Results 61 to 70 of about 48,471 (314)

A Phase II, Randomized, Double-Blind, Placebo-Controlled Study of Simtuzumab in Combination with FOLFIRI for the Second-Line Treatment of Metastatic KRAS Mutant Colorectal Adenocarcinoma. [PDF]

, 2017
Lessons learnedThe safety profile in the patient groups who received FOLFIRI and simtuzumab did not differ from that in the FOLFIRI and placebo group.The addition of simtuzumab to chemotherapy with FOLFIRI does not improve clinical outcomes in patients ...
Bendell, Johanna, Benson, Al B, Hecht, J Randolph, Verma, Udit, Vyushkov, Dmitry, Yang, Yingsi   +5 more
core   +1 more source

Local Specific IgE Levels Can Predict and Monitor the Therapeutic Response to Subcutaneous Immunotherapy With House Dust Mite

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Identifying predictive and monitoring biomarkers for allergen immunotherapy response is crucial for enhancing clinical efficacy. This study aims to investigate the systemic and local levels of immunoglobulins and identify potential biomarkers in house dust mite (HDM) allergic rhinitis (AR) patients who are undergoing subcutaneous ...
Xu Xu, Jingyun Li, Xu Zhang, Yu Song, Lin Xi, Luo Zhang, Yuan Zhang   +6 more
wiley   +1 more source

A Case of IgG4-Related Disease That Mimics an Anterior Mediastinal Malignant Tumour. [PDF]

Respirol Case Rep
We describe a rare case of IgG4‐related disease presenting as an anterior mediastinal mass mimicking malignancy. This case demonstrates the importance of considering IgG4‐related disease in the differential diagnosis of mediastinal tumours, even when FDG‐PET shows abnormal accumulation and serum IgG4 levels are not particularly high.
Nishimura N, Nakamura Y, Yazawa N, Goto Y, Suzuki T, Inoue T, Hasegawa A, Ikeda K, Takemasa A, Chida M, Ishida K, Shimizu Y, Niho S.   +12 more
europepmc   +2 more sources

IgG4-related disease and the current status of diagnostic approaches [PDF]

, 2012
IgG4-related disease is a newly recognized systemic disease characterized by involving a wide range of organs. It includes the pancreas, biliary tree, salivary glands, periorbital tissues, upper aerodigestive tract, retroperitoneum, mediastinum, aorta ...
Du, Haitao, Wan, Jun, Wu, Benyan, Wu, Yinqiao, Yan, Li   +4 more
core  

Endoscopic and clinical evaluation of treatment and prognosis of Cronkhite-Canada syndrome: a Japanese nationwide survey. [PDF]

, 2016
BackgroundFirst reported in 1955, Cronkhite-Canada syndrome (CCS), a rare syndrome characterized by ectodermal abnormalities and inflammatory changes of the gastrointestinal tract mucosa, has been associated with a poor prognosis and life-threatening ...
Hibi, Toshifumi, Hirata, Ichiro, Hokari, Ryota, Kaunitz, Jonathan D, Komoto, Shunsuke, Miura, Soichiro, Tanaka, Masanori, Tomita, Kengo, Watanabe, Chikako   +8 more
core   +1 more source

Serum IgG4 levels at diagnosis can predict unfavorable outcomes of untreated patients with IgG4-related disease [PDF]

, 2021
Ichiro Mizushima, Masahiro Konishi, Hajime Sanada, Kazuyuki Suzuki, Akari Takeji, Takeshi Zoshima, Satoshi Hara, Kiyoaki Ito, Hiroshi Fujii, Kazunori Yamada, Mitsuhiro Kawano   +10 more
openalex   +1 more source

Radiotherapy for parotid IgG4‐related disease

Journal of Medical Radiation Sciences, 2019
We describe the use of radiotherapy for parotid IgG4‐related disease (IgG4‐RD), initially misdiagnosed as Kimura's disease, with sustained good partial response in a 37‐year‐old male.
Daniel E. Roos, Marcus V. Dreosti, Craig L. James, Pravin Hissaria   +3 more
doaj   +1 more source

A subset of ocular adnexal marginal zone lymphomas may arise in association with IgG4-related disease [PDF]

, 2015
We previously suggested a relationship between ocular immunoglobulin (Ig)G4-related disease (IgG4-RD) and marginal zone lymphomas (MZLs). However, the cytokine background associated with these disorders and whether it differs between ocular adnexal MZLs ...
Katsuyoshi, Takata, Koh-ichi, Ohshima, Kyotaro, Ohno, Mai, Takeuchi, Steven, H. Swerdlow, Tadashi, Yoshino, Tomoko, Miyata-Takata, Tomoyasu, Tachibana, Toshihiro, Ito, Yasuharu, Sato, Yorihisa, Orita, Yuka, Gion   +11 more
core   +1 more source

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

IgG4-Related Disease With Gastrointestinal Involvement: Case Reports and Literature Review

Frontiers in Immunology, 2022
IgG4-related disease is an immune-mediated chronic, systemic, and autoinflammatory disease that can affect various organs throughout the body. The most commonly affected areas are the pancreas and biliary system.
Xinhe Zhang, Xing Jin, Lin Guan, Xuyong Lin, Xuedan Li, Yiling Li   +5 more
doaj   +1 more source