Results 71 to 80 of about 737 (163)

Phosphatidylserine improves axonal transport by inhibition of HDAC and has potential in treatment of neurodegenerative diseases

Neural Regeneration Research, 2017
Familial dysautonomia (FD) is a rare children neurodegenerative disease caused due to a point mutation in the IKBKAP gene that results in decreased IKK complex-associated protein (IKAP) protein production.
Shiran Naftelberg, Gil Ast, Eran Perlson
doaj   +1 more source

Sensorimotor control in the congenital absence of functional muscle spindles

Experimental Physiology, Volume 109, Issue 1, Page 27-34, 1 January 2024.
Abstract Hereditary sensory and autonomic neuropathy type III (HSAN III), also known as familial dysautonomia or Riley–Day syndrome, results from an autosomal recessive genetic mutation that causes a selective loss of specific sensory neurones, leading to greatly elevated pain and temperature thresholds, poor proprioception, marked ataxia and ...
Vaughan G. Macefield, Lyndon J. Smith, Lucy Norcliffe‐Kaufmann, Jose‐Alberto Palma, Horacio Kaufmann   +4 more
wiley   +1 more source

IKAP protein levels are highly reduced in FD mutant mice and after lentiviral ShIKAP administration in Oli-neu cells.

, 2014
(A) Western blot analyses of total protein lysates from brain cortex of control (N1, N2, N3) and age-matched FD (FD1, FD2, FD3) littermates. Upper panel shows detection of IKAP with the polyclonal anti-IKAP antibody (AnaSpec), and lower panel shows anti ...
Paula Dietrich (340949), Miguel Weil (222465), Channa Maayan (234102), David Cheishvili (554749), Aviel Even (554750), Ioannis Dragatsis (340951), Aharon Razin (554751)   +6 more
core   +1 more source

KAJIAN PENGEMBANGAN KAPAL WISATA BERBASIS ENERGI ALTERNATIF: KOMBINASI LAYAR DAN PANEL SURYA

Kapal, 2015
Potensi energi alternatif yaitu angin dan matahari dapat dimanfaatkan secara maksimal untuk membantu energi kapal wisata di Madura. Desain lambung yang digunakan adalah tipe monohull dan katamaran pada displasemen yang sama sebesar 6 ton, didapatkan ...
Dedi Budi Purwanto, IKAP Utama
doaj   +1 more source

Elp1 facilitates RAD51-mediated homologous recombination repair via translational regulation

Journal of Biomedical Science, 2021
Background RAD51-dependent homologous recombination (HR) is one of the most important pathways for repairing DNA double-strand breaks (DSBs), and its regulation is crucial to maintain genome integrity.
Wei-Ting Chen, Huan-Yi Tseng, Chung-Lin Jiang, Chih-Ying Lee, Peter Chi, Liuh-Yow Chen, Kai-Yin Lo, I-Ching Wang, Fu-Jung Lin   +8 more
doaj   +1 more source

Enriched population of PNS neurons derived from human embryonic stem cells as a platform for studying peripheral neuropathies. [PDF]

PLoS ONE, 2010
BACKGROUND:The absence of a suitable cellular model is a major obstacle for the study of peripheral neuropathies. Human embryonic stem cells hold the potential to be differentiated into peripheral neurons which makes them a suitable candidate for this ...
Moran Valensi-Kurtz, Sharon Lefler, Malkiel A Cohen, Michal Aharonowiz, Rachel Cohen-Kupiec, Anton Sheinin, Uri Ashery, Benjamin Reubinoff, Miguel Weil   +8 more
doaj   +1 more source

IKAP is a cytoplasmic protein that interacts with α-tubulin and HDAC6.

, 2016
(A-D) Right panels: Representative western blots for IKAP, acetylated α-tubulin, and HDAC6. Left panels: Relative levels of acetylated α-tubulin in control (set to 1) and IKAP-deficient samples from (A) control and CKOTyrp2 FD DRG extracts, (B) control ...
Maya Donyo (234098), Yuvraj Joshi (3594623), Ziv Abramovitch (3594629), Tal Gradus (622920), Shiran Naftelberg (3594614), Eran Perlson (475929), Chen Farhy (203463), Sivan Yannai (3594626), Keren Ben-Yaakov (3594620), Ruth Ashery-Padan (389817), Shani Gluska (622918), Jonathan Zonszain (3594617), Gil Ast (10995)   +12 more
core   +1 more source

IKBKAP shRNAs reduce levels of IKAP protein and IKBKAP mRNA in ovo.

, 2013
(A) Schematic combines the known partial chicken IKBKAP sequence with the human IKBKAP sequence and indicates the regions of chicken IKBKAP to which shRNAs were designed and the regions used as the immunogens for generation of both antibodies (P1D8 and ...
Marta Chaverra (331391), Frances Lefcort (331394), Barbara J. Hunnicutt (331390), Lynn George (331393)   +3 more
core   +1 more source

Combined treatments with pridopidine elevates IKAP protein level more efficiently than either drug alone.

, 2019
Western blotting of FD cell lysates after indicated treatments. Proteins were extracted, and western blots were analyzed by using anti-IKAP antibody or HSC-70 antibody; the latter was used as a protein-loading control.
Maya Donyo (234098), Sivan Yannai (3594626), Jonathan Zonszain (3594617), Gil Ast (10995)   +3 more
core   +1 more source

Effect of continuous nursing care based on the IKAP theory on the quality of life of patients with chronic obstructive pulmonary disease

Medicine, 2020
Abstract Objective: To explore the effect of continuous nursing care based on the Information, Knowledge, Attitude, and Practice (IKAP) theory on the quality of life of patients with chronic obstructive pulmonary disease (COPD).
Li, Xin-Xia, Du, Xue-Wei, Song, Wen, Lu, Chang, Hao, Wen-Nv   +4 more
openaire   +2 more sources