Results 131 to 140 of about 457,033 (338)

Precise Construction of an Antimicrobial Peptide Targeting Bacterial Cell Membranes Derived From Natural Peptides

open access: yesAdvanced Science, EarlyView.
An AMP (P 3‐3R‐8I) based on natural peptides, which can target bacterial cell membranes, was precisely constructed via amino acid mutation. P 3‐3R‐8I exhibits antibacterial capability which could be attributed to the ability of P 3‐3R‐8I to quickly penetrate bacterial cell membranes and then to bind to bacterial DNA.
Jiaqi Huang   +11 more
wiley   +1 more source

Relativistic Pair Beams from TeV Blazars: A Source of Reprocessed GeV Emission rather than IGM Heating

open access: yes, 2013
The interaction of TeV photons from blazars with the extragalactic background light produces a relativistic beam of electron-positron pairs streaming through the intergalactic medium (IGM). The fate of the beam energy is uncertain.
Giannios, Dimitrios, Sironi, Lorenzo
core   +1 more source

A Reactive Antagonist Strategy: Cysteine‐Directed Covalent Molecular Glue in Plant Hormone Receptor Regulation

open access: yesAdvanced Science, EarlyView.
The plant hormone jasmonate is perceived by COI1‐JAZ co‐receptors comprising a single F‐box protein COI1 and multiple JAZ repressors with overlapping functions, complicating genetic analysis. We present a reactive antagonist (RA) strategy that selectively promotes COI1 binding to a cysteine‐engineered JAZ variant while blocking wild‐type JAZs, enabling
Minoru Ueda   +10 more
wiley   +1 more source

1362 Agonistic 4–1BB IgM antibodies enhance CD8+ T cell proliferation and proinflammatory cytokine secretion in vitro and in vivo

open access: yesJournal for ImmunoTherapy of Cancer, 2023
Adam Smith   +20 more
doaj   +1 more source

Clinical evaluation of Graves‘ disease using TSH receptor autoantibody (TRAb)-isotype and TRAb-IgM/TRAb-IgG (the MG ratio)

open access: diamond, 2023
Keiko Nagata   +6 more
openalex   +2 more sources

The Low-z Intergalactic Medium. III. HI and Metal Absorbers at z<0.4

open access: yes, 2008
We conduct an ultraviolet (HST and FUSE) spectroscopic survey of HI (Lyman lines) and seven metal ions (OVI, NV, CIV, CIII, SiIV, SiIII, FeIII) in the low-redshift intergalactic medium (IGM) at ...
Danforth, Charles W., Shull, J. Michael
core   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

open access: yesAdvanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang   +2 more
wiley   +1 more source

Radiative Transfer Effects on the Lya Forest

open access: yes, 2005
Strong observational evidence for a fluctuating ultraviolet background (UVB) has been accumulating through a number of studies of the HI and HeII Lya forest as well as accurate IGM metallicity measurements.
A. Ferrara   +39 more
core   +2 more sources

Interconnected Hierarchically Porous Graphene‐Based Membrane Electrode for High‐Power and Long‐Cycle Lithium–Oxygen Battery

open access: yesAdvanced Science, EarlyView.
Lithium–oxygen batteries face an energy‐power trade‐off due to sluggish O2 transport and pore clogging by Li2O2. Simulations show that reducing tortuosity via interconnected macropores enhances oxygen mobility. A freestanding graphene electrode having interconnected macropores with low tortuosity delivers >2500 mAh g−1, stable lean‐electrolyte cycling,
Arghya Dutta   +7 more
wiley   +1 more source

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