Results 61 to 70 of about 737 (163)

Data‐Driven Molecular Typing: A New Frontier in Esophageal Cancer Management

Cancer Medicine, Volume 14, Issue 5, March 2025.
ABSTRACT Background Esophageal squamous cell carcinoma (ESCC) is a predominant and highly lethal form of esophageal cancer, with a five‐year survival rate below 20%. Despite advancements, most patients are diagnosed at advanced stages, limiting effective treatment options.
Yue Du, Bianli Gu, Linlin Shi, Yong She, Qi Zhao, Shegan Gao   +5 more
wiley   +1 more source

Association between ELP4 rs986527 polymorphism and the occurrence and development of intracranial arachnoid cyst

Brain and Behavior, Volume 9, Issue 12, December 2019., 2019
Intracranial arachnoid cysts with a high prevalence. In this paper, we investigated the association between elongator protein complex 4 (ELP4) rs986527 polymorphism and the occurrence and development of intracranial arachnoid cysts. Abstract Objective The association between ELP4 rs986527 polymorphism and the occurrence and development of intracranial ...
Kai Li, De‐Sheng Kong, Jun Zhang, Xin‐Sheng Wang, Xun Ye, Yuan‐Li Zhao   +5 more
wiley   +1 more source

Phosphatidylserine Ameliorates Neurodegenerative Symptoms and Enhances Axonal Transport in a Mouse Model of Familial Dysautonomia. [PDF]

PLoS Genetics, 2016
Familial Dysautonomia (FD) is a neurodegenerative disease in which aberrant tissue-specific splicing of IKBKAP exon 20 leads to reduction of IKAP protein levels in neuronal tissues. Here we generated a conditional knockout (CKO) mouse in which exon 20 of
Shiran Naftelberg, Ziv Abramovitch, Shani Gluska, Sivan Yannai, Yuvraj Joshi, Maya Donyo, Keren Ben-Yaakov, Tal Gradus, Jonathan Zonszain, Chen Farhy, Ruth Ashery-Padan, Eran Perlson, Gil Ast   +12 more
doaj   +1 more source

Generation of Cholinergic and Dopaminergic Interneurons from Human Pluripotent Stem Cells as a Relevant Tool for In Vitro Modeling of Neurological Disorders Pathology and Therapy

Stem Cells International, Volume 2016, Issue 1, 2016., 2016
The cellular and molecular bases of neurological diseases have been studied for decades; however, the underlying mechanisms are not yet fully elucidated. Compared with other disorders, diseases of the nervous system have been very difficult to study mainly due to the inaccessibility of the human brain and live neurons in vivo or in vitro and ...
Anna Ochalek, Karolina Szczesna, Paolo Petazzi, Julianna Kobolak, Andras Dinnyes, Yang D. Teng   +5 more
wiley   +1 more source

IKAP expression in the developing PNS.

, 2014
(A) QRT-PCR analysis of expression levels of ikbkap, neural specific βIII-Tubulin (TUBB3), β-Actin (ACTB), Islet-1 (ISL1), Retinoic Acid receptor β (RARB), and CACNA1B in developing lumbar DRG of E6-E18 embryos.
Miguel Weil (222465), Anastasia Abashidze (663634), Yaron Anavi (663636), Hayit Greenspan (663637), Veronica Gold (663635)   +4 more
core   +1 more source

Immunoglobulin class‐switch recombination: Mechanism, regulation, and related diseases

MedComm, Volume 5, Issue 8, August 2024.
CSR switches IgM to other immunoglobulins. Following immune response or infection within the body, activation of T cell‐dependent and T cell‐independent antigens triggers the activation of AID, initiating the CSR process. CSR has the capacity to modify the functional properties of antibodies, thereby contributing to the adaptive immune response in the ...
Jia‐Chen Liu, Ke Zhang, Xu Zhang, Fei Guan, Hu Zeng, Masato Kubo, Pamela Lee, Fabio Candotti, Louisa Katherine James, Niels Olsen Saraiva Camara, Kamel Benlagha, Jia‐Hui Lei, Huamei Forsman, Lu Yang, Wei Xiao, Zheng Liu, Chao‐Hong Liu   +16 more
wiley   +1 more source

The Effect of Complementary and Alternative Medicine on Subfertile Women with In Vitro Fertilization

Evidence-Based Complementary and Alternative Medicine, Volume 2014, Issue 1, 2014., 2014
About 10–15% of couples have difficulty conceiving at some point in their reproductive lives and thus have to seek specialist fertility care. One of the most commonly used treatment options is in vitro fertilization (IVF) and its related expansions. Despite many recent technological advances, the average IVF live birth rate per single initiated cycle ...
Yuehui Zhang, Yiman Fu, Fengjuan Han, Hongying Kuang, Min Hu, Xiaoke Wu, Ernest Hung Yu Ng   +6 more
wiley   +1 more source

Inferring kinase activity from phosphoproteomic data: Tool comparison and recent applications

Mass Spectrometry Reviews, Volume 43, Issue 4, Page 725-751, July/August 2024.
Abstract Aberrant cellular signaling pathways are a hallmark of cancer and other diseases. One of the most important signaling mechanisms involves protein phosphorylation/dephosphorylation. Protein phosphorylation is catalyzed by protein kinases, and over 530 protein kinases have been identified in the human genome.
Sander R. Piersma, Andrea Valles‐Marti, Frank Rolfs, Thang V. Pham, Alex A. Henneman, Connie R. Jiménez   +5 more
wiley   +1 more source

The impact of nursing based on the IKAP model on self-management and psychological well-being in prostate cancer patients: a retrospective study [PDF]

Journal of Men's Health
Background: This study aims to evaluate the impact of the model of information-knowledge-attitude-practice (IKAP) nursing model on the self-management and psychological well-being in patients diagnosed with prostate cancer. Methods: From existing case
Feilei Li, Binyu Zhou, Hui Yu, Shengtao Liu, Hezhen Ye   +4 more
doaj   +1 more source

Phosphatidylserine and pridopidine increase IKAP levels in FD cells through the same mechanism.

, 2019
(A) FD cells were treated either with 50 μg/ml of PS or 500 nM of pridopidine or the combination of both drugs. Proteins were extracted and analyzed after 7 days. Left panel: Western blot of extracted proteins analyzed using anti-IKAP antibody.
Maya Donyo (234098), Sivan Yannai (3594626), Jonathan Zonszain (3594617), Gil Ast (10995)   +3 more
core   +1 more source