Results 121 to 130 of about 235,216 (254)

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

1078 Agonistic CD40 IgM antibodies enhance immune responses beyond that of IgGs

Journal for ImmunoTherapy of Cancer, 2023
Umesh Muchhal, Angus Sinclair, Dean Ng, Bruce Keyt, Sarang Tartey, Vignesh Narayanaswamy, Deepal Pandya, Vidhya Bai Krishnoji Rao, Elizabeth Perez, Paul Hinton, Hyewon Phee   +10 more
doaj   +1 more source

Oncogenic Alternative Splicing Switches: Role in Cancer Progression and Prospects for Therapy

International Journal of Cell Biology, 2013
Alterations in the abundance or activities of alternative splicing regulators generate alternatively spliced variants that contribute to multiple aspects of tumor establishment, progression and resistance to therapeutic treatments.
Serena Bonomi, Stefania Gallo, Morena Catillo, Daniela Pignataro, Giuseppe Biamonti, Claudia Ghigna   +5 more
doaj   +1 more source

The role of IgG avidity in diagnosis of cytomegalovirus infection in newborns and infants [Uloga IgG aviditeta u dijagnostici infekcije citomegalovirusom u novorođenčadi i dojenčadi] [PDF]

, 2012
To evaluate the value of IgG avidity in diagnosis of congenital cytomegalovirus (CMV) infection in newborns and infants we collected serum samples from 40 infants under 12 months of age with suspected congenital CMV infection.
Ljubin-Sternak, Sunčanica, Mlinarić-Galinović, Gordana, Sviben, Mario, Vilibić-Čavlek, Tatjana, Vojnović, Gordana   +4 more
core  

Probing the Intergalactic Medium with Ly$\mathrm{\alpha}$ and 21 cm Fluctuations

, 2017
We study 21cm and Ly$\mathrm{\alpha}$ fluctuations, as well as H$\mathrm{\alpha}$, while distinguishing between Ly$\mathrm{\alpha}$ emission of galactic, diffuse, and scattered intergalactic medium (IGM) origin.
Cooray, Asantha, Feng, Chang, Heneka, Caroline   +2 more
core   +1 more source

USB1 deficiency disrupts neutrophil maturation via RNA dysregulation independent of global pre‐mRNA splicing

Animal Models and Experimental Medicine, EarlyView.
This graphical abstract illustrates the essential role of USB1 in neutrophil maturation. In normal myeloid cells, USB1 acts as an RNA exonuclease, trimming RNA tails to maintain proper RNA network function, which supports the differentiation of myeloid progenitor cells into mature neutrophils.
Hang Li, Guiying Shi, Jiaming Tang, Yiying Huang, Jie Wang, Xuepei Lei, Lin Bai   +6 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Radiative Transfer Effects on the Lya Forest

, 2005
Strong observational evidence for a fluctuating ultraviolet background (UVB) has been accumulating through a number of studies of the HI and HeII Lya forest as well as accurate IGM metallicity measurements.
A. Ferrara, A. Maselli, Abel, Bianchi, Bolton, Bruscoli, Croft, Croft, Fan, Fardal, Fechner, Giallongo, Gnedin, Haardt, Kim, Kriss, Madau, Marri, Maselli, Maselli, McDonald, McDonald, Meiksin, Meiksin, Meiksin, Miniati, Miralda-Escudé, Nakamoto, Navarro, Reimers, Schaye, Shull, Shull, Sokasian, Springel, Steidel, Telfer, Weinberg, Zuo, Zuo   +39 more
core   +2 more sources

Advances and perspectives in animal models of human hepatitis A virus

Animal Models and Experimental Medicine, EarlyView.
Following HAV infection, humans, non‐human primates, and Ifnar1−/− mice develop characteristic manifestations of hepatitis A, including fecal viral shedding, elevated serum ALT levels, and inflammatory cell infiltration in the liver. In contrast, HAV‐infected human liver chimeric mice exhibit fecal viral shedding but do not develop clinical features of
Jian Li, Pei‐Yu Jiang, Hui Zhao, Cheng‐Feng Qin   +3 more
wiley   +1 more source

1362 Agonistic 4–1BB IgM antibodies enhance CD8+ T cell proliferation and proinflammatory cytokine secretion in vitro and in vivo

Journal for ImmunoTherapy of Cancer, 2023
Adam Smith, Umesh Muchhal, Dean Ng, Poonam Yakkundi, Gary Bolton, Yuan Cao, Tasnim Kothambawala, Beatrice Wang, Deepal Pandya, Vidhya Bai Krishnoji Rao, Elizabeth Perez, Paul Hinton, Hyewon Phee, Sachi Rahman, Thin Wai, Natalia L dos Santos, Aditya Bharti, Balaji Banoth, Harrison Horwitz, Bruce A Keyt, Angus M Sinclair   +20 more
doaj   +1 more source