Results 111 to 120 of about 235,216 (254)
Angewandte Chemie, EarlyView.A modular strategy was developed to synthesize tri‐, hexa‐, and nona‐saccharides representing repeating units of the conserved O‐polysaccharide backbone of Salmonella. Conjugates of these glycans to bacteriophage Qβ induced strong IgG responses in mice and rabbits. Antibodies elicited recognized native O‐polysaccharides and conferred protection against
Xingling Pan +7 more
wiley +2 more sources
American Journal of Hematology, EarlyView.ABSTRACT Sutimlimab is a monoclonal antibody against complement fraction C1s approved for the treatment of hemolytic anemia due to cold agglutinin disease (CAD). Here, we analyzed and report the largest international CAD cohort of sutimlimab‐treated patients ever reported to highlight its safety and effectiveness in the real‐world setting. We accrued a
Bruno Fattizzo +38 more
wiley +1 more source
, 2015 The unprecedentedly bright afterglow of Swift GRB 130606A at z = 5.91 gave us a unique opportunity to probe the reionization era by high precision analyses of the redward damping wing of Ly alpha absorption, but the reported constraints on the neutral ...
Aoki, Kentaro +3 more
core +1 more source
Pathogenic PF4/Polyanion ELISA‐Negative Antibodies in HIT
American Journal of Hematology, EarlyView.ABSTRACT Background Platelet factor 4‐polyanion enzyme‐linked immunosorbent assays (ELISAs) are considered highly sensitive for diagnosing heparin‐induced thrombocytopenia (HIT), such that current practice guidelines recommend use of ELISA‐negative results to exclude HIT.
Adam J. Kanack +25 more
wiley +1 more source
, 2012 The Universe is opaque to extragalactic very high-energy gamma rays (VHEGRs, E>100 GeV) because they annihilate and pair produce on the extragalactic background light.
Broderick, Avery E. +2 more
core +1 more source
m.10010T>C Mitochondrial Disease: A Case Report With Hypoparathyroidism and Review of the Literature
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Mitochondria are essential intracellular organelles that play a critical role in cellular metabolism, including the regulation of intracellular calcium signaling. Advances in genomic sequencing have facilitated the identification of rare pathogenic mitochondrial DNA (mtDNA) genetic variants in patients with unexplained endocrine disorders.
Jacob Mohr +5 more
wiley +1 more source
The Opacity of the Intergalactic Medium During Reionization: Resolving Small-Scale Structure
, 2013 Early in the reionization process, the intergalactic medium (IGM) would have been quite inhomogeneous on small scales, due to the low Jeans mass in the neutral IGM and the hierarchical growth of structure in a cold dark matter Universe.
Abel +37 more
core +1 more source
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Griscelli Syndrome Type 2 (GS2) is a rare autosomal recessive disorder caused by pathogenic mutations in the RAB27A gene. Typically, it is characterized by cutaneous hypopigmentation, immunodeficiency, with or without neurological abnormalities secondary to hemophagocytic lymphohistiocytosis (HLH). Without treatment, GS2 often results in fatal
Dzhoy Papingi +6 more
wiley +1 more source
The Low-z Intergalactic Medium. III. HI and Metal Absorbers at z<0.4
, 2008 We conduct an ultraviolet (HST and FUSE) spectroscopic survey of HI (Lyman lines) and seven metal ions (OVI, NV, CIV, CIII, SiIV, SiIII, FeIII) in the low-redshift intergalactic medium (IGM) at ...
Danforth, Charles W., Shull, J. Michael
core +1 more source