Results 101 to 110 of about 285,914 (256)

Increased Plasma Microbial tDR‐1 in At‐Risk Individuals Is Associated With Decreased Conversion to Clinical Rheumatoid Arthritis and Reduces an In Vitro Macrophage Type 1 Interferon Response

Arthritis &Rheumatology, EarlyView.
Objective Microbial small RNAs can regulate human genes. Higher plasma concentrations of microbial transfer RNA (tRNA)‐derived RNA‐1 (tDR‐1) were previously associated with lower rheumatoid arthritis (RA) disease activity. This study examined whether tDR‐1 concentrations differ in anticyclic citrullinated peptide‐3 positive (CCP3+) at‐risk individuals (
Anastasiia Phothisane, Tulsi K. Joishy, Carolina Ramirez‐Becerra, Qiong Wu, Jennifer Seifert, Marie L. Feser, Jill M. Norris, M. Kristen Demoruelle, LauraKay Moss, Kevin D. Deane, V. Michael Holers, Michelle J. Ormseth   +11 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Dnmt3a Mutations Limit Normal and Autoreactive CD4+ T Follicular Helper Responses and Attenuate T Cell–Driven Joint Inflammation

Arthritis &Rheumatology, EarlyView.
Objective Somatic DNMT3A mutations are the most common drivers of clonal hematopoiesis in patients with rheumatoid arthritis (RA) and have been associated with seropositive disease and increased markers of inflammation. These mutations are predominantly hypomorphic or dominant‐negative, reducing DNMT3A function.
Yunbing Shen, Sanjaykumar Boddul, Zhaojun Li, Zsolt Kasza, Marlene Schülein, Bruno Raposo, Karine Chemin, Per‐Johan Jakobsson, Alexander Espinosa, Lars Klareskog, Fredrik Wermeling   +10 more
wiley   +1 more source

IgM-mediated autoimmune responses directed against multiple neoepitopes in depression : new pathways that underpin the inflammatory and neuroprogressive pathophysiology

, 2011
IgM-mediated autoimmune responses directed against multiple neoepitopes in depression : new pathways that underpin the inflammatory and neuroprogressive ...
I Mihaylova (13724182), M. Maes (13054533), M Geffard (13330701), M Kubera (13330200), J C Leunis (13330848)   +4 more
core  

1362 Agonistic 4–1BB IgM antibodies enhance CD8+ T cell proliferation and proinflammatory cytokine secretion in vitro and in vivo

Journal for ImmunoTherapy of Cancer, 2023
Adam Smith, Umesh Muchhal, Dean Ng, Poonam Yakkundi, Gary Bolton, Yuan Cao, Tasnim Kothambawala, Beatrice Wang, Deepal Pandya, Vidhya Bai Krishnoji Rao, Elizabeth Perez, Paul Hinton, Hyewon Phee, Sachi Rahman, Thin Wai, Natalia L dos Santos, Aditya Bharti, Balaji Banoth, Harrison Horwitz, Bruce A Keyt, Angus M Sinclair   +20 more
doaj   +1 more source

Oncogenic Alternative Splicing Switches: Role in Cancer Progression and Prospects for Therapy

International Journal of Cell Biology, 2013
Alterations in the abundance or activities of alternative splicing regulators generate alternatively spliced variants that contribute to multiple aspects of tumor establishment, progression and resistance to therapeutic treatments.
Serena Bonomi, Stefania Gallo, Morena Catillo, Daniela Pignataro, Giuseppe Biamonti, Claudia Ghigna   +5 more
doaj   +1 more source

Deep Immunophenotyping Reveals Distinct Immune Signatures in Axial Spondyloarthritis and Psoriatic Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) are overlapping yet distinct conditions within the SpA spectrum. As divergent immunophenotypes may influence disease course and therapeutic response, we compared immune cell subsets, cytokine profiles, and inflammatory mediators.
Natalie Frede, Nils Craig‐Müller, Silke Kohrt, Marei‐Theresa Bott, Ulrich Salzer, Ana Cecilia Venhoff, Jens Thiel, Julia Frede, Reinhard E. Voll, Marta Rizzi, Raquel Lorenzetti, Nils Venhoff   +11 more
wiley   +1 more source

IgM-mediated autoimmune responses to oxidative specific epitopes, but not nitrosylated adducts, are significantly decreased in pregnancy: association with bacterial translocation, perinatal and lifetime major depression and the tryptophan catabolite (TRYCAT) pathway

, 2017
Immunoglubulin (Ig)M responses directed to oxidative specific epitopes (OSEs) and nitric oxide (NO)-adducts are significantly associated with major depression and physio-somatic symptoms.
C Roomruangwong (13330680), AF Carvalho (13973112), B Kanchanatawan (13330695), G Anderson (7719536), S Duleu (13330698), M Geffard (13330701), S Sirivichayakul (13330596), M Maes (13320648)   +7 more
core  

IgM in human immunity to Plasmodium falciparum malaria

, 2019
Most studies on human immunity to malaria have focused on the roles of immunoglobulin G (IgG), whereas the roles of IgM remain undefined. Analyzing multiple human cohorts to assess the dynamics of malaria-specific IgM during experimentally induced and ...
Reiling, L, William, T, Chan, JA, Piera, KA, Oyong, D, Barber, BE, Eisen, DP, Feng, G, Hilton, A, Kurtovic, L, Handayuni, I, Minigo, G, Boyle, MJ, et al., Engwerda, C   +14 more
core   +1 more source

Anti–Carbamylated Fibrinogen Autoantibodies of IgG and IgA Isotypes Contribute to a Better Prognostic Stratification in Very Early Rheumatoid Arthritis: Data From the French National ESPOIR Cohort

Arthritis &Rheumatology, EarlyView.
Objective The aim of this study was to investigate the prevalence and longitudinal evolution of anti–carbamylated fibrinogen antibodies (ACa‐Fib) of IgG and IgA isotypes in early rheumatoid arthritis (RA) and determine whether these antibodies provide additional diagnostic and prognostic information beyond anti–cyclic citrullinated peptide (anti‐CCP ...
Pauline Brevet, Olivia Guérin, Léna Le Goaréguer, Élisa Halbourg, Marie‐Laure Golinski, Sophie Candon, Olivier Boyer, Thierry Lequerré, Thierry Schaeverbeke, Valérie Devauchelle‐Pensec, Olivier Vittecoq, Manuel Fréret   +11 more
wiley   +1 more source