Results 121 to 130 of about 427,117 (288)

Atypical Clinical Course of Griscelli Syndrome Type 2 With Primarily Neurologic Presentation and Adult‐Onset in a 46‐Year‐Old Male

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Griscelli Syndrome Type 2 (GS2) is a rare autosomal recessive disorder caused by pathogenic mutations in the RAB27A gene. Typically, it is characterized by cutaneous hypopigmentation, immunodeficiency, with or without neurological abnormalities secondary to hemophagocytic lymphohistiocytosis (HLH). Without treatment, GS2 often results in fatal
Dzhoy Papingi, Michael Kutsche, Helena Lichtenfeld, Fanny Kortüm, Angela Abicht, Laura Herrmann, Theresia Herget   +6 more
wiley   +1 more source

Interaction between the Intergalactic Medium and Galactic Outflows from Dwarf Galaxies

, 1999
We have carried out 2D hydrodynamical simulations in order to study the interaction between supernova-powered gas outflows from low-mass galaxies and the local intergalactic medium (IGM).
Babul, A., Murakami, I.
core   +1 more source

Noonan Syndrome Spectrum Disorders Predispose to Systemic Lupus Erythematosus: Case Report and Critical Review of the Literature

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT RASopathies are clinically overlapping neurodevelopmental syndromes resulting from germline mutations in genes involved in the rat sarcoma/mitogen‐activated protein kinases (RAS/MAPK) pathway. Historically, RASopathies have been described by clinical phenotypes, such as Noonan syndrome and Neurofibromatosis type I.
Anastasia‐Vasiliki Madenidou, Gillian I. Rice, James O'Sullivan, Ben Parker, Ian N. Bruce, Emma Burkitt‐Wright, Tracy A. Briggs   +6 more
wiley   +1 more source

1362 Agonistic 4–1BB IgM antibodies enhance CD8+ T cell proliferation and proinflammatory cytokine secretion in vitro and in vivo

Journal for ImmunoTherapy of Cancer, 2023
Adam Smith, Umesh Muchhal, Dean Ng, Poonam Yakkundi, Gary Bolton, Yuan Cao, Tasnim Kothambawala, Beatrice Wang, Deepal Pandya, Vidhya Bai Krishnoji Rao, Elizabeth Perez, Paul Hinton, Hyewon Phee, Sachi Rahman, Thin Wai, Natalia L dos Santos, Aditya Bharti, Balaji Banoth, Harrison Horwitz, Bruce A Keyt, Angus M Sinclair   +20 more
doaj   +1 more source

Relativistic Pair Beams from TeV Blazars: A Source of Reprocessed GeV Emission rather than IGM Heating

, 2013
The interaction of TeV photons from blazars with the extragalactic background light produces a relativistic beam of electron-positron pairs streaming through the intergalactic medium (IGM). The fate of the beam energy is uncertain.
Giannios, Dimitrios, Sironi, Lorenzo
core   +1 more source

The characteristics of collagen‐induced rheumatoid arthritis in macaques and the changes of heart

Animal Models and Experimental Medicine, EarlyView.
The disease progression in CIA macaques was categorized into three stages: IIR (days 14–34): The indicators related to rheumatoid arthritis and the levels of immunoglobulin were all elevated. There was a small amount of joint effusion, edema and mild synovial hyperplasia. No joint swelling was observed by naked eye.
Lei Zhang, Haifeng Jiang, Zhen Xu, Tingyu Dong, Xiaoyi Liu, Shangxue Yan, Jiajie Kuai, Yan Chang, Wei Wei   +8 more
wiley   +1 more source

Confined B‐Cell Reconstruction and High T‐Cell Clonality Define Clinical Response to Cladribine Treatment

Annals of Neurology, EarlyView.
Cladribine tablets are approved for relapsing multiple sclerosis, mediating their clinical effect by moderately depleting lymphocytes. In a prospective, monocentric study including 22 patients completing 2 annual cycles of cladribine, B‐ and T‐cell receptor repertoires and relapse activity were assessed at baseline and after 24 months. T‐cell clonality
Tilman Schneider‐Hohendorf, Maria Eveslage, Timo Wirth, Christian Wünsch, Eva M. Schumann, Jan D. Lünemann, Heinz Wiendl, Luisa Klotz, Nicholas Schwab   +8 more
wiley   +1 more source

A Multiepitope‐Based Lateral Flow Assay for Leprosy Antibodies

Analysis &Sensing, EarlyView.
An innovative lateral flow assay for leprosy diagnosis is based on gold nanoparticles and synthetic Mycobacterium leprae epitopes conjugated to keyhole limpet hemocyanin protein to enhance antibody detection. This strategy provides a rapid, accurate, and low‐cost approach for resource‐limited settings, enabling the early detection of infection. Leprosy
Cristiane Zocatelli‐Ribeiro, Camila dos Anjos Proença, Ana Carolina da Rosa Nogarolli, Ana Fabiele Domakoski Trevisan, Thiago Neves Machado, João Carlos Degraf Muzzi, Larissa Magalhães Alvarenga, Juliana de Moura   +7 more
wiley   +1 more source

An unusual titanosaur axis from the Upper Cretaceous of Brazil and its significance for sauropod anatomy and systematics

The Anatomical Record, EarlyView.
Abstract The Upper Cretaceous São José do Rio Preto Formation (Bauru Group, southeastern Brazil) has yielded a fragmentary but taxonomically diverse record of titanosaur sauropods, although elements from cervical series remain scarce. Here, we describe a nearly complete sauropod axis from the Vila Ventura Paleontological Area, representing an uncommon ...
Bruno A. Navarro, Jeffrey A. Wilson Mantilla, Jhonata H. A. Martins, Fabiano V. Iori, Leonardo S. Paschoa, Alberto B. Carvalho, Joseli M. Piranha, Hussam Zaher   +7 more
wiley   +1 more source

μRNA E PROGNÓSTICO DO MIELOMA MÚLTIPLO: DADOS DE REVISÃO SISTEMÁTICA

Hematology, Transfusion and Cell Therapy
Objetivo: O presente estudo teve como objetivo realizar uma revisão sistemática visando estimar a influência de μRNAs no prognóstico do Mieloma Múltiplo (MM) e sua correlação com biomarcadores já padronizados ou com biomoléculas já conhecidas na ...
NJ Nazareth, CA Fonseca, MSM Silveira, MS Gonçalves   +3 more
doaj   +1 more source