Results 11 to 20 of about 1,096,946 (288)

Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer.

Cancer Cell, 2022
TH2 cells and innate lymphoid cells 2 (ILC2) can stimulate tumor growth by secreting pro-tumorigenic cytokines such as interleukin-4 (IL-4), IL-5, and IL-13.
A. Alam, Eric Levanduski, Parker J. Denz, Helena Solleiro Villavicencio, Maulasri Bhatta, Lamees Alhorebi, Yali Zhang, E. C. Gomez, B. Morreale, Sharon Senchanthisai, Jun Li, Steven G. Turowski, S. Sexton, S. Sait, P. Singh, Jianmin Wang, A. Maitra, P. Kalinski, R. DePinho, Huamin Wang, Wenting Liao, S. Abrams, B. Segal, Prasenjit Dey   +23 more
semanticscholar   +1 more source

Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction

Scientific Reports, 2023
Interleukin (IL)-33 is a broad-acting alarmin cytokine that can drive inflammatory responses following tissue damage or infection and is a promising target for treatment of inflammatory disease.
Elizabeth England, D. G. Rees, I. Scott, Sara Carmen, Denice T. Y. Chan, C. C. Chaillan Huntington, Kirsty F. Houslay, T. Erngren, M. Penney, Jayesh B. Majithiya, L. Rapley, Dorothy A. Sims, Claire Hollins, Elizabeth C. Hinchy, Martin D. Strain, B. Kemp, Dominic J. Corkill, Richard May, Katherine A. Vousden, Robin J. Butler, T. Mustelin, T. Vaughan, D. Lowe, C. Colley, E. S. Cohen   +24 more
semanticscholar   +1 more source

Role of IL-33-ST2 pathway in regulating inflammation: current evidence and future perspectives

Journal of Translational Medicine, 2023
Interleukin (IL)-33 is an alarmin of the IL-1 superfamily localized to the nucleus of expressing cells, such as endothelial cells, epithelial cells, and fibroblasts.
Yilu Zhou, Zhendong Xu, Zhiqiang Liu
semanticscholar   +1 more source

Interleukin-33 (IL-33): A critical review of its biology and the mechanisms involved in its release as a potent extracellular cytokine.

Cytokine, 2022
Interleukin-33 (IL-33), a member of the IL-1 family, is an alarmin cytokine with crucial roles in tissue homeostasis and repair, type 2 immunity, allergic and non-allergic inflammation, viral infection, and cancer.
C. Cayrol, J. Girard
semanticscholar   +1 more source

Macrophages originated IL-33/ST2 inhibits ferroptosis in endometriosis via the ATF3/SLC7A11 axis

Cell Death and Disease, 2023
Endometriosis is a gynecological inflammatory disease that is linked with immune cells, specifically macrophages. IL-33 secreted from macrophages is known to accelerate the progression of endometriosis.
Qiong Wu, Zongwen Liang, Jing Jiang, Xiaoming Feng, Jinming Liu, Zongfeng Zhang, Hongli Wang, Ning Wang, Yanling Gou, Zhi Li, Yingying Cao   +10 more
semanticscholar   +1 more source

Honokiol suppresses the aberrant interactions between renal resident macrophages and tubular epithelial cells in lupus nephritis through the NLRP3/IL-33/ST2 axis

Cell Death and Disease, 2023
Lupus nephritis (LN) is a type of immune-complex nephritis caused by systemic lupus erythematosus and is a major contributor to mortality and morbidity.
Qing Ma, Mengyang Xu, Xin Jing, Jiang Qiu, Shuo Huang, Honghao Yan, Lu Yin, Jiang Lou, Lisha Zhao, Yongsheng Fan, Ping Qiu   +10 more
semanticscholar   +1 more source

SUMOylated IL-33 in the nucleus stabilizes the transcription factor IRF1 in hepatocellular carcinoma cells to promote immune escape

Science Signaling, 2023
Interleukin-33 (IL-33) functions both as a secreted cytokine and as a nuclear factor, with pleiotropic roles in cancer and immunity. Here, we explored its role in hepatocellular carcinoma (HCC) and identified that a posttranslational modification altered
Zengbin Wang, B. Pan, Jiacheng Qiu, Xiaoxia Zhang, Xiaoling Ke, Shuling Shen, Xiaoxuan Wu, Yuxin Yao, N. Tang   +8 more
semanticscholar   +1 more source

Gasdermin D–mediated release of IL-33 from senescent hepatic stellate cells promotes obesity-associated hepatocellular carcinoma

Science immunology, 2022
Long-term senescent cells exhibit a secretome termed the senescence-associated secretory phenotype (SASP). Although the mechanisms of SASP factor induction have been intensively studied, the release mechanism and how SASP factors influence tumorigenesis ...
Ryota Yamagishi, Fumitaka Kamachi, Masaru Nakamura, S. Yamazaki, Tomonori Kamiya, M. Takasugi, Yi Cheng, Yoshiki Nonaka, Yoshimi Yukawa-Muto, L. Thuy, Yohsuke Harada, T. Arai, Tze Mun Loo, S. Yoshimoto, T. Ando, M. Nakajima, H. Taguchi, Takamasa Ishikawa, H. Akiba, S. Miyake, M. Kubo, Y. Iwakura, Shinji Fukuda, Wei‐Yu Chen, N. Kawada, A. Rudensky, S. Nakae, Eiji Hara, Naoko Ohtani   +28 more
semanticscholar   +1 more source

The Reparative Roles of IL-33

Transplantation, 2023
When discovered in the early 2000s, interleukin-33 (IL-33) was characterized as a potent driver of type 2 immunity and implicated in parasite clearance, as well as asthma, allergy, and lung fibrosis.
Johnny Bou Saba, H. Turnquist
semanticscholar   +1 more source

A dysregulated sebum–microbial metabolite–IL-33 axis initiates skin inflammation in atopic dermatitis

Journal of Experimental Medicine, 2022
This study demonstrates that a dysregulated sebum–microbial metabolite–IL-33 axis is involved in the pathogenesis of atopic dermatitis, possibly by playing an initiating role in the induction of skin inflammation.
Z. Qiu, Zhenlai Zhu, Xiaochun Liu, Baichao Chen, H. Yin, Chaoying Gu, Xiaokai Fang, Ronghui Zhu, Tianze Yu, Wenli Mi, Hong Zhou, Yufeng Zhou, X. Yao, Wei Li   +13 more
semanticscholar   +1 more source