fluids and tissues.
E.C. Kessler +2 more
doaj +1 more source
Synergistic and antagonistic effects of TNF-[alpha] and IGF-I in heart failure : "in vitro" and "in vivo" study of cardiac and skeletal muscle [PDF]
, 2006 Cardiovascular diseases are a major cause of morbidity and mortality in industrialized countries. All forms of myocardial injury first lead to compensatory hypertrophy, which eventually progresses to heart failure.
Murigande, Claire
core +1 more source
Expression of the insulin-like growth factor-II/mannose-6-phosphate receptor in multiple human tissues during fetal life and early infancy [PDF]
, 1992 The insulin like growth factor-II/mannose-6-phosphate (IGF-II/M6P) receptor has been detected in many cells and tissues. In the rat, there is a dramatic developmental regulation of IGF-II/M6P receptor expression, the receptor being high in fetal and ...
Eisenmenger, Wolfgang +5 more
core +1 more source
Acceptance and commitment therapy reduces perceived ostracism in suicidal patients
Annals of General PsychiatryIntroduction Ostracism increases the risk of depression and suicidal behaviors. Mindfulness training, which is at the core of third-wave behavioral therapies such as acceptance and commitment therapy (ACT), might reduce social distress and inhibit ...
Emilie Olié +4 more
doaj +1 more source