Results 41 to 50 of about 1,096,946 (288)

Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s. [PDF]

, 2016
Group 2 innate lymphoid cells (ILC2s) and type 2 helper T cells (Th2 cells) are the primary source of interleukin 5 (IL-5) and IL-13 during type 2 (allergic) inflammation in the lung.
Austen, K Frank, Barrett, Nora A, Kanaoka, Yoshihide, Locksley, Richard M, O'Leary, Claire E, von Moltke, Jakob   +5 more
core   +1 more source

Maternal IL-33 critically regulates tissue remodeling and type 2 immune responses in the uterus during early pregnancy in mice

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance Recent clinical studies suggest that abnormal interleukin-33 (IL-33) signaling is associated with poor pregnancy outcomes in women, including recurrent pregnancy loss, preeclampsia, and preterm labor.
Nuriban Valero-Pacheco, Eric K Tang, Noura Massri, Rachel Loia, Anat Chemerinski, Tracy Wu, S. Begum, Darine W El-Naccache, W. Gause, R. Arora, N. Douglas, Aimee M Beaulieu   +11 more
semanticscholar   +1 more source

In vitro Culture with Cytokines Provides a Tool to Assess the Effector Functions of ILC2s in Peripheral Blood in Asthma

Journal of Asthma and Allergy, 2021
Li Y Drake,1,2 Kathleen R Bartemes,1,3 Kay A Bachman,1 John B Hagan,1 Hirohito Kita1,4 1Division of Allergic Diseases and Department of Medicine, Mayo Clinic, Rochester, MN, USA; 2Department of Anesthesiology and Perioperative Medicine, Mayo Clinic ...
Drake LY, Bartemes KR, Bachman KA, Hagan JB, Kita H   +4 more
doaj  

IL-33 induces thymic involution-associated naive T cell aging and impairs host control of severe infection

Nature Communications, 2022
Severe infection commonly results in immunosuppression, which leads to impaired pathogen clearance or increased secondary infection in both humans and animals. However, the exact mechanisms remain poorly understood.
Lei Xu, C. Wei, Ying Chen, Yue Wu, Xiaoli Shou, Wenjie Chen, D. Lu, Haoran Sun, Wei Li, B. Yu, Xiaowei Wang, Xiaojun Zhang, Yanxiong Yu, Zhigang Lei, R. Tang, Ji-feng Zhu, Yalin Li, Linrong Lu, Hong Zhou, Sha Zhou, C. Su, Xiaojun Chen   +21 more
semanticscholar   +1 more source

IL-33 in Mental Disorders

Medicina, 2021
Mental disorders are common in the general population; every year about 25% of the total European population is affected by a mental condition. The prevalence of psychiatric disorders might be underestimated.
Gianluca Pandolfo, Giovanni Genovese, Marco Casciaro, Maria Rosaria Anna Muscatello, Antonio Bruno, Giovanni Pioggia, Sebastiano Gangemi   +6 more
doaj   +1 more source

Interleukin-33 predicts poor prognosis and promotes ovarian cancer cell growth and metastasis through regulating ERK and JNK signaling pathways [PDF]

, 2015
Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer, it remains a huge challenge to understand the cellular and molecular mechanisms of the aggressive behavior of EOC cells.
Armstrong, Baekkevold, Barbour, Bell, Bergis, Besnard, Chao Gao, Chen, Choi, Fang, Gao, Gao, Goff, Gonzalez-Campora, Heintz, Hu, Hu, Hui-Rong Jiang, Ishikawa, Jemal, Jiang, Jingli Zheng, Jovanovic, Jovanovic, Kezuo Hou, Kurian, Kurowska-Stolarska, Lavoue, Liew, Liu, Lohning, Lu, Mark Barbour, Marquez, McGuire, Miller, Milovanovic, Moritz, Oshikawa, Pei, Rong Mu, Schmieder, Schmitz, Shuang Cao, Solinas, Stirling, Sun, Xiaoguang Tong, Xu, Yang Zhao, Zeyda, Zhou   +51 more
core   +1 more source

A novel function of NLRP3 independent of inflammasome as a key transcription factor of IL-33 in epithelial cells of atopic dermatitis

Cell Death and Disease, 2021
Atopic dermatitis (AD) is a common chronic pruritic inflammatory skin disorder characterized by recurrent eczematous lesions. Interleukin (IL)−33, a cytokine of the IL-1 family, was found to play an important role in the pathogenesis of AD.
Jie Zheng, Lu Yao, Yijing Zhou, Xiaoqun Gu, Can Wang, Kaifan Bao, Yang Sun, Min Hong   +7 more
semanticscholar   +1 more source

Endogenous IL-33 and Its Autoamplification of IL-33/ST2 Pathway Play an Important Role in Asthma. [PDF]

, 2020
IL-33 and its receptor ST2 are contributing factors to airway inflammation and asthma exacerbation. The IL-33/ST2 signaling pathway is involved in both the onset and the acute exacerbations of asthma.
Dumouchel, Justin P, Li, Jinghong, Li, Willis X, Magat, Jenna M, Murray, Fiona, Thomas, Joanna L   +5 more
core  

Wounds that heal and wounds that don't - The role of the IL-33/ST2 pathway in tissue repair and tumorigenesis [PDF]

, 2016
IL-33 is a member of the IL-1 family of cytokines. IL-33 is predominantly located within the nucleus of cells where it plays a role in gene regulation.
Brint, Elizabeth K., McInnes, Iain B., Millar, Neal L., O'Donnell, Charlotte   +3 more
core   +1 more source

Effects of IL-33 on HaCAT cell line and psoriasis-like lesion in mouse model [PDF]

Jichu yixue yu linchuang, 2020
Objective To investigate the effects of interleukin-33(IL-33)on HaCAT cells and psoriasis-like inflammation induced by imiquimod(IMQ) in mice. Methods Twenty-four hours after HaCAT cells were plated, the cell proliferation and autophagy-related protein ...
DUAN Ya-ju, WANG Wen-qian, HU Hua, FU Dan-dan, SONG Xiang-feng, TIAN Zhong-wei
doaj