Results 71 to 80 of about 66,770 (302)

Selective Targeting of Immune Checkpoints HLA‐G and CD47 Using Novel Dual Signaling Protein DSP216 Promotes Innate Anticancer Immunity

Advanced Science, EarlyView.
The inhibitory immune checkpoints HLA‐G and CD47 are expressed on certain tumor types and inhibit immune cells in the tumor microenvironment. DSP216 binds specifically to cancer cells expressing both HLA‐G and CD47, and blocks their inhibitory signaling.
Lisa J. Jacob, Liat Tamir, Mufeed Abdeen, Ami Tamir, Alexandra Aronin, Itai Bloch, Roy Kahn, Iris Pecker, Mark Tykocinski, Gerwin Huls, Yaron Pereg, Ayelet Chajut, Edwin Bremer   +12 more
wiley   +1 more source

Endoscopic and clinical evaluation of treatment and prognosis of Cronkhite-Canada syndrome: a Japanese nationwide survey. [PDF]

, 2016
BackgroundFirst reported in 1955, Cronkhite-Canada syndrome (CCS), a rare syndrome characterized by ectodermal abnormalities and inflammatory changes of the gastrointestinal tract mucosa, has been associated with a poor prognosis and life-threatening ...
Hibi, Toshifumi, Hirata, Ichiro, Hokari, Ryota, Kaunitz, Jonathan D, Komoto, Shunsuke, Miura, Soichiro, Tanaka, Masanori, Tomita, Kengo, Watanabe, Chikako   +8 more
core   +1 more source

IgG4 levels and plasmablasts as a marker for IgG4-related disease (IgG4-RD) [PDF]

Annals of the Rheumatic Diseases, 2015
Stone and his coworkers present two elegant papers on IgG4-related disease (IgG4-RD).1 In ‘The Diagnostic Utility of Serum IgG4 Concentrations in IgG4-Related Disease’, Carruthers et al 2 retrospectively analysed charts of 190 patients with elevation of IgG4.
Robert I, Fox, Carla M, Fox
openaire   +2 more sources

The future outlook on allergen immunotherapy in children: 2018 and beyond. [PDF]

, 2018
Allergen immunotherapy (AIT) is the only currently available immune-modifying and aetiological treatment for patients suffering from IgE-mediated diseases.
Arasi S, Corsello G, Pajno GB, Villani A
core   +2 more sources

Falsely low IgG4 in routine analysis - How not to miss IgG4 disease [PDF]

, 2016
Background IgG4 disease can have apparently “normal” levels of IgG4 due to antigen excess conditions. IgG4 measurement therefore appears falsely low.
Carruthers, Chari, Deshpande, Ghazale, Hamano, Heidelberger, Jacobs, Jefferis, Kamisawa, Kamisawa, Khosroshahi, Khosroshahi, Lock, Mahajan, Matasubayashi, Morselli-Labate, Neild, Oxelius, Oxelius, Parker, Pieringer, Sadler, Shimosegawa, Umehara, Umehara   +24 more
core   +1 more source

Local Specific IgE Levels Can Predict and Monitor the Therapeutic Response to Subcutaneous Immunotherapy With House Dust Mite

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Identifying predictive and monitoring biomarkers for allergen immunotherapy response is crucial for enhancing clinical efficacy. This study aims to investigate the systemic and local levels of immunoglobulins and identify potential biomarkers in house dust mite (HDM) allergic rhinitis (AR) patients who are undergoing subcutaneous ...
Xu Xu, Jingyun Li, Xu Zhang, Yu Song, Lin Xi, Luo Zhang, Yuan Zhang   +6 more
wiley   +1 more source

IgG4-related disease: patient group characterization and rituximab therapy

Терапевтический архив, 2013
AIM: To characterize a group of patients with IgG4-related disease (IgG4-RD) in a Russian population and to evaluate the efficiency of rituximab therapy/MATERIAL AND METHODS: In 2009 to 2011, at the Research Institute of Rheumatology, Russian Academy of ...
S Kh Sedyshev, V I Vasil'ev, A M Kovrigina, O A Logvinenko, E B Rodionova, T N Safonova, I V Gaĭduk, A Iu Silin, D V Komov, E L Nasonov   +9 more
doaj  

Orbital and Adnexal IgG4-related disease: An insight into the clinical profile and management outcomes

Indian Journal of Ophthalmology
Purpose: IgG4-related disease is a multisystem disorder involving the orbit and adnexa. The purpose of the present study is to report the varied clinical presentations of IgG4-related ophthalmic disease (IgG4 ROD) and their management outcomes.
Prabrisha Banerjee, Md. Shahid Alam, Kirthi Koka, Bipasha Mukherjee, Subramanian Krishnakumar   +4 more
doaj   +1 more source

Specific Antibodies to Recombinant Allergens of \u3cem\u3eAspergillus fumigatus\u3c/em\u3e in Cystic Fibrosis Patients with ABPA [PDF]

, 2006
Background Aspergillus fumigatus, a widely distributed fungus, has been implicated in causing life threatening infections as well as severe asthma and allergic diseases in man.
Bansal, Naveen K., Knutsen, Alan P., Kurup, Viswanath P., Moss, Richard B.   +3 more
core   +1 more source

Interleukin‐5, Eosinophils, and Interleukin‐5 Pathway Inhibitors in Eosinophilic Granulomatosis With Polyangiitis

Arthritis &Rheumatology, EarlyView.
Interlukin‐5 (IL‐5) plays a crucial role in the pathogenesis of eosinophilic granulomatosis with polyangiitis (EGPA) by promoting eosinophil differentiation, activation, and survival. We present here a typical case of EGPA in which treatment with IL‐5 pathway inhibitors is prescribed, showing to be beneficial for the patient.
Alvise Berti, Christian Pagnoux
wiley   +1 more source