IL-33 and IL-33-derived DC-based tumor immunotherapy [PDF]
Experimental and Molecular MedicineInterleukin-33 (IL-33), a member of the IL-1 family, is a cytokine released in response to tissue damage and is recognized as an alarmin. The multifaceted roles of IL-33 in tumor progression have sparked controversy within the scientific community ...
Myeong-Ho Kang, Yong-Soo Bae
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IL-33 and IL-3 synergistically induce CD25 expression on human basophils without functional IL-2 signaling: a potential marker of severe COVID-19 [PDF]
Frontiers in ImmunologyCD25 (IL-2 receptor alpha chain) is a key component of the high-affinity receptor for the IL-2 cytokine and regulates the proliferation, survival, and differentiation of immune cells.
Sruthi Vijaya Retnakumar +4 more
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Interleukin-33 (IL-33) promotes DNA damage-resistance in lung cancer [PDF]
Cell Death and DiseaseResistance to DNA damage is one of the primary mechanisms by which tumor cells evade the effects of standard chemotherapeutic agents and radiotherapy. Dynamic and complex interactions between the tumor microenvironment (TME) and tumor cells critically ...
Haoge Luo +7 more
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Sera Level and Polymorphism of Interleukin-33 Gene in Iraqi Females Patients with Breast Cancer
Ibn Al-Haitham Journal for Pure and Applied Sciences, 2021 Interleukin-33 [IL-33] is a specific ligand for the ST2 receptor, and a member of the IL-1 family. It is a dual-function protein that acts both as an extracellular alarmin cytokine, and an as an intracellular nuclear factor participates in maintaining ...
Asmaa M. Salih Almohaidi +3 more
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Interleukin-33 Primes Mast Cells for Activation by IgG Immune Complexes [PDF]
, 2012 Mast cells (MCs) are heterogeneous cells whose phenotype is modulated by signals received from the local microenvironment. Recent studies have identified the mesenchymal-derived cytokine IL-33 as a potent direct activator of MCs, as well as regulator of ...
Fishgal, Nadia +7 more
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Epithelial cell alarmin cytokines: Frontline mediators of the asthma inflammatory response
Frontiers in Immunology, 2022 The exposure of the airway epithelium to external stimuli such as allergens, microbes, and air pollution triggers the release of the alarmin cytokines IL-25, IL-33 and thymic stromal lymphopoietin (TSLP). IL-25, IL-33 and TSLP interact with their ligands,
Marc Duchesne, Isobel Okoye, Paige Lacy
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Clinical Hematology International, 2020 Patients undergoing allogeneic hematopoietic cell transplantation (HCT) are at risk for numerous acute and long-term complications from this procedure. Post-transplant diabetes mellitus (PTDM) is a common but under-recognized problem.
Uttam K. Rao, Brian G. Engelhardt
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Role of IL-33 in inflammation and disease [PDF]
, 2011 Interleukin (IL)-33 is a new member of the IL-1 superfamily of cytokines that is expressed by mainly stromal cells, such as epithelial and endothelial cells, and its expression is upregulated following pro-inflammatory stimulation.
Miller, Ashley M.
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An interleukin-33/ST2 signaling deficiency reduces overt pain-like behaviors in mice [PDF]
, 2013 Interleukin (IL)-33, the most recent member of the IL family of cytokines, signals through the ST2 receptor. IL-33/ST2 signaling mediates antigen challenge-induced mechanical hyperalgesia in the joints and cutaneous tissues of immunized mice. The present
Alves-Filho, J.C. +9 more
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MicroRNA29a regulates IL-33-mediated tissue remodelling in tendon disease [PDF]
, 2015 MicroRNA (miRNA) has the potential for cross-regulation and functional integration of discrete biological processes during complex physiological events.
Akbar, Moeed +9 more
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