Results 91 to 100 of about 235,216 (254)

Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c+ Basal Cells in Severe Lung Injury

Advanced Science, EarlyView.
In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.
Kaijun Lin, Xinran Deng, Haonan Wang, Yamei Jiang, Jian Sun, Hailin Ding, Ming Ye, Xiaoting Wang, Yu Wang, Li Yuan, Zhenju Song, Xinhua Lin, Shenfei Sun, Ning Jiang   +13 more
wiley   +1 more source

EARLY DETECTION AND EPIDEMIOLOGICAL PROFILE OF OROPOUCHE FEVER IN SALVADOR-BA

Brazilian Journal of Infectious Diseases
Introduction/Objectives: Oropouche fever, caused by the Oropouche virus (OROV), is an arboviral disease with sylvatic and urban cycles endemic to the Amazon region. Transmission occurs through the biting midge Culicoides paraensis. Symptoms include fever,
Adryele Figueiredo Pinheiro, Fernanda Lopes Habib, Marcos Silva Brito, Davi Bastos Lemos, Maria Paula Sampaio, Natalie Nascimento Oliveira, Joilson de Gusmao Guimaraes, Ively Paixão Santos, Gubio Soares Campos, Isadora Cristina de Siqueira   +9 more
doaj   +1 more source

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

P815: HIGH VALENCY OF IGM-2644, A CD38XCD3 IGM BISPECIFIC T CELL ENGAGER, DISPLACES DARATUMUMAB BINDING AND INDUCES POTENT MULTIPLE MYELOMA CELL KILLING

HemaSphere, 2023
Kevin C. Hart, Daniel Santos, Deepal Pandya, Rong Deng, Keyu LI, Yinghui Guan, Genevive Hernandez, Thomas Manley, Maya K. Leabman, Paul R. Hinton, Liqin Liu, Angus M. Sinclair, Albert F. Candia, Stephen F. Carroll, Bruce A. Keyt, Maya F. Kotturi   +15 more
doaj   +1 more source

Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro

Advanced Science, EarlyView.
The presented lymphoid‐tissue‐on‐chip system allows culture of primary human tonsil cells at organotypic high density under perfusion for up to 4 weeks, emulates immune response to soluble vaccines and vaccination via peripheral antigen‐presenting cells and represents a useful tool to assess cellular interactions during homeostasis, immune responses ...
Claudia Teufel, Anna‐Sophie Schlemmer, Andrea W. Eiken, Zachary W. Wagoner, Dennis Vöhringer, Lena Christ, Alex Dulovic, Patrick Marsall, Madeleine Fandrich, Eduardo J. S. Brás, Julia Marzi, Friederike Bärhold, Julia Philipp, Sven Becker, Lisa E. Wagar, Peter Loskill   +15 more
wiley   +1 more source

The Detectability of High Redshift Lyman Alpha Emission Lines Prior to the Reionization of the Universe

, 2002
For a source of Ly alpha radiation embedded in a neutral intergalactic medium (IGM) prior to the reionization epoch, the emission line is strongly suppressed by the intervening IGM. The damping wing of the so-called Gunn-Peterson trough can extend to the
Rhoads J. E., Zoltán Haiman
core   +1 more source

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

Heating the IGM by X-rays from Population III Binaries in High Redshift Galaxies

, 2014
Due to their long mean free path, X-rays are expected to have an important impact on cosmic reionization by heating and ionizing the IGM on large scales, especially after simulations have suggested that Population III stars may form in pairs at redshifts
Ahn, Kyungjin, Norman, Michael L., O'Shea, Brian W., Wise, John H., Xu, Hao   +4 more
core   +1 more source

The Synergism of β‐Cyclodextrin and Fe3+ Enabled Anti‐Swelling Ion‐Conductive Hydrogels for Multimodal Underwater Sensing Aided by Machine Learning Algorithms

Advanced Science, EarlyView.
An anti‐swelling ion‐conductive hydrogel is developed via β‐cyclodextrin and Fe3+ synergism, enabling reliable underwater motion sensing and Morse code communication. Integrated with machine learning, the system achieves 98.6% accuracy in real‐time underwater handwriting recognition for rapid information transmission.
Hao Dong, Chuanliu Liu, Yiming Luo, Dongyu Si, Menghan Zhao, Fangyu Zhao, Yixue Zhang, Wei Zeng, Eman Ramadan Elsharkawy, Terence Xiaoteng Liu, Zeinhom M. El‐Bahy, Hua Hou, Zhanhu Guo, Huige Wei   +13 more
wiley   +1 more source

Hepatocellular carcinoma stem cells: the current state of small molecule-based inhibitors

Cell Death and Disease
Hepatocellular carcinoma (HCC) is the most common type of liver cancer, accounting for over 90% of all cases. Patients with advanced-stage HCC are referred to systemic treatment.
Sara P. Neves, Larissa M. Bomfim, Daniel P. Bezerra   +2 more
doaj   +1 more source